Synovial Tissue as a Biomarker to Guide Early Osteoarthritis Care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study aims to categorize early osteoarthritis by analyzing synovial tissue obtained during biopsy. Researchers will identify histological pathotypes in synovial samples and explore how these patterns relate to clinical features and early disease phenotypes. The protocol focuses on patients with early OA who are already being considered for knee intra-articular injection and may guide future personalized management. The study uses synovial biopsies to advance understanding of synovitis and its role in disease progression. No results are reported here; the goal is to describe the early synovial pathology and its clinical associations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of early osteoarthritis defined by the following clinical criteria:

  1. score ≤ 85% in at least two of the four categories of the KOOS questionnaire: pain, symptoms/signs, function and quality of life;
  2. presence of tenderness on palpation of the joint space or crepitus (clinical examination);
  3. Kellgren and Lawrence (KL) score of 0 or 3 (X-rays).
* Referred for therapeutic management including an intra-articular injection in the affected knee
* Patient affiliated with a social security scheme
* Patient able to understand the protocol and having signed an informed consent form.

Exclusion Criteria:

* Minors
* Adults under guardianship or trusteeship
* Pregnant women
* Breastfeeding women
* Protected patients
* Curative anticoagulation
* Thrombocytopenia \< 50,000 platelets/mm3
* Patients who object to participating in the study.

Where it's running

• CHU de Nantes
  Nantes, France Recruiting
• CHU de Nantes
  Nantes, France Recruiting

Study contacts

• Study coordinator: Benoit Le Goff, Pr
• Email: benoit.legoff@chu-nantes.fr
• Phone: 02 40 08 48 25

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.