Condition

Musculoskeletal Pain clinical trials and research

• 32Clinical trials
• 34NIH research projects
• 12Countries

Newest Musculoskeletal Pain clinical trials

All recruiting trials (32)

• Physical activity and musculoskeletal pain among lawyers

  Agroup of lawyers will be categorized by how physically active they are to see if activity levels relate to how often and where they have musculoskeletal pain and how this connects to stress and job satisfaction.

  Recruiting Suleyman Demirel University · Isparta · NCT07827937

• Three rTMS approaches to lessen insomnia-related pain after exercise-induced muscle soreness

  This study tests whether three different rTMS approaches can reduce pain sensitivity and improve recovery in adults with insomnia after inducing muscle soreness from exercise.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07827677

• Insomnia and Sleep Disruption's Effect on Pain Sensitivity and Muscle Soreness After Exercise

  This study tests whether poor sleep or insomnia affects how people feel pain and recover from exercise-induced muscle soreness in healthy adults.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07827664

• Acute Muscle Pain and Sleep in Insomnia vs. Healthy Sleepers

  This study tests how temporary muscle soreness after intense exercise affects sleep in people with insomnia compared to healthy adults.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07826650

• Light color therapy to help chronic pain

  This small crossover study tests whether colored light (S-cone chromatic light) can reduce pain in adults with fibromyalgia or chronic widespread pain compared with white light over two 7-day periods.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07825792

• Ischemic Compression Plus Home Exercise for Non-Specific Neck Pain

  This study tests whether adding ischemic compression to a home exercise program helps reduce neck pain and disability more than home exercise alone in adults with non-specific neck pain.

  Recruiting Istanbul Rumeli University · Istanbul, Bakırköy · NCT07685418

• GERD patients: see how symptoms relate to posture, pain, and activity

  This study will look at whether people with GERD have different posture, pain levels, and activity compared with what their GERD symptoms suggest.

  Recruiting Karabuk University · Karabük, Karabük Province · NCT07643779

• Understanding subtypes of chronic musculoskeletal pain in youth

  This observational study tests whether distinct brain and immune profiles can explain chronic musculoskeletal pain in teens and young adults to guide more precise treatments.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07602595

• Video program to help older adults manage chronic pain

  A short video program called Reclaim Your Day tests whether six 30-minute stories and lessons can help older adults with chronic musculoskeletal pain use ACT-based strategies to reduce pain interference and improve mood and quality of life.

  Recruiting Butler Hospital · Providence, Rhode Island · NCT07404618

• Relationship between high PainDETECT scores, pain location, and diagnosis in musculoskeletal care

  See if PainDETECT questionnaire scores relate to pain locations and clinical diagnoses in adults with musculoskeletal pain who visit a sports medicine clinic.

  Recruiting Uskudar University · Istanbul · NCT07356115

• Colored-light pain relief and brain mapping in chronic musculoskeletal pain

  This trial will test whether showing different colored lights to the eyes can reduce pain and change brain activity in adults with chronic musculoskeletal pain compared with healthy, age- and sex-matched controls.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT07245303

• A practical program using emotional awareness and expression therapy for Veterans with chronic musculoskeletal pain

  This project will try emotional awareness and expression therapy (EAET) versus cognitive behavioral therapy to see if it helps Veterans with moderate-to-severe musculoskeletal chronic pain feel less pain and have fewer mental-health symptoms.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07218757

• Lifestyle medicine program for older adults with chronic musculoskeletal pain

  This program will test whether four face-to-face health coaching sessions about lifestyle changes can reduce pain and improve quality of life for older adults with chronic musculoskeletal pain.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT07194239

• Integrated healthy lifestyle and pain care for people with musculoskeletal conditions in rural areas

  Aiming to see if an in-person or a virtual, lifestyle-focused pain care program helps rural adults with musculoskeletal pain and lifestyle risks feel less impact from their pain.

  Recruiting at 2 sites University of Sydney · Coffs Harbour, New South Wales and 2 other locations · NCT07173335

• Promoting Pain Self-Management for chronic musculoskeletal pain in the military

  This study tests two holistic, non-drug pain care approaches to see if they help adults with chronic musculoskeletal pain within the Military Health System.

  Recruiting at 2 sites Brooke Army Medical Center · Fairbanks, Alaska and 4 other locations · NCT06940986

• Evaluating intranasal fentanyl for pain management in pediatric emergencies

  This study is testing if using intranasal fentanyl can effectively manage pain in children who come to the emergency room for musculoskeletal injuries.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT06832046

• Eastern Principles Therapy for Injury Prevention in Nurses

  This study is testing if a new therapy based on Eastern mindfulness can help nurses and nursing aides in the U.S. and Thailand prevent work-related injuries and reduce stress better than traditional therapy or no treatment at all.

  Recruiting Bowling Green State University · Bowling Green, Ohio · NCT06813495

• Reformer pilates exercises for chronic musculoskeletal pain relief

  This study tests whether reformer pilates exercises can help people with chronic musculoskeletal pain feel better and improve their overall well-being.

  Recruiting Atılım University · Ankara, Select State · NCT06706037

• Online yoga versus Acceptance and Commitment Therapy for chronic musculoskeletal pain in veterans

  This project will test whether online yoga works as well as Acceptance and Commitment Therapy to reduce chronic musculoskeletal pain in veterans.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT06704061

• Group visits combined with chiropractic care for older adults with chronic spine pain

  This trial will test whether combining chiropractic treatments with group medical visits helps adults 65 and older who have chronic neck, thoracic, or low back pain.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06632535

• Low-load resistance training with blood flow restriction for military personnel with lower limb injuries

  This study is testing if a special type of exercise using low weights and blood flow restriction can help military personnel with lower limb injuries feel less pain and recover better.

  Recruiting Defence Medical Rehabilitation Centre, UK · Loughborough, Leicestershire · NCT06621914

• Culturally tailored pain management for Black elders

  This study is testing a new pain management program designed specifically for Black elders with chronic pain to see if it helps them feel better and manage their pain more effectively.

  Recruiting University of Florida · Gainesville, Florida · NCT06512727

• Helping Black patients manage chronic pain and depression

  This study is testing a new coaching program to help Black patients with chronic pain and depression stick to non-drug treatments and feel better.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06500780

• Evaluating stress management's impact on musculoskeletal health in employees

  This study is testing if a six-week stress management program can help employees feel better physically and reduce time off work due to muscle and joint pain caused by stress.

  Recruiting at 2 sites University of Thessaly · Larissa, Biopolis- Larissa and 1 other locations · NCT06488547

• Virtual-reality self-hypnosis for HIV-related chronic pain

  This trial will try a virtual-reality self-hypnosis program to see if it reduces chronic pain in adults living with HIV.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06398847

• Pain education program for chronic musculoskeletal pain

  This study tests if a new pain education program can help adults with long-lasting musculoskeletal pain manage their pain better and improve their quality of life.

  Recruiting at 3 sites Aalborg University · Holbæk, Region Sjælland and 2 other locations · NCT06297447

• Using a mobile app to track pain in musculoskeletal disease patients

  This study tests whether using a mobile app to track pain and daily activities can help people with musculoskeletal diseases understand their symptoms better.

  Recruiting at 2 sites Ente Ospedaliero Cantonale, Bellinzona · Bologna and 1 other locations · NCT06283199

• Mind-body and walking program for older adults with chronic pain

  This study tests if a 10-week mind-body and walking program can help older adults with chronic pain feel better compared to their usual treatment.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06119698

• Understanding how the brain processes chronic pain in children

  This study is trying to understand how children's brains handle chronic pain from conditions like migraines and fibromyalgia to see what helps them recover.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT05814497

• Understanding pain processing in adolescents with chronic pain conditions

  This study looks at how teenagers with ongoing pain conditions feel and process pain differently than those with specific pain or healthy teens to better understand what might cause their pain.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT05752396

• Using Chinese herbs to help breast cancer patients with pain from treatment

  This study is testing whether Chinese herbs can help postmenopausal women with hormone-receptor positive breast cancer feel less pain from their treatment.

  Recruiting Universiti Tunku Abdul Rahman · Bukit Bintang, Kuala Lumpur · NCT04843865

• Neck and low back pain among medical students at UWI Mona

  This project will test whether a standardised spine exercise program helps medical students at UWI Mona who have neck or low back pain while also measuring how common these pains are and students' spine-health knowledge.

  Recruiting The University of The West Indies · Kingston, Kingston and 1 other locations · NCT03707288

NIH-funded research (34)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• mHealth tool to boost physical therapy outcomes for adults with musculoskeletal pain

  A mobile health app is being tested to help adults in physical therapy stay on track with home exercises and improve pain and function.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11607117

• Biopsychosocial factors in pediatric chronic musculoskeletal pain

  A study at Cincinnati Children’s Hospital will look at how biological, psychological, and social factors contribute to chronic muscle and joint pain in young people to find better ways to help them.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11419876

• Nonaddictive pain-relief prodrug gel for joint and musculoskeletal pain

  A new, nonaddictive pain-relief gel uses a hydromorphone prodrug that stays at the site of pain to reduce pain without strong addiction risk.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11401234

• Neurobiological and psychosocial factors that may turn acute teen pain into chronic pain

  A study following teenagers with acute musculoskeletal pain to understand why some develop chronic pain and how biology and psychology interact to shape their outcomes.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11395328

• Tech-guided walking plus Tai Chi to improve function for veterans with COPD and chronic pain

  This program helps veterans with COPD and long-term muscle or joint pain use a web-based step program together with Tai Chi to move more and feel stronger.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11381365

• Resilience Coaching for Teens with Long-Lasting Muscle and Bone Pain

  This project offers resilience coaching to help teenagers manage ongoing muscle and bone pain and improve their well-being.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11363175

• GET SMART: Tailored graded exposure for kids with chronic musculoskeletal pain

  A multi-site trial tests a stepwise, personalized exposure-based therapy for children with long-standing musculoskeletal pain and their families.

  NIH research Stanford University · Stanford, United States · NIH-11363104

• Online yoga vs. acceptance-based therapy for chronic musculoskeletal pain in veterans

  A large, well-designed study will compare online yoga to acceptance and commitment therapy to help veterans manage chronic musculoskeletal pain.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11309136

• Biopsychosocial Intergenerational Factors in Pediatric Amplified Musculoskeletal Pain

  A study in children with amplified musculoskeletal pain and their mothers aims to understand how stress, psychology, and family factors influence the development and persistence of the pain.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11293093

• Understanding muscle pain caused by breast cancer treatments

  This study is looking at why some post-menopausal women with hormone receptor positive breast cancer experience painful side effects from their hormone treatments, and it hopes to find ways to help doctors choose the best treatment for each patient right from the start, making their experience easier and more comfortab

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11212285

• Why teens' muscle and joint pain can become long-term

  This project looks at brain changes and social-emotional factors in teens with recent muscle or joint pain to find who is likely to develop long-lasting pain.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11159569

• Mobile app to support home exercises during physical therapy for muscle or joint pain

  This project uses a phone app to help people in physical therapy for muscle or joint pain follow their home exercise program and track their progress.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11143817

• Nonaddictive hydromorphone hydrogel for muscle and joint pain

  A long-lasting, non-addictive gel medicine that releases pain relief right at sore muscles and joints without reaching the brain.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11136478

• A Digital Program for Young People with Chronic Muscle and Joint Pain

  This project is creating a new online program to help young people and their parents manage ongoing muscle and joint pain.

  NIH research Stanford University · Stanford, United States · NIH-11120991

• Helping adolescents with chronic pain build resilience

  This study is looking at a program called PRISM that helps teenagers with ongoing pain by teaching them skills to handle stress and build resilience, so they can feel better both physically and emotionally while connecting with others who understand what they're going through.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11098675

• How sleep affects pain in teens after surgery

  This study is looking at how sleep and other factors affect pain in teens after surgery, with the hope of finding ways to help them avoid long-lasting pain.

  NIH research Stanford University · Stanford, United States · NIH-11061410

• Understanding different types of musculoskeletal pain

  This study, led by Dr. Adam Goode at Duke University, is looking at different types of musculoskeletal pain, like low back pain and knee osteoarthritis, to understand how acute pain can turn into chronic pain, with the goal of finding better treatments for people who suffer from these conditions.

  NIH research Duke University · Durham, United States · NIH-11061206

• Exploring the effects of medical marijuana on chronic pain in older adults

  This study is looking at how medical marijuana can help older adults with ongoing pain in their muscles and joints, and it wants to find out which people might get the most relief from it by looking at their health and personal backgrounds over three months.

  NIH research University of Florida · Gainesville, United States · NIH-11056415

• Understanding how sex differences affect chronic pain after trauma

  This study is looking at how men and women feel and deal with long-lasting pain after an injury, focusing on tiny molecules in the body that might affect this pain differently for each sex, with the hope of finding better treatments for everyone.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11042705

• Comparing online yoga and therapy for chronic pain relief

  This study is looking at whether online yoga can help reduce chronic pain just as well as a type of therapy called Acceptance and Commitment Therapy (ACT), especially for veterans who might not have easy access to regular healthcare.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11040817

• Improving physical activity and mental health in older veterans with pain and depression

  This study is looking at how a special program called MOTIVATE can help older veterans who are dealing with pain and depression by encouraging them to be more active and set personal goals, all with the support of a health coach over 12 weeks, to help them feel better and enjoy life more.

  NIH research VA North Texas Health Care System · Dallas, United States · NIH-11006245

• How stressful life events affect chronic pain through changes in DNA

  This study is looking at how stressful life events might lead to long-lasting pain in muscles and joints, especially by examining changes in a specific gene, and it's designed for people who have gone through trauma to help them understand how their experiences could affect their pain.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10998952

• Combining physical therapy with mindfulness for chronic pain patients on opioids

  This study is looking at how combining mindfulness practices with physical therapy can help people with chronic pain who are using long-term opioids, making it easier for them to manage their pain and reduce their reliance on medication in a friendly and supportive setting.

  NIH research University of Utah · Salt Lake City, United States · NIH-10989921

• Using a mobile app to improve physical therapy outcomes for musculoskeletal pain

  This study is looking at how a mobile app can help people with musculoskeletal pain get more out of their physical therapy by making it easier for them to follow their exercise routines and stay connected with their therapists.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10952496

• Understanding how resilience and physical activity affect chronic pain in adolescents

  This study is looking at how being mentally strong and active can help teenagers with ongoing pain in their muscles and joints, and it involves 60 teens sharing their experiences and wearing devices to track their activity levels.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-10909983

• Understanding and managing musculoskeletal pain

  This study is looking into how we can better understand and manage pain from musculoskeletal and rheumatic diseases, with the goal of finding safer and more effective treatments that can help patients feel better.

  NIH research Rush University Medical Center · Chicago, United States · NIH-10892120

• Understanding why some adolescents develop chronic pain from acute musculoskeletal issues

  This study is looking at why some teenagers with short-term pain end up with long-lasting pain, and it aims to find ways to help prevent that from happening by understanding both their brain activity and emotional well-being.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10888368

• A new nonaddictive pain relief method for musculoskeletal disorders

  This study is testing a new way to relieve pain for people with muscle and joint issues by using a special gel that releases a safe, non-addictive medication right where it hurts, helping to manage pain without the risks of traditional opioids.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-10881885

• Developing a digital treatment for young people with chronic pain

  This study is testing a new online program called iGET Living to help teenagers with ongoing pain in their muscles and joints by encouraging them to gradually get back to activities they might have been avoiding, and it’s designed to be easy for both the teens and their parents to use.

  NIH research Stanford University · Stanford, United States · NIH-10874721

• New injectable system for managing musculoskeletal pain

  This study is testing a new way to deliver pain relief for people with conditions like osteoarthritis and lower back pain, using a special injection that combines numbing medicine with small amounts of anti-inflammatory drugs to help manage pain safely and without the risks of opioids.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-10852320

• Understanding how social rejection affects pain stigma in teens with chronic pain

  This study is looking at how feeling rejected or judged because of pain affects teenagers with chronic pain, and it aims to create a helpful tool to better understand and support them in their recovery.

  NIH research Connecticut Children's Medical Center · Hartford, United States · NIH-10781892

• New injectable system for managing musculoskeletal pain

  This study is testing a new way to deliver long-lasting pain relief for people with conditions like osteoarthritis and lower back pain, using a special injection that combines local anesthetics with small amounts of anti-inflammatory medicine to help manage pain safely without opioids.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-10657572

• Preventing chronic pain in older adults after acute musculoskeletal injuries

  This study is all about helping older adults who have sudden pain from injuries, like falls, by teaching them how to make better choices about their treatment, so they can avoid long-lasting pain and feel more in control of their recovery.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10539315

• Understanding why some young people develop chronic musculoskeletal pain

  This study is looking at why some young people aged 12 to 20 develop long-lasting pain after having short-term pain, and it aims to find out how things like emotions and behaviors play a role, so we can help those who might be at risk.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10455657

Related topics

Quick answers

How many Musculoskeletal Pain clinical trials are recruiting right now?

32, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (15 trials), Turkey (Türkiye) (5 trials), Hong Kong (4 trials), Greece (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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