Condition

Osteoarthritis (OA) of the Knee clinical trials and research

• 29Clinical trials
• 12Countries

Newest Osteoarthritis (OA) of the Knee clinical trials

All recruiting trials (29)

• Medial knee osteoarthritis: inside vs outside corticosteroid injection

  This study tests whether injecting a steroid inside the knee joint leads to different pain results than injecting it on the outside of the knee in people with medial knee osteoarthritis.

  Recruiting at 5 sites University of Chicago · Bolingbrook, Illinois and 4 other locations · NCT07804446

• Platelet-rich plasma added to hyaluronic acid for knee osteoarthritis

  This study tests whether a single injection of hyaluronic acid plus autologous platelet-rich plasma helps reduce knee OA symptoms more than hyaluronic acid alone in adults with moderate knee OA.

  Recruiting Implai Sp z o.o · Warsaw, Masovian Voivodeship · NCT07785401

• Hyaluronic Acid Plus PRP Injection for Knee Osteoarthritis

  This study tests whether a single HA injection combined with a patient’s own PRP is better at easing knee OA pain than HA alone.

  Recruiting Implai Sp z o.o · Chełm, Lublin Voivodeship · NCT07784907

• Long-acting local pain medicine after knee replacement

  This study tests whether a new extended-release pain medicine (Zynrelef) given around the knee during total knee replacement can reduce pain after surgery better or as well as standard injections or nerve blocks.

  Recruiting Phase 4 Henry Ford Health System · Grosse Pointe Farms, Michigan · NCT07775248

• Choose to Move Replacement Ready for OA patients waiting for hip or knee replacement

  This program tests a tailored, online version of a 3-month activity and social-connection plan for older adults with hip or knee osteoarthritis who are waiting for joint replacement surgery to see if it improves physical activity and health while they wait.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07696650

• Modular powered knee braces to help move better and reduce knee pain

  A device with partial motor support is being tested in adults with knee OA to see if it can ease pain and reduce effort during daily activities.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07673328

• Percutaneous nerve stimulation for knee osteoarthritis

  A device is used to send tiny electrical impulses to nerves around the knee to see if it reduces pain for adults with moderate to severe knee OA who have not had relief from other treatments.

  Recruiting Tanta University · Tanta · NCT07637682

• Knee injury and degeneration in real-world care

  This study follows patients with knee injuries or osteoarthritis to see how they recover over 2 years when they get standard care.

  Recruiting Ningbo No.2 Hospital · Ningbo, Zhejiang · NCT07592871

• Preoperative Genicular Nerve Block for Knee Replacement

  This study tests whether giving a genicular nerve block before knee replacement can reduce pain after surgery and lower opioid use.

  Recruiting Helse Møre og Romsdal HF · Hjelset, Møre og Romsdal · NCT07589127

• Imageless vs. image-based navigation in robot-assisted knee replacement

  This study tests whether imageless navigation is as good as image-based navigation for robotic-assisted total knee replacement in people with knee osteoarthritis.

  Recruiting Medical University of Warsaw · Warsaw, Mazovian · NCT07522489

• Post-Operative Pain Relief with Zynrelef vs Periarticular Injections in Robot-Assisted Knee Replacement

  This study tests whether the Zynrelef extended-release periarticular injection can reduce pain and opioid use after robot-assisted total knee arthroplasty compared with standard periarticular injections.

  Recruiting Phase 4 Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Cranberry Township, Pennsylvania · NCT07430085

• Virtual reality versus traditional relaxation to ease pain and improve sleep after hip or knee replacement

  This will test whether relaxation using virtual reality or traditional relaxation works better to reduce pain and improve sleep in adults after hip or knee replacement.

  Recruiting Bartın Unıversity · Bartın, Center · NCT07354542

• Herbal combination (Boswellia, turmeric, grape extract) for hip or knee osteoarthritis

  This study will test whether a daily herbal supplement containing Boswellia serrata, turmeric (curcumin), and grape extract (Vitis vinifera) reduces pain and improves function in adults with hip or knee osteoarthritis.

  Recruiting Middlesex University · London · NCT07324746

• Mobithron Advance for knee osteoarthritis: long-term effects

  This study tests whether taking Mobithron Advance daily for a year can slow knee OA progression and improve symptoms in adults over 50.

  Recruiting Early Phase 1 Universiti Sains Malaysia · Kota Bharu, Kelantan · NCT07323745

• Functional electrical stimulation versus exercise for strengthening the quadriceps in knee osteoarthritis

  This project will try functional electrical stimulation (FES) versus a supervised exercise program to see which better builds quadriceps strength and improves pain, walking, and quality of life for people aged 50–65 with moderate knee osteoarthritis.

  Recruiting Ankara City Hospital Bilkent · Ankara, Ankara and 1 other locations · NCT07309003

• Platelet-rich plasma injections for joint and tendon problems

  This project will test whether platelet-rich plasma (PRP) injections help people with osteoarthritis and other musculoskeletal conditions reduce pain and improve function over one year.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07231471

• Focused ultrasound nerve treatment for medial knee osteoarthritis pain

  This study will try focused ultrasound delivered through the skin to disrupt a small medial knee nerve and reduce chronic osteoarthritis pain in adults with moderate-to-severe medial knee pain.

  Recruiting FUSMobile Inc. · North York, Ontario · NCT07178951

• Choose to Move Replacement Ready for people waiting for hip or knee replacement

  This project will test whether the Choose to Move Replacement Ready program helps older adults on hip or knee replacement waitlists increase physical activity, improve mobility, and support psychosocial health.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07069179

• Weight loss, exercise, and metformin for knee osteoarthritis in overweight adults

  This study tests whether adding metformin to diet and exercise can reduce knee pain and body weight in adults with overweight or obesity and knee osteoarthritis who are considering knee replacement.

  Recruiting Early Phase 1 The University of Hong Kong · Hong Kong, Sandy Bay · NCT07065591

• Robotic Mako cementless versus cemented total knee replacement

  This study will test whether robotic Mako cementless or cemented knee replacements work better for adults having a primary total knee replacement for osteoarthritis.

  Recruiting University College, London · London · NCT06929871

• Adding bone marrow aspirate to knee arthroscopy for meniscus and cartilage injuries

  This trial will test whether giving a small bone marrow aspirate injection during knee arthroscopy helps adults (18–64) with meniscal tears or focal cartilage damage have less pain and better knee function.

  Recruiting Hospital for Special Surgery, New York · New York, New York · NCT06893302

• Assessing the safety of PCRX-201 for knee osteoarthritis pain relief

  This study is testing a new gene therapy called PCRX-201 to see if it can safely relieve knee pain in people aged 45 to 80 with osteoarthritis.

  Recruiting at 3 sites Phase 2 Pacira Pharmaceuticals, Inc · Birmingham, Alabama and 39 other locations · NCT06884865

• Corticosteroid injection for knee surgery patients

  This study is testing if giving corticosteroid injections to the other knee can help people with both knees affected by osteoarthritis recover better after knee surgery.

  Recruiting Phase 1/2 Unity Health Toronto · Toronto, Ontario · NCT06809998

• Acupuncture treatment for knee osteoarthritis

  This study is testing if acupuncture can help relieve knee pain and improve movement in people with knee osteoarthritis.

  Recruiting Jiangxi University of Traditional Chinese Medicine · Nanchang, Jiangxi · NCT06805188

• Non-invasive treatment for knee osteoarthritis using pulsed radiofrequency acupuncture

  This study is testing a new, non-invasive acupuncture treatment combined with rehab to see if it can help people aged 45 to 85 with knee osteoarthritis feel less pain and get more active.

  Recruiting Shin Kong Wu Ho-Su Memorial Hospital · Taipei, State · NCT06702046

• Pharmacist and physiotherapist care for early knee osteoarthritis

  This project will test whether pharmacist-led screening and referral combined with physiotherapy can help people over 50 with early knee osteoarthritis manage pain and improve function.

  Recruiting University of Alberta · Sherwood Park, Alberta · NCT06681142

• Using glucocorticoids to relieve acute osteoarthritis pain in the emergency department

  This study is testing if adding glucocorticoids to regular pain medications can help adults with sudden osteoarthritis pain feel better in the emergency department.

  Recruiting Phase 4 WellSpan Health · York, Pennsylvania · NCT06603662

• Personalized 12-week digital exercise program to correct knee movement after ACL reconstruction

  This program will try a 12-week sensor-guided exercise plan for adults 8–12 weeks after ACL reconstruction to correct harmful knee movements and reduce joint inflammation that can lead to early knee osteoarthritis.

  Recruiting at 2 sites Charite University, Berlin, Germany · Berlin and 1 other locations · NCT06596824

• Knee Osteoarthritis: comparing saline, PRP, and PL injections

  This study tests whether saline, platelet-rich plasma, or platelet lysate injections can relieve pain and improve function in people with knee OA.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT03734900

Related topics

Quick answers

How many Osteoarthritis (OA) of the Knee clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (8 trials), Canada (5 trials), Poland (3 trials), China (2 trials), Turkey (Türkiye) (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Early Phase 1: 2, Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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