Improving lung function during chest physiotherapy for patients on mechanical ventilation
Evaluation of Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients
This study is testing if a special breathing technique can help improve lung function in patients on mechanical ventilation by comparing two different ways of supporting their breathing.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Créteil) |
| Trial ID | NCT06805357 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of respiratory physiotherapy techniques, specifically Rib Cage Compressions (RCC), in mechanically ventilated patients. It aims to compare the pulmonary recruitment achieved during physiotherapy sessions conducted under two different ventilatory modes: Volume Assist Control Ventilation (V-ACV) and Pressure Support Ventilation (PSV). The primary outcome is the change in end-expiratory lung volume (ΔEELV) measured before and after the physiotherapy sessions. Secondary outcomes include assessments of respiratory mechanics, gas exchange, and patient tolerance. The study employs advanced measurement tools to evaluate the impact of these techniques on lung function.
Who should consider this trial
Good fit: Ideal candidates are patients under invasive mechanical ventilation who require frequent tracheal aspirations due to high secretion levels.
Not a fit: Patients with recent surgeries, significant respiratory or hemodynamic instability, or those under 18 years old may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance lung recruitment and improve respiratory function in critically ill patients undergoing mechanical ventilation.
How similar studies have performed: While the specific comparison of ventilatory modes during respiratory physiotherapy is novel, similar studies have shown positive outcomes with respiratory physiotherapy techniques in mechanically ventilated patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient under assisted ventilation (in V-ACV or PSV) triggering all ventilator cycles * Patient deemed " secretive ": requiring ≥ 2 tracheal aspirations every 3 hours * Patient (or relative) who has given consent to participate in the research * Patient covered by social security Exclusion Criteria: * Age under 18 years * Legal guardian required * Recent cardiac and/or thoracic and/or abdominal surgery (\< 3 months) * Rib fracture(s) * Pneumothorax and/or presence of a chest drain * Recent neurosurgery (\< 3 months) and/or proven or suspected increased intracranial pressure (ICP) * Hemodynamic instability defined as: noradrenaline ≥ 1mg/h, adrenaline ≥ 0.5 mg/h, dobutamine ≥ 5γ/kg/min. * Respiratory instability defined as: PEEP \> 10 cmH2O and/or PaO2/FiO2 \< 150 mm Hg * Pregnancy * Hemoptysis * Sever skin lesions (e.g., burns, Lyell's syndrome) * Patient under foreign health insurance
Where this trial is running
Créteil
- Intensive Care Medicine Department Henri Mondor Hospital — Créteil, France (Recruiting)
Study contacts
- Study coordinator: Guillaume Pr CARTEAUX, MD,PhD
- Email: guillaume.carteaux@aphp.fr
- Phone: 01 45 17 86 38
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.