Genetics of Osteoarthritis and Recovery After Joint Replacement
Official title: Genetics of Osteoarthritis and Joint Replacement Recovery: Key to Precision Rehabilitation
Funded at Birmingham VA Medical Center · NIH-11418232 · Data updated 2026-11-12
A study looking at how genes affect osteoarthritis and recovery after hip or knee replacement to help tailor rehabilitation for veterans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Birmingham VA Medical Center NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2027 |
| NIH project number | 5I01RX002745-09 |
| Project ID | NIH-11418232 on NIH RePORTER |
Who could benefit from this research
✓Could help
Veterans with osteoarthritis who have undergone or are considering total hip or total knee replacement, and participants in the Million Veteran Program or UK Biobank with relevant genetic and health data.
✕Less likely to help
Patients without OA or who are not undergoing joint replacement may not directly benefit from this study.
What this research studies
This project focuses on understanding how genetic differences influence osteoarthritis and how patients recover after joint replacement, with a special emphasis on veterans. Researchers will use large veteran and UK biobank data to identify genetic factors that affect OA risk and post-surgery recovery. The goal is to inform personalized rehabilitation strategies that improve quality of life after hip or knee replacement. The work builds on prior findings about ancestry-specific genetics and aims to translate those insights into better, individualized care.
Why it matters
Potential benefit: If successful, the study could lead to personalized rehab plans that improve recovery and reduce pain after joint replacement.
How similar studies have gone: Previous work has shown genetic factors influence OA and recovery, but this project seeks to translate those findings into precision rehabilitation.
Where this research is happening
-
Birmingham VA Medical Center
Birmingham, United States Active
Researchers
- Principal investigator: Mcdonald Donnelly, Merry-Lynn Noelle — Birmingham VA Medical Center
- Study coordinator: Mcdonald Donnelly, Merry-Lynn Noelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.