Thromboxane A2 and Osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how thromboxane A2 (TXA2) influences chondrocyte differentiation and cartilage homeostasis. It includes in vitro experiments, a rat OA model to relate TXA2 levels with disease progression, and a small human cohort to examine associations between TXA2 in blood and synovial fluid with OA features. The study compares TXA2 effects to prostacyclin, another arachidonic acid metabolite, on thermogenic markers and cartilage biology. Results could inform nutritional or pharmacological approaches to OA and related metabolic conditions. The research is led by CHU de Nice with collaboration from the French Society of Rheumatology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* presence of knee osteoarthritis with effusion, , no inflammatory disease

Exclusion Criteria:

* anticoagulant treatment
* inflammatory disease

Where it's running

• CHU de NICE
  Nice, France Recruiting

Study contacts

• Study coordinator: Christian ROUX, MD, PhD
• Email: roux.c2@chu-nice.fr
• Phone: +33492035491

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.