Accelerated MRI techniques for assessing cartilage health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on developing novel, fast, and reproducible MRI techniques to assess early changes in cartilage health, particularly for patients at risk for osteoarthritis. It aims to standardize and validate MR T1ρ and T2 relaxation time imaging methods across multiple vendors and sites, addressing challenges such as long acquisition times and variability in quantification. By creating dedicated calibration phantoms and standardized protocols, the study seeks to facilitate the integration of these advanced imaging techniques into clinical practice and future multi-site trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Group 1

1\. Age \> 18

Group 2

1\. Age 18-50

Group 3

1. Age 18-50
2. Sustain an acute full ACL tear in one knee; the contralateral knee uninjured
3. Undergo ACL reconstructions and standard rehabilitation

Group 4

1\. Age 18-50

Exclusion Criteria:

Group 1

1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
2. Pregnancy.

Group 2

1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
2. Pregnancy.
3. History of osteoarthritis and inflammatory arthritis
4. Previous injury and/or surgery on either knee

Group 3

1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
2. Pregnancy.
3. Inability to undergo standard pre- and post-injury/operative rehabilitation

Group 4

1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
2. Pregnancy.
3. History of osteoarthritis and inflammatory arthritis
4. Previous injury and/or surgery on either knee

Where it's running

• Cleveland Clinic Foundation
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Xiaojuan Li — Director, Program for Advanced Musculoskeletal Imaging
• Study coordinator: Xiaojuan Li, PhD
• Email: lix6@ccf.org
• Phone: 510-685-3495

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.