Using low-dose radiation to treat osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effectiveness of low-dose radiation therapy (LDRT) in treating osteoarthritis, a common degenerative joint condition. It is a prospective, placebo-controlled, double-blind, randomized trial that includes patients with newly diagnosed or existing arthrosis in various joints such as fingers, wrists, and knees. Participants will receive either LDRT or a placebo treatment, and their pain relief will be assessed using a visual analog scale, alongside monitoring immunological changes. The goal is to provide evidence for the clinical benefits of LDRT compared to standard therapies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed osteoarthritis according to ACR criteria (exclusion of other other arthritides and chronic rheumatoid arthritis via laboratory tests):

  * Finger and wrist osteoarthritis
  * Elbow arthrosis
  * Shoulder arthrosis
  * Knee arthrosis
  * Ankle and foot joint arthrosis
* First time application of low-dose radiotherapy (LDRT) of the affected joint.
* Willingness to cooperate and accessibility of the patients (geographical proximity) for treatment and Follow-up care

Exclusion Criteria:

* Patients with tumor diseases
* People capable of childbearing or procreation who do not take consistent contraceptive measures during therapy
* Persistent drug, medication or alcohol abuse
* Patients for whom, in the physician's judgment, participation is not justifiable with regard to their well-being due to temporary withdrawal of standard medication.
* Patients in whom the diagnosis of osteoarthritis of the affected joint cannot be made without doubt. To establish the diagnosis, the guidelines of the American College of Rheumatology (ACR) are followed.
* Earlier radiation therapy for treatment of cancer

Where it's running

• Department of Radiation Oncology, Universitätsklinikum Erlangen
  Erlangen, Bavaria, Germany Recruiting

Study contacts

• Principal investigator: Benjamin Frey, PD Dr.-Ing. — Translational Radiobiology, Department of Radiation Oncology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg
• Study coordinator: Benjamin Frey, PD Dr.-Ing.
• Email: benjamin.frey@uk-erlangen.de
• Phone: +49 9131 85

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.