Role of a human SIRT5 variant in osteoarthritis development
Official title: Determining the role of a novel human OA-associated SIRT5 allele in osteoarthritis development
Funded at Ohio University Athens · NIH-11445292 · Data updated 2026-11-12
A study to understand how a rare SIRT5 gene change may make osteoarthritis more likely or worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio University Athens NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | August 15, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $665,615 |
| NIH project number | 1R01AR086771-01A1 |
| Project ID | NIH-11445292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with or at risk for osteoarthritis, especially those with the SIRT5 F101L mutation or related genetic susceptibility.
✕Less likely to help
People without the SIRT5 mutation or without OA-related risk may not benefit from this specific genetic focus.
What this research studies
This project will explore how a specific human SIRT5 mutation (F101L) affects joint cells and metabolism, possibly contributing to osteoarthritis. Researchers will use cartilage cells from humans and animal models to examine metabolic balance, inflammation, and how the mutation changes SIRT5 activity. The goal is to identify how this genetic change increases OA risk and to uncover potential targets for future therapies. If successful, the work could explain part of why OA develops with aging and pave the way for personalized approaches for people with this mutation.
Why it matters
Potential benefit: Understanding this genetic risk could lead to targeted therapies that slow or prevent OA in people carrying the SIRT5 mutation.
How similar studies have gone: Prior work shows SIRT5 influences cartilage biology and OA risk, supporting potential benefits from this line of research.
Where this research is happening
-
Ohio University Athens
Athens, United States Active
Researchers
- Principal investigator: Zhu, Shouan — Ohio University Athens
- Study coordinator: Zhu, Shouan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.