Condition

Low Back Pain clinical trials and research

• 117Clinical trials
• 102NIH research projects
• 1New in 30 days
• 30Countries

Newest Low Back Pain clinical trials

All recruiting trials (117)

• A novel multi angular isometric lumbar exercise for chronic low back pain

  This trial tests MAILE, a new lumbar exercise method, to see if it helps adults with nonspecific chronic low back pain more than standard lumbar stabilization and core exercises.

  Recruiting Hamad Medical Corporation · Doha · NCT07908693

• Pain catastrophizing, fear of movement, and activity in postmenopausal women with chronic low back pain

  This observational study looks at how negative pain thoughts and fear of moving relate to how active postmenopausal women with long‑standing low back pain are.

  Recruiting Istanbul Medipol University Hospital · Istanbul, Istanbul · NCT07856498

• Analgesia boost from adding a sacral submultifidus block to SIJ injection

  This study tests whether adding a sacral submultifidus block to a standard image-guided sacroiliac joint injection provides better pain relief and function for adults with chronic SIJ‑related pain.

  Recruiting Fayoum University Hospital · Al Fayyum · NCT07814729

• Telerehabilitation after spine surgery

  This trial tests different ways of delivering post-operative instructions to people who had spinal decompression surgery to see how it affects recovery and healthcare use.

  Recruiting Kuopio University Hospital · Kuopio · NCT07795697

• How patient education helps people with chronic musculoskeletal pain stick to home exercise for pain relief

  A structured patient education program is tested to see if it helps people with chronic low back pain, knee osteoarthritis, and shoulder problems stick with their home exercise plan to relieve pain.

  Recruiting Imam Abdulrahman Bin Faisal University · Dammam, Eastern Province · NCT07764354

• Core endurance vs segmental stabilization for low back pain in recreational athletes

  This trial tests whether core endurance exercises or segmental stabilization exercises better help recreational athletes with non-specific low back pain.

  Recruiting Uskudar University · Istanbul · NCT07760103

• AI-driven rehabilitation vs traditional physical therapy for low back dysfunction

  This study tests whether an artificial intelligence–driven rehab program can improve pain, function, and quality of life more than standard physical therapy in adults with long-standing low back dysfunction.

  Recruiting Cairo University · Giza, Giza Governorate · NCT07749833

• Virtual reality plus pain science education for chronic low back pain

  This study tests whether adding virtual reality with pain education can help adults with chronic low back pain see less pain and worry less about movement.

  Recruiting Aveiro University · Amarante · NCT07742111

• AI symptom checks before visiting physical therapy: does it change spine care decisions?

  This study tests whether using AI symptom-checking tools like ChatGPT before a visit affects shared decision-making during the first physical therapy evaluation for adults with neck, back, or radicular spine problems.

  Recruiting Assiut University · Asyut · NCT07733752

• spray and stretch vs strain counter strain for non-specific low back pain

  This trial tests whether the spray and stretch technique or strain-counter strain better reduces pain and improves movement in people with non-specific low back pain.

  Recruiting Riphah International University · Multan, Punjab Province · NCT07729774

• Three CT Signs of Nerve-Root Suffering in Low-Back Sciatica: How Often They Occur in Patients Referred for CT-Guided Nerve-Root Infiltration

  This study tests whether three specific CT signs align with the nerve root causing symptoms in adults with low-back sciatica who are scheduled for CT-guided nerve-root infiltration.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, Alpes Maritimes · NCT07690449

• Relationship between how much of the arm is missing and balance, neck/back pain, daily activities, and reaction time in people with a unilateral upper limb amputation

  This study will see if the amount of arm loss relates to balance, neck and back pain, daily tasks, hand dexterity, and reaction time in adults who use a myoelectric or bionic prosthesis.

  Recruiting Hacettepe University · Ankara · NCT07677969

• Chronic low back pain: test LY4065967 vs. placebo

  This study tests whether LY4065967 is safe and helps reduce chronic low back pain compared to placebo in adults with long‑standing back pain.

  Recruiting at 34 sites Phase 2 Eli Lilly and Company · Birmingham, Alabama and 35 other locations · NCT07641504

• Sensorimotor training with a mobilized balance system for chronic low back pain

  This study tests whether sensorimotor training with the Huber 360 balance system helps people with chronic low back pain compared with a home exercise program.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara · NCT07603609

• AI-based prediction of five major diseases using integrated health data

  Researchers are testing an AI model to see if they can predict the onset of five major diseases in adults 30–65 by combining medical records with biospecimens and lifestyle data.

  Recruiting Asan Medical Center · Seoul, Seoul Special City · NCT07595718

• Catgut Embedding for Lumbar Spondylosis With Blood Stasis Syndrome (Vietnam)

  This trial tests whether catgut embedding can better reduce back pain and improve daily activities than electro-acupuncture in adults with chronic low back pain due to lumbar spondylosis and Blood Stasis syndrome.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City, Ho Chi Minh City · NCT07590050

• Core stabilization plus myofascial induction for postpartum low back pain

  This test tries whether adding myofascial induction therapy to core stabilization exercises helps women with postpartum low back pain.

  Recruiting Riphah International University · Sialkot, Punjab Province · NCT07576244

• Low Blood Flow Restriction Training for Nonspecific Low Back Pain

  This trial tests whether using low load blood flow restriction exercises can help improve hamstring strength, reduce pain, and lessen disability in adults with nonspecific low back pain.

  Recruiting Riphah International University · Islamabad · NCT07576101

• Common Pain Mechanisms in Migraine and Associated Neck and Lower Back Pain

  This study tests how migraine relates to neck and lower back pain and whether shared central pain processing plays a role in people with episodic or chronic migraine who also have neck or lower back pain.

  Recruiting Bozok University · Gaziantep, Merkez · NCT07567300

• Wearable MMG belt with haptics and games to motivate core exercises

  This trial will test whether a wearable mechanomyography (MMG) biofeedback belt with a haptic-enabled mobile app and game features helps adults with chronic non-specific low back pain perform core exercises, reduce pain, and lower disability over 8 weeks.

  Recruiting Imperial College London · London · NCT07555795

• Yoga Nidra, Yoga, or no intervention for chronic low back pain

  The study tests whether Yoga Nidra or Yoga help people with chronic low back pain more than doing nothing.

  Recruiting University of Central Florida · Orlando, Florida · NCT07543835

• Ultrasound-guided Pharmacopuncture for Spinal Pain in Korea

  This registry follows patients with spinal pain to see if ultrasound-guided pharmacopuncture is safe and helps reduce pain.

  Recruiting at 6 sites Jaseng Medical Foundation · Daejeon, Daejeon and 5 other locations · NCT07543692

• Educational video to boost TENS pain relief during exercises for acute low back pain

  This trial tries to see if adding a short educational video about how TENS works to standard TENS plus exercise helps adults with acute low back pain have less pain and better movement.

  Recruiting Cairo University · Giza, Giza Governorate · NCT07535047

• Comparing exercise, cognitive behavioral therapy for insomnia, and both for chronic musculoskeletal pain with poor sleep

  This project will test whether a 12-month home-based exercise program, CBT for insomnia, or their combination helps reduce pain and improve sleep in adults with chronic low back pain or hip/knee osteoarthritis who have poor sleep.

  Recruiting University of Sydney · San Antonio, Nevada and 3 other locations · NCT07532070

• Post-isometric relaxation versus active isolated stretching for piriformis syndrome

  We are testing whether post-isometric relaxation or active isolated stretching better reduces pain and improves movement in adults aged 20–55 with piriformis syndrome.

  Recruiting Foundation University Islamabad · Islamabad, Punjab Province · NCT07526012

• How different types of low back pain affect function and quality of life in people with ankylosing spondylitis.

  This single-visit project will see if different types of low back pain in adults with ankylosing spondylitis relate to pain severity, daily function, and quality of life.

  Recruiting Konya Beyhekim Training and Research Hospital · Konya, Selçuklu · NCT07510789

• How the core and shoulder function relate in people with chronic low back pain

  This study tests whether core stability and Transversus Abdominis (TrA) involvement affect upper body reach and scapular control in adults with chronic low back pain compared with healthy individuals.

  Recruiting Istanbul Saglik Bilimleri University · Ankara · NCT07474610

• Pilates for postural correction, core strength, and flexibility in young adults with non-specific low backache

  This trial tests whether a six-week, three-times-weekly Pilates program improves posture, core strength, and flexibility more than conventional therapy in 18–25-year-olds with non-specific low backache.

  Recruiting University of Health Sciences Lahore · Lahore, Punjab Province · NCT07467070

• Ultrasound-guided stabilization exercises for lumbosacral (low back) pain

  This trial will try using ultrasound biofeedback during stabilization exercises to see if it reduces pain and improves balance, mobility, and quality of life in adults aged 30–65 with chronic lumbosacral (low back) pain.

  Recruiting University of Rzeszow · Tarnów, Małopolska · NCT07463729

• How quickly basivertebral nerve ablation relieves vertebrogenic low back pain

  This study will follow people with vertebrogenic low back pain who are getting basivertebral nerve ablation to see how quickly and how much their pain and function improve over two years.

  Recruiting at 3 sites Yale University · Guilford, Connecticut and 2 other locations · NCT07433634

• Post-facilitation stretch vs. dry needling for hamstring tightness in chronic low back pain

  This study tests whether post-facilitation stretch or dry needling, alongside conventional therapy, helps people with chronic low back pain who have tight hamstrings.

  Recruiting Riphah International University · Peshawar, Khyber Pakhtunkhwa · NCT07426562

• Italian version of the Waddell Disability Index for chronic low back pain

  This project will test an Italian translation of the Waddell Disability Index to see if it reliably measures disability in adults with chronic low back pain.

  Recruiting at 2 sites Istituti Clinici Scientifici Maugeri SpA · Lissone, Milano and 1 other locations · NCT07413107

• Bone marrow concentrate injection added to lumbar microdiscectomy

  This trial tests whether adding a bone marrow aspirate concentrate injection during lumbar microdiscectomy helps adults recover better than surgery alone.

  Recruiting Weill Medical College of Cornell University · Manhattan, New York · NCT07386548

• Early rehabilitation after lumbar spinal fusion using dialogue and graded activity

  This trial tests a tailored physiotherapy package that combines conversation, education, and gradually increasing activity to help adults after lumbar spinal fusion see if they improve in activity, pain, and confidence.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Glostrup Municipality · NCT07378735

• TENS to relieve myofascial low back pain in adults.

  This study will try TENS five times a week for four weeks to see if it reduces pain and improves function in adults with myofascial low back pain.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT07368920

• Pilates for postnatal low back pain

  This program will test whether supervised Pilates plus a home exercise plan can reduce pain and improve function in postnatal women with chronic nonspecific low back pain.

  Recruiting Kafrelsheikh University · Kafr ash Shaykh, Kafrelsheikh · NCT07359144

• Sodium aescinate treatment for adult chronic low back pain

  This trial tests whether oral sodium aescinate tablets can reduce pain and improve function in adults aged 18–65 with chronic low back pain lasting at least 12 weeks and a pain score above 4.

  Recruiting Phase 1 Xijing Hospital · Xi'an, Shaanxi · NCT07339631

• Eight-Week Baduanjin for Chronic Low Back Pain in Office Workers

  A simple eight-week Baduanjin exercise program is tested to see if it can reduce back pain and improve function in office workers with long-standing low back pain.

  Recruiting Universiti Sains Malaysia · Xi'an, Shaanxi · NCT07338045

• Moderate-load eccentric core exercises versus Pilates for adults with non-specific low back pain

  This project will test whether moderate-load eccentric core exercises or Pilates work better to reduce pain and improve function in adults 18–45 with chronic non-specific low back pain.

  Recruiting Foundation University Islamabad · Islamabad, Punjab Province · NCT07332390

• Using Xsens wearable sensors to measure lumbar spine movement fluidity before and after rehabilitation

  This project will try whether wearable Xsens sensors can detect improvements in lumbar spine movement smoothness in adults aged 18–65 with chronic low back pain who undergo rehabilitation.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07327554

• Diaphragm release to reduce low back pain

  This trial will test whether adding manual diaphragm relaxation to core stabilization exercises helps adults with chronic non-specific low back pain have less pain and better function.

  Recruiting Karabuk University · Karabük · NCT07298109

• STEPPT: Connecting primary care patients with physical therapy

  This project will test whether the STEPPT program increases physical therapy referrals and attendance for Hispanic adults with neck or back pain seen at a community health center.

  Recruiting San Diego State University · San Diego, California · NCT07290361

• Pain Neuroscience Education with Sensory Discrimination Training for Chronic Low Back Pain

  A randomized study tests whether adding Sensory Discrimination Training to Pain Neuroscience Education and core exercises helps people with chronic low back pain more than Pain Neuroscience Education and core exercises alone.

  Recruiting Lahore University of Biological and Applied Sciences · Lahore · NCT07284407

• Office worker program to reduce low back pain and improve posture and core function

  This test tries whether a combination of exercise, posture education, and standing advice can reduce low back pain and improve posture, muscle function, ergonomics, stress, and quality of life for office workers with low back pain.

  Recruiting Universiti Teknologi Mara · Depok, West Java · NCT07250568

• Embedded emergency department physical therapy for adults with recent low back pain

  This project tests placing a physical therapist directly in the emergency department to see if it improves care for adults who come in with recent low back pain.

  Recruiting at 2 sites Northwestern University · Chicago, Illinois and 1 other locations · NCT07224945

• TeleYoga for Chronic Low Back Pain

  This program tests a virtual yoga and mindfulness approach to see if it helps adults with chronic low back pain.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT07216417

• Improving use of a mobile app for chronic low back pain

  This will test whether phone calls or text messages help people with chronic low back pain use a pain-management app more than the app's standard notifications.

  Recruiting Neuroscience Research Australia · Sydney, New South Wales · NCT07205991

• Low back pain relief with the Japet.W+ device

  A device called Japet.W+ is being tested to see if it can reduce pain for adults with chronic non-specific low back pain during regular use.

  Recruiting at 2 sites Japet Medical Devices · Clermont-Ferrand and 1 other locations · NCT07195422

• Time‑variant pulse spinal cord stimulation for chronic low back and leg pain

  This trial will test whether time‑variant pulse spinal cord stimulation using the Boston Scientific WaveWriter Alpha system can reduce chronic low back or leg pain in adults who have not found relief from other treatments.

  Recruiting at 7 sites Boston Scientific Corporation · Greenwood, Colorado and 6 other locations · NCT07190807

• Telephone versus in-person physiotherapy follow-up for lumbar spine surgery patients

  This will test whether physiotherapy follow-up by telephone works as well as in-person visits for patients who had lumbar spine surgery.

  Recruiting Aalborg University Hospital · Aalborg, Aalborg · NCT07173413

• Integrated healthy lifestyle and pain care for people with musculoskeletal conditions in rural areas

  Aiming to see if an in-person or a virtual, lifestyle-focused pain care program helps rural adults with musculoskeletal pain and lifestyle risks feel less impact from their pain.

  Recruiting at 2 sites University of Sydney · Coffs Harbour, New South Wales and 2 other locations · NCT07173335

• Adding osteopathic manipulation to VA care for chronic low back pain

  This trial will test whether adding osteopathic manipulative therapy—hands-on techniques that move muscles and joints—to usual VA care helps veterans with chronic low back pain.

  Recruiting Edward Hines Jr. VA Hospital · Hines, Illinois · NCT07161661

• Team-based program to improve primary care for adults with low back pain

  This project will test a multilevel program that helps GPs, physiotherapists, and occupational therapists follow guidelines, educate patients, and coordinate care for adults with low back pain.

  Recruiting at 2 sites Haute Ecole de Santé Vaud · Geneva, Canton of Geneva and 1 other locations · NCT07137065

• Comparing physiotherapy approaches for anterior pelvic tilt in non‑specific low back pain

  This tests whether four different physiotherapy programs help adults aged 20–40 with anterior pelvic tilt and mild-to-moderate non‑specific low back pain feel less pain and improve pelvic posture.

  Recruiting National Orthopedic and General Hospital · Chak Eighty-seven -Twelve Left, Punjab Province · NCT07098741

• Piriformis-focused and Swedish massage for healthcare workers with low back pain

  This trial will try piriformis-targeted and Swedish massage to see if they reduce chronic low back pain in healthcare workers aged 30–65.

  Recruiting Wroclaw University of Health and Sport Sciences · Wroclaw, Lower Silesian Voivodeship · NCT07094997

• Cutibacterium acnes and degenerative lumbar disc disease after microdiscectomy

  This project will try to see if the bacterium Cutibacterium acnes is linked to degenerative lumbar disc disease in adults who had microdiscectomy for lumbar disc herniation.

  Recruiting Masaryk University · Brno · NCT07085247

• Which factors predict success of rehab for chronic low back pain?

  This project will test whether physical tests, psychosocial measures, and biomarkers can predict who with chronic low back pain will benefit from a mobility skills rehabilitation session.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Clermont-Ferrand, Auvergne and 5 other locations · NCT07051772

• Online versus in-person supervised Pilates for non-specific low back pain

  This program will test whether supervised Pilates delivered online works as well as in-person supervised Pilates for adults aged 18–40 with chronic non-specific low back pain.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07026097

• Sound wave therapy plus standard physiotherapy for mechanical low back pain

  This trial will test whether adding sound wave therapy to standard physiotherapy helps adults aged 18–45 with chronic mechanical low back pain feel less pain and move better.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07026058

• Post‑isometric relaxation versus post‑facilitation stretch for chronic low back pain

  This project will try two manual muscle‑stretching techniques—post‑isometric relaxation and post‑facilitation stretch—along with standard physical therapy in adults 18–45 with chronic low back pain to see which reduces pain and disability more.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07026045

• Thigh blood-flow restriction for knee osteoarthritis and low back pain

  This trial will test whether repeated brief full thigh blood-flow restriction every other day for two weeks helps people over 50 with knee osteoarthritis and low back pain improve function.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07003113

• Evaluating Sedante Neo Therapy for Low Back Pain Relief

  This study is testing if Sedante Neo therapy can help people with low back pain feel better and move more easily while improving their quality of life.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT06987175

• Evaluating Feldenkrais and Otago exercises for low back pain relief

  This study is testing whether the Feldenkrais Method or Otago exercises can help adults aged 18 to 65 with chronic low back pain feel better and improve their daily activities.

  Recruiting Riphah International University · Lahore · NCT06985849

• Mobile app delivering pain education and clinical hypnosis for chronic low back pain

  This study will test whether a mobile app that provides pain education and clinical hypnosis can reduce pain and disability in people with non-specific chronic low back pain who are seeing a GP in Australia.

  Recruiting Neuroscience Research Australia · Randwick, New South Wales · NCT06984354

• Exercise after caudal epidural steroid injection for lumbar disc herniation

  This trial will test whether adding aerobic or core‑stabilisation exercise to standard physiotherapy after a caudal epidural steroid injection helps adults with MRI‑confirmed lumbar disc herniation reduce pain and improve function.

  Recruiting at 2 sites Çankırı Karatekin University · Çankırı and 2 other locations · NCT06956664

• Comparing McKenzie technique and manual therapy for low back pain relief

  This study is testing whether the McKenzie technique or manual therapy works better to relieve low back pain and improve movement for people with this condition.

  Recruiting Riphah International University · Malakand, KPK · NCT06955117

• Personalized back training program for low back pain relief

  This study is testing whether a personalized back exercise program can help people with long-term low back pain feel better and move more easily compared to regular exercises.

  Recruiting Universität Luzern · Lucerne, Canton of Lucerne · NCT06938568

• Tablet-based music vs oxygen–nitrous oxide gas to reduce anxiety during CT-guided lumbar injections

  This test tries to see if a tablet music program can calm adults with low back pain and anxiety during CT-guided lumbar injections as well as the usual oxygen–nitrous oxide gas (EMONO).

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes · NCT06928740

• Global Postural Reeducation (GPR) for chronic non-specific low back pain

  This trial will test whether weekly Global Postural Reeducation (GPR) sessions help adults aged 18–55 with chronic non-specific low back pain reduce pain and improve posture.

  Recruiting Federal University of Bahia · Salvador, Estado de Bahia · NCT06928597

• Program for managing chronic low back pain

  This study is testing a new program designed to help people with chronic low back pain by training local clinicians in Edmonton to use and improve it for English-speaking patients.

  Recruiting University of Alberta · Edmonton, Alberta · NCT06924671

• Group hydrotherapy for athletes with chronic low back pain

  This program will test whether a six-week group hydrotherapy course helps athletes with chronic low back pain reduce pain and improve function.

  Recruiting University of Haifa · Netanya · NCT06894355

• Comparing Graston and Active Release Techniques for Low Back Pain in Women

  This study is testing whether the Graston Technique or Active Release Technique works better to relieve low back pain in women aged 25 to 50.

  Recruiting Riphah International University · Sialkot, Punjab Province · NCT06877767

• Ultrasound-guided neuromodulation to help gluteus muscle weakness after a back pain episode

  This trial tests whether ultrasound-guided percutaneous electrical nerve/nerve-point stimulation of the gluteal muscles helps people with recent low back pain and related muscle dysfunction, using two different stimulation frequencies.

  Recruiting Universidad de Zaragoza · Sabadell, Barcelona · NCT06873386

• Understanding the impact of disability and fear on quality of life in chronic low back pain

  This study looks at how disability and fear affect the quality of life for people aged 18-50 with chronic low back pain to see how these factors are connected.

  Recruiting Istanbul Arel University · Istanbul, Buyukcekmece · NCT06869668

• Comparing cost-effective care models for musculoskeletal disorders

  This study is testing a new way of treating musculoskeletal disorders that focuses on patient education first to see if it works better and costs less than standard care.

  Recruiting Laval University · Québec, Quebec · NCT06832852

• Needle-free ear cryo-stimulation and brain imaging for chronic low back pain

  This trial will test whether needle-free ear cryo-stimulation can change brain activity and reduce pain in adults who have had daily low back pain for at least six months.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06825390

• Assessment and treatment of low back pain using ultrasound and osteopathic techniques

  This study is trying to see if using ultrasound and hands-on techniques can help people with low back pain by looking closely at a specific part of the back called the thoracolumbar fascia.

  Recruiting Edward Via Virginia College of Osteopathic Medicine · Blacksburg, Virginia · NCT06818175

• Investigating factors affecting pregnancy-related lumbopelvic pain

  This study is trying to find out what causes pregnancy-related back and pelvic pain in women during their third trimester and after giving birth by looking at physical and emotional factors.

  Recruiting at 2 sites Hasselt University · Hasselt and 1 other locations · NCT06785909

• Evaluating MRI for diagnosing low back pain in middle-aged women

  This study is testing how well MRI scans can help middle-aged women with low back pain find out what's causing their discomfort.

  Recruiting Sohag University · Sohag · NCT06766240

• Using a nerve block to relieve acute back pain in the emergency department

  This study is testing if a nerve block can help adults with acute low back pain in the emergency department feel better and recover faster compared to a placebo.

  Recruiting Rush University Medical Center · Chicago, Illinois · NCT06745453

• Effect of myofascial release on chronic low back pain in CrossFit practitioners

  This study is testing if myofascial release techniques can help CrossFit athletes with chronic low back pain feel better and improve their posture.

  Recruiting Universidade Federal de Goias · Goiânia, Goiás · NCT06715761

• Using the EXOPULSE Mollii Suit to treat low back pain

  This study is testing if wearing the EXOPULSE Mollii Suit can help people with chronic low back pain feel better compared to a fake version of the suit.

  Recruiting Institut De La Colonne Vertebrale Et Des Neurosciences · Créteil, VAL DE Marne · NCT06702189

• Using AI to analyze movement in patients with low back pain

  This study is testing how using AI to analyze movement can help understand why some people aged 18-65 with chronic low back pain have trouble moving and how to improve their treatment.

  Recruiting Pamukkale University · Denizli · NCT06686147

• Manual therapy for low back pain in postmenopausal women with osteopenia

  This study is testing if manual therapy can help relieve low back pain in postmenopausal women with osteopenia.

  Recruiting Cairo University · Giza · NCT06671665

• Evaluating the Role of Endogenous Opioids in Pain Relief from Spine Injections

  This study is testing how well lumbar spine injections relieve pain in people with low back pain and arthritis, while also seeing if the body's natural painkillers play a role in that relief.

  Recruiting Phase 4 Middle Tennessee Research Institute · Nashville, Tennessee · NCT06666621

• Examining the impact of Nociscan on back pain surgery outcomes

  This study is testing if a new software tool called Nociscan can help improve surgery results for people with low back pain by better identifying which discs are causing pain.

  Recruiting at 10 sites Aclarion · Phoenix, Arizona and 9 other locations · NCT06661850

• Lifestyle intervention for patients with persistent low back pain and obesity

  This study is testing a new lifestyle program for people with ongoing low back pain who are overweight to see if it can help them feel better and improve their daily lives.

  Recruiting VU University of Amsterdam · Amsterdam · NCT06594796

• Patient and therapist beliefs about spinal manipulation and physical therapy for low back pain

  This will see if patients' and their physical therapists' thoughts and beliefs change how much people with chronic low back pain improve from physical therapy that may include spinal manipulation, exercise, and education.

  Recruiting University of Florida · Gainesville, Florida · NCT06590116

• Comparing foot exercises and taping for low back pain linked to foot hyper-pronation

  This study is testing whether foot exercises or taping can help people with low back pain caused by flat feet feel better.

  Recruiting Riphah International University · Wāh, Punjab Province · NCT06584721

• Evaluating if pain modulation predicts improvement in chronic low back pain treatment

  This study is testing if a person's ability to manage pain can help predict how well they will respond to physical therapy for chronic low back pain.

  Recruiting Brooke Army Medical Center · Fort Sam Houston, Texas · NCT06544525

• Using Dronabinol to Help Reduce Chronic Low Back Pain

  This study is testing if a synthetic form of THC can help people with chronic low back pain feel better when used alongside their usual treatments.

  Recruiting Phase 2 Baylor College of Medicine · Houston, Texas · NCT06454669

• Telerehabilitation exercises versus standard home exercises for low back pain

  This tests whether a telerehabilitation program using camera-based AI feedback helps people with subacute or chronic nonspecific low back pain reduce disability and symptoms more than standard home exercise instructions.

  Recruiting University of Valencia · Valencia, Select One · NCT06446596

• Injections of Wharton's Jelly for treating low back pain

  This study is testing if injections made from umbilical cord tissue can help people with chronic low back pain feel better and improve their daily activities.

  Recruiting at 4 sites Phase 1 R3 Stem Cell · Scottsdale, Arizona and 3 other locations · NCT06361485

• Evaluating an interdisciplinary rehabilitation program for chronic low back pain

  This study is testing a new rehabilitation program to see if it helps adults with chronic low back pain feel better and improve their daily activities.

  Recruiting KU Leuven · Leuven · NCT06030570

• Evaluating caregiver transfer techniques for individuals with disabilities

  This study is testing how well caregivers help people with physical disabilities move and whether training can improve their techniques and reduce injuries.

  Recruiting VA Office of Research and Development · Pittsburgh, Pennsylvania · NCT06013878

• Examining back muscle characteristics to improve exercise therapy for low back pain

  This study is testing if understanding the differences in back muscles between people with low back pain and healthy individuals can help create better exercise programs to improve their posture and control.

  Recruiting at 2 sites Hasselt University · Diepenbeek and 1 other locations · NCT05851196

• A program to prevent low back pain recurrences through exercise and behavior change

  This study tests if a new exercise and behavior change program can help people with low back pain avoid future episodes better than regular care.

  Recruiting Instituto Politécnico de Setúbal · Setúbal, Setúbal District · NCT05841732

• Comparing health and motion in people with low back and neck pain to healthy individuals

  This study looks at how people with low back and neck pain move and feel compared to healthy individuals to see if we can learn more about their conditions and improve treatments.

  Recruiting Ohio State University · Columbus, Ohio · NCT05776771

• Understanding pain processing in adolescents with chronic pain conditions

  This study looks at how teenagers with ongoing pain conditions feel and process pain differently than those with specific pain or healthy teens to better understand what might cause their pain.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT05752396

• Comparing ibuprofen and dexamethasone for treating acute low back pain

  This study is testing if adding dexamethasone to ibuprofen can help people with acute low back pain feel better compared to just taking ibuprofen alone.

  Recruiting at 2 sites Phase 4 Montefiore Medical Center · The Bronx, New York and 1 other locations · NCT05721027

• Digital training programs for managing low back pain

  This study is testing two types of online exercise programs for people with low back pain to see if they help more than regular daily activity.

  Recruiting Vastra Gotaland Region · Vänersborg · NCT05679167

• Exploring how meditation affects pain relief in patients with chronic low back pain on opioids

  This study tests whether mindfulness meditation can help people with chronic low back pain who are taking opioids feel less pain.

  Recruiting University of Utah · La Jolla, California and 1 other locations · NCT05607381

• Epidural spinal cord stimulation for managing blood pressure and low back pain

  This study is testing if epidural spinal cord stimulation can help people with chronic low back pain and high blood pressure feel better by lowering their blood pressure and relieving their pain.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05556902

• Comparing Cognitive Functional Therapy and Pilates for Chronic Low Back Pain in the Elderly

  This study is testing whether Cognitive Functional Therapy delivered online is better than Pilates for helping older adults with chronic low back pain feel less pain and improve their daily life.

  Recruiting Centro Universitário Augusto Motta · Rio de Janeiro, Rio de Janeiro · NCT05480982

• Comparing dry needling and Tecartherapy for treating low back pain

  This study is testing whether dry needling or Tecartherapy is better at relieving chronic low back pain for people who suffer from it.

  Recruiting University of Alcala · Alcalá de Henares, Madrid · NCT05422040

• Impact of lumbar surgery on walking complexity in chronic low back pain patients

  This study is testing how lumbar surgery affects the walking ability of people with chronic low back pain to see if it helps them move better after the operation.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes and 1 other locations · NCT05231265

• Dry needling for chronic low back pain relief

  This study is testing if adding dry needling to regular physical therapy can help young adults with chronic low back pain feel better and improve their daily activities.

  Recruiting Iran University of Medical Sciences · Tehran, Tehran Province · NCT05100381

• Research on factors affecting low back pain recovery

  This study is trying to find out what helps or hinders recovery from low back pain by tracking people with both short-term and long-term pain over two years.

  Recruiting Laval University · Montreal, Quebec · NCT04791891

• Preventing neck and back pain in teleworking office workers

  This study is testing whether a training program and educational video can help office workers who work from home avoid neck and back pain over 12 weeks.

  Recruiting University Ghent · Ghent, East Flanders · NCT04783454

• Trigger point injections for low back pain relief

  This study is testing whether trigger point injections can help people with lower back pain feel better and improve their ability to move after visiting the Emergency Department.

  Recruiting Phase 4 Madigan Army Medical Center · Tacoma, Washington · NCT04704297

• Using patient history and physical exam to find sacroiliac joint dysfunction

  This project will test whether a short medical interview and targeted physical exam can help doctors spot sacroiliac joint–related low back or buttock pain in people with chronic symptoms.

  Recruiting University of Valencia · Valencia, Valencia · NCT04381208

• Investigating factors affecting pelvic girdle pain in pregnant women

  This study is trying to see how balance, body awareness, and mental health affect pelvic girdle pain in pregnant women who have had children before.

  Recruiting Hasselt University · Hasselt · NCT04226716

• Exploring how Qigong affects brain function and pain in people with chronic low back pain

  This study is testing whether practicing Qigong can help adults with chronic low back pain feel less pain and improve their awareness of their bodies compared to traditional exercise.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04164225

• Evaluation of a rehabilitation program for spine pain

  This study is testing a new rehabilitation program for people with spine pain to see if it helps them feel better and recover using both in-clinic and online methods.

  Recruiting SpineZone Medical Fitness, Inc · San Diego, California · NCT04081896

• Using lumbar braces in the emergency department for low back pain relief

  This study is testing whether using lumbar braces can help adults with low back pain in the emergency department feel better without relying on painkillers.

  Recruiting University of Alberta · Perth · NCT03829631

• Neck and low back pain among medical students at UWI Mona

  This project will test whether a standardised spine exercise program helps medical students at UWI Mona who have neck or low back pain while also measuring how common these pains are and students' spine-health knowledge.

  Recruiting The University of The West Indies · Kingston, Kingston and 1 other locations · NCT03707288

• Effect of integrated CAM treatment on hospitalized patients with musculoskeletal pain

  This study is testing whether a combined treatment of alternative therapies and regular medical care can help hospitalized patients with musculoskeletal pain feel better and improve their movement.

  Recruiting Jaseng Hospital of Korean Medicine · Seoul, Gangnam-Gu · NCT02257723

NIH-funded research (newest 40 of 102)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Ketamine-assisted care plan to help Veterans with chronic back pain and depression

  A program for Veterans with chronic low back pain and depression that uses ketamine infusions followed by a brief narrative therapy to sustain relief from pain and mood improvement.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11533116

• Savoring Meditation for Chronic Low Back Pain patients

  A study tests a brief mindfulness-based practice called Savoring Meditation to help people with chronic low back pain feel better emotionally and manage pain in daily life.

  NIH research University of Virginia · Charlottesville, United States · NIH-11465428

• Clinical Decision Support to Improve Low Back Pain Care

  A widely used digital tool helps doctors choose better, evidence-based care for people with low back pain in real clinics.

  NIH research Palmer College of Chiropractic · Davenport, United States · NIH-11448328

• Chronic Low Back Pain in Older Adults and Hip Impairments

  A study to help older adults with chronic low back pain, by looking at how hip problems affect their pain and function and testing tailored non-drug treatments.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11447991

• Mechanical signs from the spine’s discs that predict when back pain becomes long-lasting

  A Duke study aims to use new imaging and personal factors to see if the mechanical health of spinal discs can predict when acute low back pain becomes chronic.

  NIH research Duke University · Durham, United States · NIH-11446556

• Genetic predictors of recovery and surgical outcomes for Veterans with chronic low back pain and lumbosacral spine disorders

  This project uses VA health records and genetic information to find DNA markers linked to how Veterans fare with chronic low back pain and related spine conditions.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11446450

• Whole-person approach to chronic low back pain with advanced phenotyping

  A large NIH project from the University of Pittsburgh aims to map and understand chronic low back pain through deep, real-world data on biology, behavior, and function to help tailor future treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419847

• Personalized multicomponent therapy for chronic low back pain using smart patient-based algorithms

  A U-Michigan-led effort tests a personalized approach to chronic low back pain by tailoring several treatments to individual patients using smart, data-driven decision rules.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11418354

• Epigenetic drivers of chronic low back pain

  A patient-friendly look at how DNA methylation might influence disc-related back pain and potential new ways to treat it beyond opioids.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11418084

• What causes back pain flares and how to prevent them

  A back-pain study in Australia will use recent tech to see what triggers flare-ups in people with acute to chronic low back pain.

  NIH research University of Queensland · Brisbane, Australia · NIH-11417863

• Deep Brain Stimulation for Chronic Low Back Pain

  A new brain-targeted therapy is tested to help people with long-standing, hard-to-treat low back pain that hasn’t improved with other treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11417113

• Improving back-pain care in rural areas with tele-physical therapy

  This project tests a tele-rehabilitation program to help adults with chronic low back pain in rural communities access physical therapy and reduce opioid use.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11412950

• Biomarkers that reveal why acute low back pain becomes chronic

  A study on blood signals and immune factors in people with new acute low back pain to find clues that predict who will develop chronic pain.

  NIH research Duke University · Durham, United States · NIH-11412948

• A Better Way to Help People with Low Back Pain Using Radiofrequency Nerve Treatment

  A large NIH-supported study tests whether a targeted nerve-dulling procedure (radiofrequency ablation) can reliably help people with chronic low back pain who meet specific diagnostic criteria.

  NIH research University of Washington · Seattle, United States · NIH-11401715

• Mechanistic insights into chronic low back pain using patient tissues

  Researchers are studying nerve and tissue changes in people with chronic low back pain who are having spine surgery to find new clues that could lead to better treatments.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11399406

• Spine-hip exoskeletons with smart control to ease lower back pain

  A team is testing a spine-hip soft exoskeleton with learning-based control to reduce strain and injury risk for workers who lift heavy loads.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11394296

• Interprofessional Outpatient Therapy for Native Americans with Low Back Pain

  A collaborative outpatient program using physical and occupational therapy to help Cherokee Nation members manage low back pain without relying on drugs or surgery.

  NIH research Cherokee Nation · Tahlequah, United States · NIH-11369411

• Psilocybin for Chronic Back Pain: Brain Signals and Real-World Therapy Outcomes

  A patient-facing study will test whether a carefully controlled psilocybin treatment can improve body awareness and enhance physical therapy outcomes for people with chronic low back pain.

  NIH research Yale University · New Haven, United States · NIH-11359203

• Increase use of non-drug therapies for chronic low back pain

  A study to help people with chronic low back pain use proven non-pharmacological therapies more often, by empowering patients to advocate for these treatments in their networks.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11358692

• Cannabis Coaching for Chronic Low Back Pain: A Multi-Site Feasibility Study

  A multi-site study tests a cannabis-coaching program designed to help people with chronic low back pain use legal cannabis products safely and effectively.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11358127

• Mindfulness-based brain science to reduce pain and opioid use in chronic back pain

  A study at UC San Diego tests how Mindfulness-Oriented Recovery Enhancement may help people with chronic low back pain use fewer opioids by changing brain activity.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11348866

• Understanding what causes disc-related back pain and how to treat it

  This grant explores how nerve growth, inflammation, and mechanical stress in the spinal disc contribute to chronic discogenic low back pain and whether targeting these factors can relieve pain.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11346026

• An adaptive plan to help pain after CBT for insomnia in people with chronic back pain

  A patient-facing program will test a supplemental, hopeful approach added to standard CBT for insomnia to see if it can reduce pain for people who have chronic low back pain and insomnia.

  NIH research University of Virginia · Charlottesville, United States · NIH-11332862

• Auricular stimulation for chronic low back pain: brain changes measured with noninvasive imaging

  A noninvasive study tests whether ear-based stimulation changes brain activity and connectivity in healthy volunteers and people with chronic low back pain.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11325702

• Virtual reality program to reduce chronic low back pain

  This project will see if a virtual-reality, brain-targeting treatment can reduce long-term low back pain in adults.

  NIH research Cognifisense, INC. · Sunnyvale, United States · NIH-11322088

• Acupuncture for Medicare Beneficiaries with Chronic Low Back Pain

  This project looks at how coverage of acupuncture for chronic low back pain in Medicare beneficiaries affects outcomes, access, and costs.

  NIH research Southern California Univ of Health Scis · Whittier, United States · NIH-11311347

• How fat builds up in back muscles with chronic low back pain

  Researchers will use advanced MRI plus movement and muscle tests to link patterns of fat in back muscles to symptoms in people with chronic low back pain.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11306684

• Spinal movement problems and early low back pain recovery

  This project looks at whether certain spine movement problems in adults with new low back pain affect how quickly and how well they recover, and whether treating those problems helps.

  NIH research Washington University · Saint Louis, United States · NIH-11296839

• Brain changes in chronic low back pain across ages and sexes

  This project looks for brain-based markers of long-term low back pain and how aging and biological sex change those brain patterns for people with chronic low back pain.

  NIH research University of Rochester · Rochester, United States · NIH-11295443

• Understanding how the immune system affects chronic back pain

  A research study is exploring how immune system signals and antibodies contribute to low back pain and how this could lead to better treatments for people with persistent back pain.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11268384

• How race and income affect long‑term low back pain

  This project looks at why adults of different races and socioeconomic backgrounds, especially Black and White adults, experience different levels of long‑lasting low back pain.

  NIH research Washington University · Saint Louis, United States · NIH-11251322

• Two neurosteroid medicines being tested for chronic low back pain in U.S. veterans

  This project will compare two experimental neurosteroid medicines against a placebo to see if they safely ease chronic low back pain in U.S. military veterans.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11249118

• Understanding the causes of low back pain related to disc degeneration

  This study is looking into how issues with your back discs can cause ongoing pain, focusing on how stress and inflammation affect nerves in those discs, with the hope of finding new ways to help relieve that pain.

  NIH research Arizona State University-Tempe Campus · Tempe, United States · NIH-11247718

• UCSF REACH: smarter understanding of chronic low back pain using big data and models

  A big NIH grant will help UCSF build and test a data-driven model to understand chronic low back pain and guide better care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11211838

• Facet-driven low back pain: a targeted look at why pain varies between people

  A large study focuses on people with facet-mediated persistent low back pain to understand why pain levels differ and how treatments work for different patients.

  NIH research University of Washington · Seattle, United States · NIH-11206071

• A lab model of chronic disc-related low back pain

  Researchers are reproducing a rat model that mimics long-lasting disc-related low back pain to better reflect the symptoms people experience.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11195581

• Remote physical therapy to ease chronic low back pain and cut opioid use in rural communities

  This project offers remote physical therapy to people with long-term low back pain in rural areas to help them move better and depend less on opioid pain medicines.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11194520

• What makes low back pain flare up?

  Researchers will look for short-term triggers of flare-ups in people who have ongoing or recurring low back pain.

  NIH research University of Queensland · Brisbane, Australia · NIH-11192342

• Radiofrequency nerve heating for chronic low back pain

  This compares a specific lumbar radiofrequency ablation approach to provide better pain relief for people with chronic low back pain linked to the facet joints.

  NIH research University of Washington · Seattle, United States · NIH-11182523

• DNA methylation and chronic low back pain

  This project looks at how DNA on/off switches (DNA methylation) change in people with long-term low back pain to find new ways to treat disc-related pain.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11181647

Related topics

Quick answers

How many Low Back Pain clinical trials are recruiting right now?

117, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 30 countries. The most sites are in United States (29 trials), Pakistan (17 trials), Turkey (Türkiye) (11 trials), France (7 trials), Egypt (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 2: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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