Eloralintide for knee osteoarthritis pain in adults with overweight or obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Under a master protocol, two parallel Phase 3 studies will compare eloralintide to placebo in adults with knee osteoarthritis who are overweight or have obesity. Eligible participants with a BMI of 27 kg/m² or higher and qualifying knee symptoms will be enrolled and followed for about 75 weeks, including screening. The studies will collect measures of knee pain, physical function, weight change, and safety outcomes. Safety monitoring will include adverse event reporting and laboratory assessments throughout the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
* Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
* Have tried at least once to lose weight through diet but were unsuccessful
* Have osteoarthritis of the knee and at least one of the following conditions:

  * Be over 50 years old
  * Have morning knee stiffness that lasts about 30 minutes
  * Have a crackling or grinding sound or feeling in the knee

Exclusion Criteria:

* Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
* Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
* Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
* Have an active knee infection
* Have had within 90 days prior to screening:

  * heart attack
  * stroke
  * coronary artery revascularization
  * unstable angina, or
  * hospitalization due to congestive heart failure
* Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
* Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Where it's running

• AMR Clinical
  Mobile, Alabama, United States Recruiting
• Care Access - 801 South Power Road, Mesa
  Mesa, Arizona, United States Recruiting
• Elite Pain and Spine Institute - South Crimson Road
  Mesa, Arizona, United States Recruiting
• Elite Clinical Studies, LLC
  Phoenix, Arizona, United States Recruiting
• Tucson Orthopaedic Institute - North Wyatt Drive
  Tucson, Arizona, United States Recruiting
• Ark Clinical Research - Fountain Valley
  Fountain Valley, California, United States Recruiting

+97 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
• Email: LillyTrials@Lilly.com
• Phone: 317-615-4559

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.