General practitioner‑offered low‑dose CT screening for lung cancer

Involvement of General Practitioners in Lung Cancer Screening

This trial tests whether offering yearly low‑dose CT screening through your general practitioner will increase screening participation among high‑risk smokers aged 50–74.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 500 (estimated)
• Ages: 50 Years to 74 Years
• Sex: All
• Sponsor: Assistance Publique - Hôpitaux de Paris (other)
• Locations: 1 site (Paris)
• Trial ID: NCT06956040 on ClinicalTrials.gov

What this trial studies

The study asks GPs to propose low‑dose chest CT screening to patients at high risk for lung cancer and then measures whether those patients complete the initial scan and a repeat scan one year later. Eligible participants are 50–74 years old, current smokers or those who quit within 15 years with at least a 20 pack‑year history, able to attend scans at participating Paris hospitals, and without recent CT or active serious comorbidity. The primary outcome is adherence to the screening pathway defined by initial and one‑year follow‑up scans; secondary data include reasons for nonparticipation and safety signals. The trial is conducted under the Assistance Publique–Hôpitaux de Paris network at Hôpital Cochin and Hôpital Bichat.

Who should consider this trial

Good fit: Adults 50–74 who are current smokers or quit within the last 15 years with ≥20 pack‑years, covered by French social security, able to travel independently to the participating Paris hospitals, and without recent thoracic CT or active severe comorbidity.

Not a fit: People with prior lung cancer, recent thoracic CT, severe comorbidities or poor functional status, symptomatic or obviously progressive disease, or inability to travel to the study sites are unlikely to benefit from this screening pathway.

Why it matters

Potential benefit: If successful, more high‑risk individuals could complete regular low‑dose CT screening, leading to more cancers being found at an earlier, potentially curable stage.

How similar studies have performed: Large randomized trials like NLST and MILD have shown that low‑dose CT screening reduces lung cancer mortality, but using general practitioners to propose and deliver screening is a more recent implementation approach that has been less extensively tested.

Eligibility criteria

Inclusion Criteria :

* Adults aged 50-74
* Active smoker or weaned smoker for less than 15 years, of at least 20 pack-years
* Affiliation with a social security scheme or CMU (beneficiary or beneficiary entitled)
* Written informed consent prior to study participation

Exclusion Criteria :

* History of lung cancer
* Thoracic CT scan performed within the previous year
* 1-year follow-up not possible
* Inability to travel independently to Hôpital Cochin or Hôpital Bichat for scans
* People with severe co-morbidities contraindicating exploration and/or management of lung cancers
* People in poor general health (=PS2 and above)
* People with a history of cancer under active surveillance by thoracic computed tomography (CT and PET scans)
* People with rest dyspnea (=mMRC4)
* Recent weight loss, altered general condition or hemoptysis, raising suspicion of progressive lung cancer
* Signs of respiratory infection (fever, productive cough)
* Patients under guardianship, curatorship or protected adults
* Inability to give free written informed consent prior to study participation

Where this trial is running

Paris

• Hôpital Cochin — Paris, France (RECRUITING)

Study contacts

• Principal investigator: Céline BUFFEL du VAURE, PhD — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Céline BUFFEL du VAURE, PhD

Conditions: Lung Cancer, Screening, Lung cancer, General practitioners, CT Scan