Condition

Osteoarthritis, Knee clinical trials and research

• 66Clinical trials
• 4New in 30 days
• 24Countries

Newest Osteoarthritis, Knee clinical trials

All recruiting trials (66)

• SVF cellular mix, secretome, and knee response in osteoarthritis

  This study tests the cellular composition and secretome of research-only adipose-derived SVF in adults with knee OA who are already planned to receive an autologous SVF injection as part of their care.

  Recruiting Yonsei University · Seoul · NCT07898501

• Effect of a Resistance Exercise Program on IGF-1 Levels in Knee Osteoarthritis

  A structured 8-week resistance exercise program is being tested to see if it changes blood IGF-1 levels and improves knee OA symptoms in adults with knee OA and metabolic traits.

  Recruiting Sisli Hamidiye Etfal Training and Research Hospital · Istanbul, Istanbul · NCT07890155

• 2-mm subchondral drilling vs sequential 4-mm and 2-mm drilling during CARTISTEM implantation for knee cartilage defects

  This study tests whether drilling the knee with a 2-mm drill alone works as well as sequential 4-mm then 2-mm drilling when combined with CARTISTEM treatment for medial knee cartilage defects.

  Recruiting Yonsei University · Seoul · NCT07881445

• Undenatured Type II Collagen for Knee Osteoarthritis Pain (Three-Arm Trial)

  This study tests whether taking undenatured type II collagen capsules once daily for 4 months can reduce knee pain in adults with knee osteoarthritis, compared with two collagen formulations and a placebo.

  Recruiting Universidad Católica San Antonio de Murcia · Murcia, Murcia · NCT07870967

• Serum Fetuin‑A and COMP levels in knee osteoarthritis

  This study tests whether levels of Fetuin‑A and COMP in the blood relate to how severe knee osteoarthritis is in patients compared with healthy volunteers.

  Recruiting Antalya Training and Research Hospital · Antalya · NCT07706569

• Pain relief for knee osteoarthritis: a 2nd phase study of LY4065967 vs placebo

  Researchers are testing whether LY4065967 can help reduce knee pain from osteoarthritis in adults, compared with placebo.

  Recruiting at 36 sites Phase 2 Eli Lilly and Company · Birmingham, Alabama and 35 other locations · NCT07641517

• Cryotherapy to Cut Opioid Use After Knee Replacement

  This trial tests whether compressive cryotherapy with a Game Ready device can lower opioid use and improve recovery after total knee replacement in adults 60–80.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires · NCT07630337

• Using smartphone video to measure knee movement in osteoarthritis

  This project will test whether a smartphone video system called OpenCap can measure knee movement and mechanics in people with early knee osteoarthritis and how those measurements compare with lab motion capture, symptoms, and knee imaging.

  Recruiting VA Office of Research and Development · Palo Alto, California · NCT07580222

• Can robotic-assisted knee replacement with functional alignment improve outcomes vs. standard knee replacement?

  This trial tests whether using the VELYS robotic system during total knee replacement helps patients with knee osteoarthritis feel better and move more comfortably compared with conventional non-robotic surgery.

  Recruiting Golden Jubilee National Hospital · Glasgow, Scotland · NCT07551856

• Good Boost+ for adults awaiting knee replacement

  This feasibility trial tests whether a community-based prehabilitation program called Good Boost+ can be run with people waiting for a knee replacement and whether it could work in larger future studies.

  Recruiting King's College Hospital NHS Trust · London, England · NCT07532785

• Amaze 6: Testing NNC0487-0111 to help people with overweight and knee osteoarthritis lose weight and ease pain

  This study tests whether weekly injections of NNC0487-0111 help adults with overweight or obesity and knee osteoarthritis lose weight and reduce knee pain compared with a placebo.

  Recruiting at 74 sites Phase 3 Novo Nordisk A/S · Escondido, California and 80 other locations · NCT07509307

• Comparing barbed and conventional wound closure after hip or knee replacement

  This study will test whether barbed sutures or conventional sutures lead to better wound healing and fewer complications for adults having primary or aseptic revision hip or knee replacement.

  Recruiting Umraniye Education and Research Hospital · Istanbul, Istanbul · NCT07439575

• Predicting knee cartilage wear and pain after early osteoarthritis or a recent ACL injury

  This project will try to create computer models that predict cartilage damage and pain over time for people with early knee osteoarthritis or an ACL injury within the past year.

  Recruiting at 2 sites Aalborg University · Aalborg, North Denmark and 1 other locations · NCT07134244

• Nurse-led telehealth versus in-person follow-up after total knee replacement

  This study will test whether nurse-led telehealth visits using a mobile app can catch complications and support recovery as well as in-person nurse visits for adults after their first total knee replacement.

  Recruiting Hospital Authority, Hong Kong · Hong Kong · NCT07058623

• Navigated total knee replacement using OrthoPilot pheno4u TKA Level 1

  This project will test whether the OrthoPilot pheno4u TKA Level 1 navigation software improves the accuracy and safety of navigated total knee replacement for adults (18–80) with osteoarthritis or other knee joint problems.

  Recruiting Aesculap AG · Šumperk and 3 other locations · NCT06955481

• Gut bacteria and knee implants: comparing people with well-functioning vs. revision total knee replacements

  This study tests whether the gut microbiome differs between people with a knee replacement that works well and those who need a revision surgery.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT06951477

• Low-dose radiation treatment for knee osteoarthritis

  This trial will test whether low-dose radiotherapy reduces pain in people aged 50–85 with symptomatic knee osteoarthritis compared with a sham procedure.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06887829

• Robot-assisted total knee replacement for osteoarthritis

  This study tests if using a robot to help with knee replacement surgery can lead to better results and happier patients compared to traditional methods for those with severe knee osteoarthritis.

  Recruiting The First Affiliated Hospital of University of Science and Technology of China · Hefei, Anhui · NCT06856356

• Comparing a new knee treatment to non-surgical options for knee osteoarthritis

  This study is testing a new knee treatment called the MISHA Knee System to see if it helps people with knee osteoarthritis feel better compared to standard non-surgical options.

  Recruiting at 6 sites Moximed · Davis, California and 8 other locations · NCT06843980

• Using interferential current with exercise for knee osteoarthritis

  This study is testing if adding a special electrical treatment to exercise can help people with knee osteoarthritis feel less pain and move better.

  Recruiting University of Nove de Julho · São Paulo · NCT06744036

• Single knee injection of donor-engineered gum cells for moderate knee osteoarthritis

  This will try a single injection of donor-derived engineered gingival fibroblasts into the knee to see if it is safe and helps people aged 40+ with moderate knee osteoarthritis.

  Recruiting Phase 1 Scarcell Therapeutics S.A.S. · Oxford · NCT06690710

• Can non-surgical, targeted multimodal care delay or avoid total knee replacement?

  This trial tests whether a comprehensive medical and lifestyle approach can delay or avoid knee replacement in adults with osteoarthritis who were advised to consider surgery.

  Recruiting at 2 sites University Hospital, Brest · Amiens and 20 other locations · NCT06643845

• Injections of Wharton's Jelly Allograft for Knee Osteoarthritis

  This study is testing whether injections of Wharton's Jelly can safely help people with knee osteoarthritis feel less pain and move better.

  Recruiting at 5 sites Early Phase 1 R3 Medical Research · Scottsdale, Arizona and 4 other locations · NCT06608134

• Evaluating colchicine's effect on knee and hip replacements in osteoarthritis patients

  This study is testing if taking colchicine every day can help people with osteoarthritis avoid needing knee or hip replacement surgery.

  Recruiting Phase 3 Sint Maartenskliniek · Nijmegen · NCT06578182

• Understanding knee tissue health and movement

  This project will use MRI and gait analysis to see if detailed imaging and movement testing can better characterize knee pain and early cartilage damage in people with mild-to-moderate osteoarthritis.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT06490770

• Maintaining knee improvement after physical therapy for Veterans

  This trial tests whether gamified social incentives and optional health coaching help Veterans with knee osteoarthritis stick with prescribed exercises and stay more active after physical therapy.

  Recruiting Phase 3 VA Office of Research and Development · Birmingham, Alabama and 4 other locations · NCT06488144

• Comparing Zilretta and Kenalog for knee osteoarthritis in patients with type 2 diabetes

  This study is testing whether two different types of knee injections can help people with knee osteoarthritis and type 2 diabetes manage their symptoms while keeping their blood sugar levels stable.

  Recruiting Phase 4 University of Kansas Medical Center · Kansas City, Kansas · NCT06478186

• National Registry for Artery Embolization to Treat Chronic Pain

  This study is testing if a procedure that blocks blood flow to painful areas can help people with chronic pain from osteoarthritis and other conditions feel better.

  Recruiting at 2 sites Vascular Solutions of North Carolina · Cary, North Carolina and 1 other locations · NCT06477965

• Using exosomes from stem cells to treat knee osteoarthritis

  This study tests whether exosomes from stem cells can help people with knee osteoarthritis feel less pain and improve their knee function.

  Recruiting Isfahan University of Medical Sciences · Isfahan · NCT06466850

• Using CBD to treat knee osteoarthritis pain

  This study is testing if CBD can help relieve knee pain for adults with osteoarthritis who are struggling with moderate to severe discomfort.

  Recruiting Phase 1/2 University of Florida · Gainesville, Florida · NCT06414473

• Examining biomarkers in osteoarthritic thumb joints

  This study is testing how certain markers in the thumb joints of people with osteoarthritis relate to their overall health and comparing them to knee joints, while also looking at grip strength and pain before and after surgery.

  Recruiting Region Skane · Malmö, Skåne County and 1 other locations · NCT06370312

• Personalized rehabilitation care for joint replacement patients

  This study is testing whether an AI tool can help create personalized rehab plans for people recovering from hip and knee joint replacement surgeries.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Italia · NCT06249958

• Using cannabidiol to reduce opioid use after knee replacement surgery

  This study tests if taking cannabidiol (CBD) daily can help people use less opioid pain medication after knee replacement surgery.

  Recruiting Phase 2 University of Michigan · Ann Arbor, Michigan and 1 other locations · NCT06234631

• Training to change calf muscle activation in people with knee osteoarthritis

  This study tests if giving real-time feedback on calf muscle use can help people with knee osteoarthritis walk better and feel less pain.

  Recruiting Stanford University · Stanford, California · NCT06208631

• Preventing osteoarthritis after an ACL tear

  This study is testing if a 6-month online education and exercise program can help young people who have had ACL surgery prevent osteoarthritis and improve their knee health.

  Recruiting at 2 sites University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT06195423

• Chronic pain education program for knee osteoarthritis

  This study is testing if adding a chronic pain education program to exercise can help people with knee osteoarthritis feel better and move more easily.

  Recruiting University of Nove de Julho · São Paulo · NCT06187038

• Effects of TENS and exercise on knee osteoarthritis

  This study tests if combining TENS therapy with exercise can help people over 40 with knee osteoarthritis feel less pain and move better.

  Recruiting University of Nove de Julho · São Paulo · NCT06184451

• Comparing two techniques for total knee prosthesis installation

  This study is testing two different ways to install knee replacements to see which method helps patients feel better and have fewer problems after surgery.

  Recruiting Clinique du Sport, Bordeaux Mérignac · Mérignac · NCT06158646

• Improving sleep to reduce pain after joint surgery

  This study is testing if helping people with insomnia sleep better before knee or hip surgery can reduce their pain after the operation.

  Recruiting Uppsala University · Uppsala, Uppland · NCT06145516

• Surgery to remove synovium in the quadriceps tendon to reduce knee crepitus after total knee replacement

  This study is testing if removing a part of the tissue around the quadriceps tendon can help reduce the annoying popping or crackling sound in the knee after total knee replacement surgery.

  Recruiting Gangnam Severance Hospital · Seoul, GangnamGu · NCT06129214

• Using metformin to reduce knee pain after ACL surgery

  This study is testing if metformin can help reduce knee pain and prevent arthritis in people recovering from ACL surgery.

  Recruiting at 9 sites Phase 2 Brigham and Women's Hospital · Atlanta, Georgia and 8 other locations · NCT06096259

• Reducing oxidative stress to prevent chronic pain after knee surgery

  This study is testing if a special antioxidant can help people who have knee surgery feel less pain and recover better.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06083480

• Impact of an anti-inflammatory diet on knee osteoarthritis

  This study is testing if following an anti-inflammatory diet can help people with knee osteoarthritis feel better and improve their symptoms.

  Recruiting University of California, San Diego · San Diego, California · NCT06080347

• Using L-arginine to relieve knee osteoarthritis pain

  This study is testing if L-arginine, a nutritional supplement, can help relieve knee pain for people with osteoarthritis.

  Recruiting Xiangya Hospital of Central South University · Changsha, Hunan · NCT06054633

• Comparing different treatments for chronic pain conditions

  This study is testing different treatments for chronic pain conditions like osteoarthritis and diabetic neuropathy to see which ones work better than a placebo.

  Recruiting at 36 sites Phase 2 Eli Lilly and Company · Birmingham, Alabama and 63 other locations · NCT05986292

• Comparing two methods for total knee replacement surgery

  This study is testing two different knee replacement surgery methods to see if they both help patients recover and feel satisfied with their results.

  Recruiting Aesculap AG · Ulm, Baden-Wurttemberg · NCT05980442

• Preventing knee osteoarthritis through diet and exercise in obese women over 50

  This study is testing if a weight loss diet and exercise can help prevent knee osteoarthritis in obese women over 50 who don’t have much knee pain.

  Recruiting at 3 sites Wake Forest University Health Sciences · Boston, Massachusetts and 3 other locations · NCT05946044

• Evaluating Joint Line Restoration in Severe Knee Osteoarthritis

  This study is testing the best way to find the joint line in older patients with severe knee arthritis to improve their knee surgery results and overall satisfaction.

  Recruiting Saglik Bilimleri Universitesi · Ankara · NCT05936814

• Knee osteotomy with meniscus transplantation for knee osteoarthritis

  This study is testing if adding a meniscus transplant to knee surgery helps people with knee osteoarthritis feel better and move easier compared to just the knee surgery alone.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT05840887

• Examining the impact of synovectomy on pain relief after knee replacement surgery

  This study is testing if removing inflamed tissue during knee replacement surgery can help people with osteoarthritis feel less pain and be happier with their results.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT05800457

• Helping osteoarthritis patients walk with NSAIDs

  This study is testing a new program that combines special exercises and occasional use of pain relief medications to help people with hip or knee osteoarthritis walk better.

  Recruiting Phase 4 University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT05761015

• Targeting abnormal blood flow to treat chronic joint pain in veterans

  This study is testing if treating abnormal blood flow in the joints can help veterans with chronic pain and osteoarthritis feel better.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT05700682

• Effect of an anti-inflammatory diet on knee osteoarthritis

  This study is testing whether following an anti-inflammatory diet can help people with knee osteoarthritis feel less pain and improve their joint health.

  Recruiting University of California, San Diego · La Jolla, California · NCT05559463

• Comparing autologous therapies for knee osteoarthritis treatment

  This study is testing whether two types of treatments using your own cells can help people with knee osteoarthritis feel less pain and move better compared to a saline placebo.

  Recruiting Phase 2/3 University Health Network, Toronto · Toronto, Ontario and 1 other locations · NCT05517434

• Effects of cannabinoids on knee osteoarthritis pain

  This study is testing if daily treatment with THC, CBD, or both can help people with knee osteoarthritis feel less pain and improve their symptoms.

  Recruiting Phase 2 University of Michigan · Ann Arbor, Michigan · NCT04992624

• Effects of Vibration on Knee Health After ACL Surgery

  This study is testing if adding vibration therapy to regular rehab can help people recovering from ACL surgery have better knee health and lower the chance of future injuries.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina and 1 other locations · NCT04875052

• Comparison of two knee implant designs for total knee replacement

  This study is testing which of two different knee implant designs helps people who have knee replacement surgery feel better and be more satisfied afterward.

  Recruiting LifeBridge Health · Baltimore, Maryland · NCT04814082

• Knee registry for patients receiving knee treatment

  This study collects information from patients getting knee treatment at a clinic to see how their knee function, pain, and mobility change before and after treatment.

  Recruiting UMC Utrecht · Utrecht · NCT04364334

• Evaluating outcomes of uncemented ATTUNE knee replacements

  This study is testing how well the uncemented ATTUNE knee replacement works for people with severe knee arthritis and how satisfied they are with the results.

  Recruiting Spaarne Gasthuis · Hoofddorp, North Holland · NCT04247672

• Comparing NAVIO system to traditional methods for knee replacement

  This study is testing if a new robotic system for knee replacement can help people with knee arthritis feel better and recover faster compared to traditional methods.

  Recruiting Sint-Trudo Hospital · Sint-Truiden, Limburg · NCT04230616

• Investigating exercise therapy and soft braces for knee osteoarthritis

  This study is testing whether exercise therapy and using a soft knee brace can help people with knee osteoarthritis feel less pain and improve their recovery.

  Recruiting University College of Northern Denmark · Aalborg, Nothern · NCT03949400

• Comparing fast track and standard care for total knee replacement

  This study is testing if a quicker recovery plan for knee replacement surgery helps patients feel better and recover faster compared to the usual care.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT03869996

• Low-impact exercise program for joint pain relief

  This study is testing if joining low-impact exercise classes can help people with knee, hip, and ankle pain from osteoarthritis feel better and move easier.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT03711773

• Using stem cells to treat knee osteoarthritis

  This study is testing if injections of stem cells from umbilical cords can help people with knee osteoarthritis feel better and improve their knee function.

  Recruiting Phase 2 Sclnow Biotechnology Co., Ltd. · Changsha, Hunan · NCT03383081

• Registry for Physica Total Knee Replacement

  This study is testing how well the Physica knee implant works for people getting total knee replacements over the next 10 years.

  Recruiting at 3 sites Limacorporate S.p.a · Rancho Mirage, California and 4 other locations · NCT03048201

• Ultrasound-guided pulsed radiofrequency treatment for knee osteoarthritis

  This study is testing whether a new ultrasound-guided treatment for knee pain can help people with chronic knee osteoarthritis feel better and use less pain medication.

  Recruiting Hospital Son Llatzer · Palma, Balear Islands · NCT02915120

Related topics

Quick answers

How many Osteoarthritis, Knee clinical trials are recruiting right now?

66, as of November 12, 2026. 4 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in United States (24 trials), Turkey (Türkiye) (5 trials), Italy (5 trials), Canada (5 trials), Denmark (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 3: 3, Phase 4: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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