Clinical trial Recruiting at 4 sites Phase 4 Interventional Ages 18 and up

Evaluating ketorolac for treating upper extremity joint and tendon pain

Official title: Single Blind RCT to Evaluate the Effect of Ketorolac in Upper Extremity Tendinopathy and Arthropathy

Run by Emory University · NCT05292339 · Data updated 2026-11-12

This study is testing whether ketorolac or triamcinolone injections can help people with joint and tendon pain in their shoulders, elbows, wrists, and hands feel better and improve their function.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment160 (estimated)
SponsorEmory University
Academic / other
Locations4 sites (Atlanta, Georgia and 3 other locations)
StatusRecruiting
StartedJanuary 31, 2023
Main results expectedJuly 2027
Study endsJuly 2027
Registry record updatedSeptember 3, 2026
Trial IDNCT05292339 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older with symptomatic upper extremity tendinopathy or arthropathy who have not had prior surgical treatment.

Probably not a fit

Patients under 18, those who have had recent injections, or those with active infections or contraindications to the medications will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the effectiveness of ketorolac and triamcinolone injections for patients suffering from tendinopathy and arthropathy in the shoulder, elbow, wrist, and hand. Participants will receive either injection type and will be monitored over a 24-week period to evaluate pain relief and functional improvement. The study employs a blinded approach to ensure unbiased results regarding the efficacy of these treatments. It addresses a gap in existing research concerning the management of smaller joint conditions compared to larger joints.

Why it matters

Potential benefit: If successful, this study could provide a new effective treatment option for patients with upper extremity pain due to tendinopathy and arthropathy.

How similar studies have gone: While there is existing research on corticosteroid injections for larger joints, studies specifically evaluating ketorolac for smaller joint conditions are limited, making this approach relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 or older,
* symptomatic tendinopathy or arthropathy of the shoulder, elbow, hand, or wrist who have not undergone prior surgical treatment for their condition.
* Diagnoses may include trigger finger, De Quervain's tenosynovitis, radiocarpal osteoarthritis, first carpometacarpal (CMC) joint osteoarthritis, metacarpophalangeal joint osteoarthritis, or proximal interphalangeal joint osteoarthritis.

Exclusion Criteria:

* Patients under the age of 18,
* Patients who have undergone prior triamcinolone or ketorolac injections within the past 6 months,
* Patients who have undergone prior surgical treatment for their hand condition,
* Patients with allergy or contraindication to triamcinolone or ketorolac injection,
* Patients with an active infection at the treatment site \[active infection defined as cellulitis, purulence, fever, chills, or presence of elevated inflammatory markers, ie. white blood cells (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)\].

Where it's running

  • Emory Saint Joseph's Hospital
    Atlanta, Georgia, United States
    Recruiting
  • Emory University Orthopaedic and Spine Center
    Atlanta, Georgia, United States
    Recruiting
  • 12 Executive Park Drive
    Atlanta, Georgia, United States
    Recruiting
  • Emory University Orthopaedic and Spine Hospital
    Atlanta, Georgia, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.