Condition

Osteo Arthritis Knee clinical trials and research

• 20Clinical trials
• 13Countries

Newest Osteo Arthritis Knee clinical trials

All recruiting trials (20)

• Arthrosamid versus steroid injections for managing knee osteoarthritis.

  This trial will test whether a single Arthrosamid hydrogel injection works better than a standard steroid plus local anesthetic injection for adults with symptomatic knee osteoarthritis.

  Recruiting Phase 4 Cappagh National Orthopaedic Hospital · Dublin, Dublin · NCT07489521

• Platelet-rich plasma plus hyaluronic acid injections for knee osteoarthritis

  We will try a single injection of platelet-rich plasma plus hyaluronic acid, platelet-rich plasma alone, or hyaluronic acid alone to see which works best for adults (40–75) with unilateral knee osteoarthritis who still have pain after conservative treatment.

  Recruiting Istituto Ortopedico Rizzoli · Bologna and 1 other locations · NCT06685120

• Evaluating OA-SYS for knee osteoarthritis treatment

  This study is testing a new treatment called OA-SYS using adult stem cells to see if it can help people with moderate to severe knee osteoarthritis feel better and improve their knee function.

  Recruiting Phase 2 Ageless Biotech, Inc. · Las Vegas, Nevada · NCT06485843

• Using bioceramic materials to repair bone defects

  This study is testing if a new type of bioceramic implant can help people heal better from bone defects compared to a standard bone implant.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06249906

• Evaluating Metformin for Knee Osteoarthritis

  This study is testing if Metformin can help people aged 30 to 60 with knee osteoarthritis feel better and improve their joint function compared to another medication.

  Recruiting Phase 3 Tanta University · Damietta, New Damietta · NCT06231758

• Comparing the effects of a vegan diet to an omnivorous diet before knee surgery

  This study is testing whether a vegan diet for two weeks before knee surgery can help older adults with knee osteoarthritis build protein in their muscles and tissues better than a regular diet with meat.

  Recruiting at 2 sites Wageningen University · Arnhem and 1 other locations · NCT06130956

• Evaluation of the MISHA Knee System for treating knee osteoarthritis

  This study is testing a new knee treatment called the MISHA Knee System to see if it helps people with knee osteoarthritis feel less pain and improve their function over five years.

  Recruiting at 4 sites Moximed · Sonoma, California and 3 other locations · NCT06118892

• Improving pain management for knee surgery patients

  This study is testing if a new way of managing pain that combines savoring meditation with education about pain can help people with knee osteoarthritis feel better after knee surgery.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06038240

• Using AttraX Putty to reduce pain in knee osteotomy

  This study is testing if using AttraX Putty during knee surgery can help reduce pain after the operation for people with knee osteoarthritis.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT05992038

• Using a robotic system to adjust knee surgery in real-time

  This study is testing if a robotic system can help make real-time adjustments during knee surgery to improve outcomes for patients getting total knee replacements.

  Recruiting Zimmer Biomet · Fukuoka, Fukuoka · NCT05966519

• Examining fat tissue in the knee and thigh muscles of patients with osteoarthritis

  This study looks at fat tissue in the knees and thigh muscles of people with knee osteoarthritis to see how it affects muscle strength and the progression of the condition.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT05955976

• Gait rehabilitation using biofeedback for knee injuries

  This study is testing if real-time feedback on walking can help younger people who had knee surgery recover better and avoid early signs of osteoarthritis.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT05848622

• Fall prevention program for elderly after knee replacement

  This study tests if adding a fall prevention program to regular physical therapy can help older adults who have had knee replacement surgery stay safe from falls and improve their balance and movement.

  Recruiting Ministry of Health, Kuwait · Kuwait City · NCT05642260

• Using a smart ring to help recovery after knee replacement surgery

  This study tests if using a smart ring to track activity and sleep can help people recover better after knee replacement surgery for osteoarthritis.

  Recruiting Coxa, Hospital for Joint Replacement · Tampere, Pirkanmaa · NCT05599776

• Comparing two types of nerve blocks for pain management after knee surgery

  This study is testing whether a single injection of a nerve block can help control pain after knee surgery better than a continuous nerve block, while also allowing for easier movement and recovery.

  Recruiting Negovsky Reanimatology Research Institute · Moscow · NCT05487053

• Comparing total knee replacement to robotic-assisted partial knee replacement

  This study is testing whether robotic-assisted partial knee replacement helps people with severe knee arthritis recover better and feel more functional than traditional total knee replacement.

  Recruiting NHS Lothian · Edinburgh, Lothian · NCT05290818

• Treatment for knee osteoarthritis using bone marrow aspirate concentrate

  This study is testing whether a treatment using concentrated bone marrow can help people with moderate to severe knee osteoarthritis feel less pain and improve their joint health before they have knee replacement surgery.

  Recruiting University of California, San Diego · La Jolla, California · NCT04716803

• Using patients' own cells to treat osteoarthritis

  This study is testing whether using patients' own stem cells and platelet-rich plasma can help treat osteoarthritis better than traditional methods.

  Recruiting Healeon Medical Inc · Valencia, California and 1 other locations · NCT04238143

• Comparing two methods of knee replacement surgery

  This study tests whether a robotic knee replacement surgery works better than a traditional method for people with knee osteoarthritis.

  Recruiting University College, London · London · NCT04095637

• Improving knee replacement outcomes using a pressure sensor for alignment

  This study tests if using a special pressure sensor during knee replacement surgery can help people with osteoarthritis walk better and feel more satisfied with their results compared to standard surgery.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT03286868

Related topics

Quick answers

How many Osteo Arthritis Knee clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (6 trials), United Kingdom (2 trials), Netherlands (2 trials), Ireland (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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