Condition

Osteoarthritis (OA) clinical trials and research

• 10Clinical trials
• 2NIH research projects
• 6Countries

Newest Osteoarthritis (OA) clinical trials

All recruiting trials (10)

• Medial knee osteoarthritis: inside vs outside corticosteroid injection

  This study tests whether injecting a steroid inside the knee joint leads to different pain results than injecting it on the outside of the knee in people with medial knee osteoarthritis.

  Recruiting at 5 sites University of Chicago · Bolingbrook, Illinois and 4 other locations · NCT07804446

• Choose to Move Replacement Ready for OA patients waiting for hip or knee replacement

  This program tests a tailored, online version of a 3-month activity and social-connection plan for older adults with hip or knee osteoarthritis who are waiting for joint replacement surgery to see if it improves physical activity and health while they wait.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07696650

• Observational Registry for Dezawa MuseCells Outcomes

  This project follows people who were treated with Dezawa MuseCells to see how they’re doing over 5 years using online surveys.

  Recruiting at 2 sites MuseCell Innovations Pte LTD · North Palm Beach, Florida and 1 other locations · NCT07645989

• Can robotic-assisted knee replacement with functional alignment improve outcomes vs. standard knee replacement?

  This trial tests whether using the VELYS robotic system during total knee replacement helps patients with knee osteoarthritis feel better and move more comfortably compared with conventional non-robotic surgery.

  Recruiting Golden Jubilee National Hospital · Glasgow, Scotland · NCT07551856

• Screening blood biomarkers for osteoarthritis diagnosis

  This project will test whether certain blood biomarkers can help diagnose osteoarthritis in people aged 40–70 who have had joint pain or stiffness for at least three months.

  Recruiting The First Affiliated Hospital of Xinxiang Medical College · Xinxiang, Henan · NCT07544823

• Post-Operative Pain Relief with Zynrelef vs Periarticular Injections in Robot-Assisted Knee Replacement

  This study tests whether the Zynrelef extended-release periarticular injection can reduce pain and opioid use after robot-assisted total knee arthroplasty compared with standard periarticular injections.

  Recruiting Phase 4 Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Cranberry Township, Pennsylvania · NCT07430085

• Impact of pre-operative sarcopenia on recovery after hip replacement in older adults

  This study tests whether low muscle mass and strength before hip replacement affect recovery in people 75 and older who have hip fracture or severe osteoarthritis.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07429955

• Herbal combination (Boswellia, turmeric, grape extract) for hip or knee osteoarthritis

  This study will test whether a daily herbal supplement containing Boswellia serrata, turmeric (curcumin), and grape extract (Vitis vinifera) reduces pain and improves function in adults with hip or knee osteoarthritis.

  Recruiting Middlesex University · London · NCT07324746

• Surgical repair of cartilage to prevent osteoarthritis later in life

  This project will see if surgical treatments for cartilage defects (such as ACI) reduce the chance of developing osteoarthritis later in people who had cartilage repair or alternative treatments.

  Recruiting at 2 sites Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust · Oswestry and 1 other locations · NCT07320118

• Platelet-rich plasma injections for joint and tendon problems

  This project will test whether platelet-rich plasma (PRP) injections help people with osteoarthritis and other musculoskeletal conditions reduce pain and improve function over one year.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07231471

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted OA treatment at disease sites using a prodrug that releases an antioxidant at the pain-affected joint

  A new prodrug approach delivers an antioxidant and anti-inflammatory drug directly to osteoarthritis-affected joints to reduce pain and damage with fewer side effects.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11371552

• Novel SRC kinase blocker to slow osteoarthritis and joint pain

  A new drug candidate that blocks a specific SRC kinase interaction is being tested to slow osteoarthritis progression and reduce joint pain.

  NIH research Reparris, INC. · Lancaster, United States · NIH-11311650

Related topics

Quick answers

How many Osteoarthritis (OA) clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (4 trials), United Kingdom (3 trials), China (1 trial), Canada (1 trial), Mexico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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