Condition

Osteoarthritis clinical trials and research

• 64Clinical trials
• 291NIH research projects
• 1New in 30 days
• 25Countries

Newest Osteoarthritis clinical trials

All recruiting trials (64)

• Autologous adipose-derived stem cell injections for knee osteoarthritis

  We’re testing whether injecting a patient’s own fat-derived stem cells into the knee can help people with knee OA feel less pain and move better, compared with a standard hyaluronic acid treatment.

  Recruiting at 3 sites Yonsei University · Incheon and 2 other locations · NCT07901790

• Early wear of a Vitamin E-infused liner in a dual-mobility hip replacement

  This study tests whether a Vitamin E-infused liner in a dual-mobility hip implant wears as little as a conventional liner over two years in adults needing hip replacement.

  Recruiting Phase 4 Uppsala University · Uppsala, Uppsala County · NCT07863557

• Preoperative Music to Ease Anxiety Before Hip or Knee Replacement

  Patients awaiting hip or knee replacement listen to their own music through noise‑canceling headphones to see if it lowers preoperative anxiety.

  Recruiting Columbia University · New York, New York · NCT07845695

• Weight-bearing dangling exercises vs VMOb NMES for knee osteoarthritis

  This study tests whether weighted dangling exercises or VMOb muscle NMES help people with knee osteoarthritis.

  Recruiting University of Lahore · Lahore, Punjab Province · NCT07701174

• Post-op prednisone vs standard steroid regimen after knee or hip replacement

  This study tests a 5-day oral prednisone course after knee or hip replacement to see if pain, swelling, and glucose control are better or different than the usual intraoperative steroid approach.

  Recruiting Phase 4 Columbia University · New York, New York · NCT07630896

• AI-based prediction of five major diseases using integrated health data

  Researchers are testing an AI model to see if they can predict the onset of five major diseases in adults 30–65 by combining medical records with biospecimens and lifestyle data.

  Recruiting Asan Medical Center · Seoul, Seoul Special City · NCT07595718

• Personalized total knee replacement: computer navigation versus robotic-arm assistance

  We test whether robotic-arm assistance or computer navigation during personalized total knee replacement gives adults with knee osteoarthritis a more natural-feeling knee and better function.

  Recruiting Groupe Hospitalier Diaconesses Croix Saint-Simon · Paris, Paris · NCT07574762

• Can robotic-assisted knee replacement with functional alignment improve outcomes vs. standard knee replacement?

  This trial tests whether using the VELYS robotic system during total knee replacement helps patients with knee osteoarthritis feel better and move more comfortably compared with conventional non-robotic surgery.

  Recruiting Golden Jubilee National Hospital · Glasgow, Scotland · NCT07551856

• Genicular Artery Embolization for Knee Osteoarthritis

  This study tests whether Genicular Artery Embolization can relieve knee pain in adults with mild-to-moderate knee osteoarthritis who have tried standard treatments.

  Recruiting Northwestern University · Chicago, Illinois · NCT07537153

• Arthrosamid versus steroid injections for managing knee osteoarthritis.

  This trial will test whether a single Arthrosamid hydrogel injection works better than a standard steroid plus local anesthetic injection for adults with symptomatic knee osteoarthritis.

  Recruiting Phase 4 Cappagh National Orthopaedic Hospital · Dublin, Dublin · NCT07489521

• Synovial Tissue as a Biomarker to Guide Early Osteoarthritis Care

  This study tests whether examining synovial tissue early in osteoarthritis can reveal biomarker pathotypes that relate to how the disease presents and progresses.

  Recruiting at 2 sites Nantes University Hospital · Nantes and 1 other locations · NCT07473414

• Eloralintide for knee osteoarthritis pain in adults with overweight or obesity

  This trial tests whether eloralintide reduces knee osteoarthritis pain in adults who are overweight or have obesity.

  Recruiting at 132 sites Phase 3 Eli Lilly and Company · Mobile, Alabama and 146 other locations · NCT07353931

• Herbal combination (Boswellia, turmeric, grape extract) for hip or knee osteoarthritis

  This study will test whether a daily herbal supplement containing Boswellia serrata, turmeric (curcumin), and grape extract (Vitis vinifera) reduces pain and improves function in adults with hip or knee osteoarthritis.

  Recruiting Middlesex University · London · NCT07324746

• Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy for Older Adults with Knee Osteoarthritis

  This trial will test whether applying high-intensity pulsed electromagnetic fields to both the knee and quadriceps reduces pain and improves function more than applying it only to the knee in adults 60 and older with knee osteoarthritis.

  Recruiting Hospital Civil de Guadalajara · Guadalajara, Jalisco · NCT07198750

• Integrated healthy lifestyle and pain care for people with musculoskeletal conditions in rural areas

  Aiming to see if an in-person or a virtual, lifestyle-focused pain care program helps rural adults with musculoskeletal pain and lifestyle risks feel less impact from their pain.

  Recruiting at 2 sites University of Sydney · Coffs Harbour, New South Wales and 2 other locations · NCT07173335

• Follow-up of the Incompass Total Ankle System after total ankle replacement surgery.

  The Incompass Total Ankle System will be followed to see if it is safe and helps reduce pain and improve quality of life in adults having total ankle replacement.

  Recruiting at 5 sites Stryker Trauma and Extremities · Morton Grove, Illinois and 4 other locations · NCT07118501

• Choose to Move Replacement Ready for people waiting for hip or knee replacement

  This project will test whether the Choose to Move Replacement Ready program helps older adults on hip or knee replacement waitlists increase physical activity, improve mobility, and support psychosocial health.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07069179

• Antigravity treadmill rehabilitation after hip or knee replacement

  This project will test whether antigravity or body-weight-supported treadmill training helps people aged 60–75 recover walking, balance, and confidence after hip or knee replacement.

  Recruiting Wroclaw University of Health and Sport Sciences · Trzebnica, Lower Silesian Voivodeship · NCT07040878

• Trans-arterial embolization to treat lumbar facet joint pain

  This single-site effort will try trans-arterial embolization with Embozene microparticles to see if it reduces lumbar facet (facetogenic) pain in adults with osteoarthritis who have not improved with standard treatments.

  Recruiting Northwell Health · Manhasset, New York · NCT06965452

• Beat Pain Better

  This project tests two ways of using text messages to invite adults 45+ with osteoarthritis to physical activity counseling and two formats of the Walk with Ease walking program to help them start and stick with self-management.

  Recruiting at 2 sites Phase 3 University of Utah · Salt Lake City, Utah and 2 other locations · NCT06932887

• Two Botox injections plus custom rigid splinting for painful base-of-thumb osteoarthritis

  This trial tests whether two ultrasound-guided Botox injections together with a custom rigid splint reduce thumb-base pain in adults with base-of-thumb osteoarthritis.

  Recruiting Phase 2/3 Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06902805

• Comparing retro-walking and forward-walking on an underwater treadmill for knee osteoarthritis

  This study is testing whether walking backwards or forwards on an underwater treadmill helps people with knee osteoarthritis feel less pain and move better.

  Recruiting Cairo University · Cairo, Cairo Governorate and 1 other locations · NCT06896032

• Examining the effects of different exercise levels on arthritis symptoms

  This study tests how different amounts of exercise can help people with arthritis feel better over six months.

  Recruiting University of South Carolina · Columbia, South Carolina · NCT06880653

• Registry for hip and knee joint implants and revisions

  This study collects information from patients who have had hip or knee joint replacements to see how well the implants work over time and to improve future surgeries.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT06850818

• Cultural adaptation and validation of a pain questionnaire in Turkish

  This study is testing a new version of a pain questionnaire for Turkish-speaking people with chronic pain conditions like osteoarthritis, back pain, and fibromyalgia to see if it accurately reflects their experiences.

  Recruiting Hacettepe University · Ankara, Altındağ · NCT06825650

• Acupuncture treatment for knee osteoarthritis

  This study is testing if acupuncture can help relieve knee pain and improve movement in people with knee osteoarthritis.

  Recruiting Jiangxi University of Traditional Chinese Medicine · Nanchang, Jiangxi · NCT06805188

• Comparing two knee replacement techniques for better outcomes

  This study is testing two different knee replacement techniques to see which one helps people with knee osteoarthritis feel better and move more easily after surgery.

  Recruiting Phase 4 McMaster University · Hamilton, Ontario · NCT06787417

• Helping seniors with osteoarthritis use their SilverSneakers fitness benefits

  We will test whether a brief outreach with mailed materials and two phone calls helps older adults with osteoarthritis start using their SilverSneakers benefits, improve physical and social well-being, and reduce related healthcare use.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06782347

• Impact of ultra-processed foods on rheumatic diseases

  This study looks at how eating ultra-processed foods might affect people with chronic rheumatic diseases like rheumatoid arthritis and osteoarthritis to see if it makes their symptoms worse.

  Recruiting Hospices Civils de Lyon · Lyon · NCT06776965

• Injection of amniotic suspension allograft for knee osteoarthritis treatment

  This study is testing if injections of amniotic suspension allograft can help people with knee osteoarthritis feel less pain and move better compared to other treatments.

  Recruiting at 2 sites Phase 3 Chang Gung Memorial Hospital · Kaohsiung, Taiwan and 1 other locations · NCT06704893

• Registry to monitor outcomes after total joint surgery

  This study is trying to see how total joint surgery for arthritis affects patients' comfort and ability to move, while also gathering information for future research.

  Recruiting Spokane Joint Replacement Center · Spokane, Washington · NCT06687109

• Comparing augmented reality guidance to traditional methods in knee replacement surgery

  This study is testing if using a new augmented reality system during knee replacement surgery helps patients with osteoarthritis have better results than traditional methods.

  Recruiting Foundation for Orthopaedic Research and Education · Tampa, Florida · NCT06663384

• Corticosteroid plus hyaluronic acid hip injection combined with physiotherapy for mild hip conditions.

  This will test whether a combined corticosteroid and hyaluronic acid hip injection plus physiotherapy helps people aged 40–60 with mild hip osteoarthritis, labral tears, or femoroacetabular impingement reduce pain and move better.

  Recruiting ArthroBiologix Inc. · Hamilton, Ontario · NCT06653985

• EMPHASYS cup placement with VELYS non-invasive hip navigation in total hip replacement

  This research tests whether using the VELYS non-invasive hip navigation system helps surgeons place the EMPHASYS acetabular cup more accurately during total hip replacement for people with osteoarthritis or other hip conditions.

  Recruiting at 2 sites DePuy Orthopaedics · Gainesville, Florida and 1 other locations · NCT06631638

• Mobile program to reduce pain and improve health in older adults with osteoarthritis

  This trial tests a mobile group-based program combining frequent movement and dietary changes to help older adults with obesity and knee or hip osteoarthritis lose weight, move more, and reduce pain.

  Recruiting Phase 2 Wake Forest University · Winston-Salem, North Carolina · NCT06623669

• Evaluating Lipiodol Embolization for Hand Osteoarthritis Pain Relief

  This study is testing whether a procedure using Lipiodol can help relieve pain and improve hand function in people with osteoarthritis who haven't found relief from standard treatments.

  Recruiting Phase 1/2 University Hospital, Grenoble · Échirolles · NCT06611007

• Using glucocorticoids to relieve acute osteoarthritis pain in the emergency department

  This study is testing if adding glucocorticoids to regular pain medications can help adults with sudden osteoarthritis pain feel better in the emergency department.

  Recruiting Phase 4 WellSpan Health · York, Pennsylvania · NCT06603662

• Culturally tailored pain management for Black elders

  This study is testing a new pain management program designed specifically for Black elders with chronic pain to see if it helps them feel better and manage their pain more effectively.

  Recruiting University of Florida · Gainesville, Florida · NCT06512727

• Evaluating OA-SYS for knee osteoarthritis treatment

  This study is testing a new treatment called OA-SYS using adult stem cells to see if it can help people with moderate to severe knee osteoarthritis feel better and improve their knee function.

  Recruiting Phase 2 Ageless Biotech, Inc. · Las Vegas, Nevada · NCT06485843

• Assessing knee osteoarthritis in patients with tibial plateau fractures in Norrbotten

  This study looks at how common knee osteoarthritis is in people from Norrbotten, Sweden who had tibial plateau fractures, and it also checks how different factors might affect their recovery.

  Recruiting Umeå University · Luleå, Norrbotten County · NCT06451510

• Using light therapy to help recovery after knee surgery

  This study tests if using near-infrared light therapy can help people over 20 recover better from knee surgery by reducing pain, swelling, and inflammation.

  Recruiting National Taiwan University Hospital Hsin-Chu Branch · Hsinchu · NCT06426251

• Comparing pain relief from two medications after knee surgery

  This study tests whether mirogabalin or pregabalin works better to relieve pain after knee surgery for people aged 50-85 with osteoarthritis.

  Recruiting Thammasat University Hospital · Khlong Luang, Changwat Pathum Thani · NCT06328062

• Understanding migraines and neuropathic pain in osteoarthritis patients

  This study looks at how often people with osteoarthritis experience migraines and nerve pain to better understand the connection between these conditions.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, France · NCT06224959

• Analyzing cell therapies for osteoarthritis using donated tissues

  This study is testing whether cells from donated tissues of patients with polydactyly and hip dislocation can help create new cartilage for people with osteoarthritis.

  Recruiting Keele University · Oswestry, Shropshrie · NCT06167928

• Using Nexsphere-F to treat knee osteoarthritis pain

  This study is testing a new treatment called Nexsphere-F to see if it can help relieve knee pain in people aged 50 and older who haven’t found relief from other treatments.

  Recruiting Next Biomedical Co., Ltd. · Seoul, Seodaemun-gu · NCT05917028

• Comparing SPECT-CT and MRI for diagnosing foot and ankle osteoarthritis

  This study is testing whether SPECT-CT or MRI is better at diagnosing osteoarthritis in the foot and ankle for patients who have symptoms.

  Recruiting Martini Hospital Groningen · Groningen · NCT05912153

• Using low-dose radiation to treat osteoarthritis

  This study is testing if low-dose radiation therapy can help people with osteoarthritis feel less pain compared to a placebo treatment.

  Recruiting University of Erlangen-Nürnberg Medical School · Erlangen, Bavaria · NCT05887284

• Identifying factors that regulate bone health

  This study is trying to find out what factors affect bone health by looking at bone samples from patients having orthopedic surgeries to help improve treatments for conditions like osteoporosis and osteoarthritis.

  Recruiting at 4 sites Relation Therapeutics · London, Greater London and 7 other locations · NCT05732870

• Observational study on total wrist replacement outcomes with KinematX implant

  This study is testing how well the KinematX wrist replacement helps people regain movement and strength in their wrist after surgery.

  Recruiting at 4 sites Extremity Medical · Loma Linda, California and 3 other locations · NCT05719935

• Thromboxane A2 and Osteoarthritis

  Researchers are testing whether thromboxane A2 affects cartilage cells and osteoarthritis in humans and animals to see if it could help explain cartilage health and point toward new therapies.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT05593640

• Comparing two types of stem cell injections for knee and hip osteoarthritis

  This study is testing whether a stem cell injection from fat works better than one from bone marrow to help people with knee and hip osteoarthritis feel less pain and move better.

  Recruiting Phase 2 Dr. G. Karmy Medicine Professional Corporation · Brampton, Ontario · NCT05507099

• Evaluating ketorolac for treating upper extremity joint and tendon pain

  This study is testing whether ketorolac or triamcinolone injections can help people with joint and tendon pain in their shoulders, elbows, wrists, and hands feel better and improve their function.

  Recruiting at 4 sites Phase 4 Emory University · Atlanta, Georgia and 3 other locations · NCT05292339

• Using ultrasound to relieve osteoarthritis pain

  This study tests whether a continuous ultrasound treatment can help people with mild to moderate osteoarthritis feel less pain and move better compared to a topical pain relief gel.

  Recruiting Phase 1 ZetrOZ, Inc. · Tampa, Florida · NCT05254574

• Umbilical-cord mesenchymal stem cell infusion and joint injection for osteoarthritis

  This treatment will try giving cultured umbilical‑cord mesenchymal stem cells by intravenous infusion and directly into the affected joint to see if they are safe and help people with osteoarthritis.

  Recruiting at 2 sites Phase 1 The Foundation for Orthopaedics and Regenerative Medicine · Naples, Florida and 1 other locations · NCT05147675

• Accelerated MRI techniques for assessing cartilage health

  This study is testing new, faster MRI methods to see if they can help people at risk for osteoarthritis by checking the health of their cartilage more accurately.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04536103

• Using patients' own cells to treat osteoarthritis

  This study is testing whether using patients' own stem cells and platelet-rich plasma can help treat osteoarthritis better than traditional methods.

  Recruiting Healeon Medical Inc · Valencia, California and 1 other locations · NCT04238143

• Improving nutrition for patients undergoing joint replacement surgery

  This study tests if giving extra nutrition to patients who are malnourished before joint replacement surgery can help them recover better and improve their overall health.

  Recruiting at 2 sites NYU Langone Health · New York, New York and 1 other locations · NCT04210284

• Combining PRP with fat and bone marrow for treating osteoarthritis

  This study is testing whether combining platelet-rich plasma with fat or bone marrow can help people with osteoarthritis feel better in their major joints.

  Recruiting Phase 2 Pagdin Health · Kelowna, British Columbia · NCT03984461

• Low-impact exercise program for joint pain relief

  This study is testing if joining low-impact exercise classes can help people with knee, hip, and ankle pain from osteoarthritis feel better and move easier.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT03711773

• Using patients' own cells to treat hip osteoarthritis pain and inflammation

  This study is testing whether using patients' own cells in injections can help reduce pain and inflammation in people with hip osteoarthritis.

  Recruiting Phase 2 VivaTech International, Inc. · Grove City, Pennsylvania · NCT02844764

• Using autologous cell therapy to treat knee osteoarthritis pain and inflammation

  This study is testing if a new cell therapy using your own body’s cells can help relieve pain and swelling in people with knee osteoarthritis.

  Recruiting Phase 2 VivaTech International, Inc. · Grove City, Pennsylvania · NCT02844751

• Using autologous cell therapy to treat shoulder osteoarthritis pain and inflammation

  This study is testing whether injections of a special type of cell therapy can help people with shoulder osteoarthritis feel less pain and inflammation.

  Recruiting Phase 2 VivaTech International, Inc. · Grove City, Pennsylvania · NCT02844738

• Observing outcomes after knee ligament reconstruction

  This study looks at people who had knee ligament surgery to see how well they're doing and if they experience re-injuries or arthritis over the next 20 years.

  Recruiting Fonds de Dotation pour la Recherche Clinique en Orthopédie et Pathologie du Sport · Paris · NCT02511158

• Collection of data on orthopaedic conditions and rehabilitation

  This study collects information from patients with bone and muscle conditions at the University of Florida to help improve understanding and treatment of these issues.

  Recruiting University of Florida · Gainesville, Florida · NCT00411060

NIH-funded research (newest 40 of 291)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis

  This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11644470

• Identifying OA subtypes and early warning signs before joint damage

  This grant asks researchers to find early, invisible clues of osteoarthritis subtypes so we can target treatments before joints are damaged.

  NIH research Hebrew Rehabilitation Center for Aged · Boston, United States · NIH-11629811

• Digital biomarkers to guide personalized rehab after ACL injury

  Aims to use wearable sensors and phone videos to predict early osteoarthritis risk after ACL surgery so rehabilitation can be tailored to each patient.

  NIH research Carnegie-Mellon University · Pittsburgh, United States · NIH-11611050

• Aberrant mechano-oxygen coupling linked to zinc-rich mineralization in osteoarthritis

  Aims to understand how abnormal joint forces affect cartilage and bone, causing zinc-rich mineral deposits and harmful blood vessel growth in osteoarthritis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11538110

• Notch signaling in TMJ osteoarthritis: uncovering mechanisms and new targets

  Researchers are studying how Notch signaling affects TMJ osteoarthritis to identify new ways to protect and repair the jaw joint.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11522770

• Nanoparticles delivering an sPLA2 blocker for knee osteoarthritis

  This project uses tiny, drug-filled nanoparticles to deliver an sPLA2-blocking medicine into the knee to reduce inflammation and slow knee osteoarthritis in people with painful knee OA.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11516244

• Remote tai chi for knee OA in everyday care

  A nationwide study will test remotely delivered tai chi for people with knee osteoarthritis to see if it helps pain and function when added to usual care.

  NIH research Tufts Medical Center · Boston, United States · NIH-11506893

• Biomarkers that predict osteoarthritis risk in people at higher risk

  A long-term study will look for protein markers in body fluids that could predict who will develop knee osteoarthritis before symptoms appear.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11461903

• What makes CPPD and osteoarthritis worsen in older adults and how colchicine might help

  Researchers will study how inflammation and biomarkers relate to knee pain in adults with CPPD and osteoarthritis to see if daily colchicine helps.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11459691

• Sensory nerves and joint cells talk to each other in knee arthritis

  This grant tests how nerve signals and joint cells interact in knee osteoarthritis, with a focus on CGRP pathways and how they affect pain and joint damage.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11453379

• Acid-sensing GPR68 helps protect joints in osteoarthritis

  This project looks at a specific brain-freeway: an acid-sensing receptor called GPR68, to see if activating it can reduce joint inflammation and slow osteoarthritis in adults.

  NIH research Emory University · Atlanta, United States · NIH-11450120

• Noninvasive cartilage imaging to predict early osteoarthritis

  A noninvasive MRI method called dualMRI will be tested to see if it can predict early joint degeneration before pain or scans show OA.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11447928

• Deep phenotyping to map osteoarthritis progression

  A study will combine symptoms, joint structure, and daily activity data to identify patterns that predict osteoarthritis progression and potential biomarkers.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11445771

• Role of a human SIRT5 variant in osteoarthritis development

  A study to understand how a rare SIRT5 gene change may make osteoarthritis more likely or worse.

  NIH research Ohio University Athens · Athens, United States · NIH-11445292

• From knee to brain: a whole-body look at inflammation in knee osteoarthritis

  Aims to map inflammation across the body and brain in people with knee osteoarthritis using advanced imaging to help explain and improve pain and treatment.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11429205

• Understanding hip osteoarthritis risk from hip shapes and genetics

  Researchers will look at how the shape of the hip and genetics influence the chances of developing hip OA and needing joint replacement, using AI to study large patient data.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11424533

• Microvascular health in osteoarthritis: how blood vessels affect joints

  This grant asks to explore how tiny blood vessels in the joint contribute to osteoarthritis and whether targeting them could shift disease outcomes to help patients.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11421477

• Genetics of Osteoarthritis and Recovery After Joint Replacement

  A study looking at how genes affect osteoarthritis and recovery after hip or knee replacement to help tailor rehabilitation for veterans.

  NIH research Birmingham VA Medical Center · Birmingham, United States · NIH-11418232

• Determinants of rapid knee osteoarthritis progression using radiograph features

  A patient-friendly look at how knees with osteoarthritis may progress more quickly, using advanced X-ray measurements to identify who is at higher risk.

  NIH research University of Arizona · Tucson, United States · NIH-11416360

• Targeted, temperature-responsive delivery to prevent post-traumatic osteoarthritis after knee injuries

  A new approach uses heat-sensitive, collagen-based carriers to slowly release medicines in injured knee joints to reduce the risk of osteoarthritis after an ACL injury.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11415530

• New ways to study nerve cells linked to knee osteoarthritis pain

  A researcher at a major university is exploring new models to understand how dorsal root ganglion nerves drive knee OA pain, with the aim of finding better ways to relieve pain.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11414947

• Telehealth Mindful Exercise for Knee Osteoarthritis (TEMPO)

  A 10-week, at-home telehealth program blends mindfulness with exercise to help adults with knee osteoarthritis manage pain and improve function.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11412932

• Dual-action nanoparticle therapy for osteoarthritis

  A patient-friendly look at a new treatment approach that combines two tiny drug-delivery systems to protect and repair damaged knee tissue in people with osteoarthritis.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11405011

• Risk factors for shoulder osteoarthritis in adults

  This project looks at why some people develop painful shoulder osteoarthritis, especially as they age, and how factors like work, sex, and genetics influence the need for shoulder replacement.

  NIH research Washington University · Saint Louis, United States · NIH-11402777

• Digital biomarkers to guide personalized rehab after ACL injury

  A new study at Carnegie Mellon will use wearable sensors and phone videos to find early signals that predict cartilage changes after ACL surgery, with the goal of guiding tailored rehabilitation.

  NIH research Carnegie-Mellon University · Pittsburgh, United States · NIH-11402731

• Genetics of Osteoarthritis: What Makes Some People More Susceptible and How It Progresses

  This NIH grant aims to understand why some people develop osteoarthritis, why it affects people differently, and how it progresses over time.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11401396

• How ankle fusion changes the subtalar joint in people with varus ankle arthritis

  This study looks at how ankle fusion surgery affects the subtalar joint in people with varus-type ankle arthritis and aims to improve long-term joint health.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11400479

• Understanding how early protein breakdown affects knee injuries and PTOA

  Researchers will study how enzymes that cut proteins contribute to early osteoarthritis after ACL injuries, with the goal of finding early warning signals and targets for treatment.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11399981

• Identifying knee osteoarthritis risk genes through genetics and cartilage biology

  Researchers are studying knee OA to find the genetic factors and how they affect cartilage, with the goal of guiding future treatments.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11399912

• Tissue Adhesive RNA Interference Nanoparticles to Block OA Progression

  A new treatment approach uses special RNA interference nanoparticles injected into joints to slow or stop osteoarthritis growth after injuries or aging, aiming to reduce pain and delay joint replacement for patients with PTOA/OA.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11392867

• Home-based Leg Dexterity Training for knee osteoarthritis

  A portable, wireless device helps adults with ACL injury or knee osteoarthritis practice quick, instability-based leg movements at home to ease pain and improve function.

  NIH research Neuromuscular Dynamics, LLC · La Crescenta, UNITED STATES · NIH-11390950

• Daily and Localized NSAID Patch for Knee Osteoarthritis Pain

  A new patch uses gentle ultrasound to push a common pain-relieving NSAID into the knee to help people with osteoarthritis feel less pain.

  NIH research Zetroz Systems, LLC · Trumbull, United States · NIH-11390466

• Role of CCR2 in osteoarthritis affecting joints and muscles

  This grant tests how the CCR2 pathway and its partner CCL2 influence joint damage, pain, and muscle changes after joint injuries like ACL tears.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11389599

• How visit length and content affect knee osteoarthritis care

  This grant studies how longer visits and more thorough, personalized conversations between patients and clinicians can improve outcomes for adults with knee osteoarthritis.

  NIH research University of California at Davis · Davis, United States · NIH-11385278

• Carrier-free siRNA Drugs to Slow Osteoarthritis

  A new kind of gene-silencing medicine designed to slow bone- and joint-destroying arthritis by targeting the body’s own genes, without using carrier particles.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11384825

• Move and Snooze: add sleep help to an exercise plan to ease knee pain in older adults

  A program combines a personalized exercise plan with a digital sleep-improvement course to reduce knee pain for adults aged 65 and up who have osteoarthritis.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11384493

• WNT signals in hip cartilage and osteoarthritis

  A study from the University of Rochester is examining how a cellular signaling pathway called WNT, and a mechanosensor in cartilage cells, influence Hip OA progression and how this could lead to new therapies.

  NIH research University of Rochester · Rochester, United States · NIH-11382101

• Metabolomic biomarker profiles for osteoarthritis

  A research project at Montana State University looks for metabolite patterns in blood and joint fluid that could signal early osteoarthritis before symptoms become severe.

  NIH research Montana State University - Bozeman · Bozeman, United States · NIH-11381970

• Gut health and multi-joint osteoarthritis in people and dogs

  A scientist team will study whether a leaky gut contributes to pain and worsening of osteoarthritis in people who have OA in multiple joints, using both people and pet dogs for insights.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11381217

• NFAT1 transcription factor as a therapy for osteoarthritis

  Aimed at using a gene regulator (NFAT1) to slow or reverse osteoarthritis in adults by delivering therapy with AAV vectors.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11381118

Related topics

Quick answers

How many Osteoarthritis clinical trials are recruiting right now?

64, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (28 trials), France (8 trials), Canada (6 trials), United Kingdom (5 trials), South Korea (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 4: 6, Phase 3: 3, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →