Comparing SPECT-CT and MRI for diagnosing foot and ankle osteoarthritis
SPECT-CT Versus MRI for the Diagnosis of Symptomatic Osteoarthritis in the Ankle, Hind- and Midfoot.
This study is testing whether SPECT-CT or MRI is better at diagnosing osteoarthritis in the foot and ankle for patients who have symptoms.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 132 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Martini Hospital Groningen Academic / other |
| Locations | 1 site (Groningen) |
| Trial ID | NCT05912153 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the diagnostic performance of SPECT-CT and MRI in patients with symptomatic osteoarthritis of the ankle, hindfoot, and midfoot. It involves a prospective cohort design where patients aged 18 and older, referred to the Martini Hospital Groningen, will undergo both imaging techniques as part of their standard workup. The study will assess parameters such as sensitivity, specificity, and predictive values to determine which imaging modality provides better diagnostic accuracy. The findings could help standardize diagnostic protocols for osteoarthritis in these areas.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with suspected symptomatic osteoarthritis of the ankle, hindfoot, or midfoot and a pain score of 4 or higher.
Not a fit: Patients with contraindications for SPECT-CT or MRI, recent trauma, or isolated forefoot pathology may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy for osteoarthritis in the foot and ankle, potentially enhancing treatment plans for patients.
How similar studies have performed: While there have been studies indicating the potential of SPECT-CT in diagnosing osteoarthritis, this study is among the first to prospectively compare SPECT-CT and MRI in this specific context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Suspected symptomatic ankle, hind- or midfoot OA * Informed consent * Age ≥ 18 years * Average NRS ≥4 over the past week. Exclusion Criteria: * Contraindication for surgery * Contraindication for SPECT-CT or MRI * Contraindication for intra-articular injections * Isolated forefoot pathology * Fracture, ligamentous or tendon injury of the ankle, hind- and/or midfoot trauma within one year before presentation * History of neurological disease * History of foot and/or ankle surgery (affected side) * Inability to read and understand the written information
Where this trial is running
Groningen
- Martini Hospital — Groningen, Netherlands (Recruiting)
Study contacts
- Principal investigator: Tom van Raaij, MD/PhD — Martini Ziekenhuis
- Study coordinator: Arthur van Hasselt, MD
- Email: a.vanHasselt@mzh.nl
- Phone: 0031646345384
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.