Notch signaling in TMJ osteoarthritis: uncovering mechanisms and new targets
Official title: Molecular Mechanism by which Notch Signaling regulates TMJ Osteoarthritis
Funded at Medical University of South Carolina · NIH-11522770 · Data updated 2026-11-12
Researchers are studying how Notch signaling affects TMJ osteoarthritis to identify new ways to protect and repair the jaw joint.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $413,825 |
| NIH project number | 7R01DE034088-02 |
| Project ID | NIH-11522770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with TMJ osteoarthritis or early joint degeneration who could participate in future translational research or clinical trials targeting Notch-related pathways.
✕Less likely to help
People without TMJ disorders or without relevance to Notch-related targets may not benefit from this research.
What this research studies
The project looks at how Notch signaling influences cartilage breakdown and regeneration in the jaw joint, with a focus on TMJ osteoarthritis. Using preclinical TMJ degeneration models, the team aims to map cell behavior and signaling pathways that drive degeneration and potential healing. The goal is to pinpoint targets, like Jagged 1/2, that could be leveraged to prevent damage and promote repair in people with TMJ-OA. Findings could pave the way for new therapies to preserve jaw function and reduce pain.
Why it matters
Potential benefit: If successful, this work could lead to targets and strategies to slow or reverse TMJ osteoarthritis and improve jaw function and quality of life.
How similar studies have gone: Prior studies have shown that manipulating Notch and BMP signaling can influence cartilage biology in animal models, suggesting potential for therapy development.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Yadav, Sumit — Medical University of South Carolina
- Study coordinator: Yadav, Sumit
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.