Metabolomic biomarker profiles for osteoarthritis
Official title: Metabolomic Profiling to Identify Candidate Biomarker Profiles and Molecular Endotypes for Osteoarthritis
Funded at Montana State University - Bozeman · NIH-11381970 · Data updated 2026-11-12
A research project at Montana State University looks for metabolite patterns in blood and joint fluid that could signal early osteoarthritis before symptoms become severe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $418,609 |
| NIH project number | 5R01AR081489-04 |
| Project ID | NIH-11381970 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults at risk for OA or with early signs of joint pain who may provide blood and, when available, synovial fluid samples.
✕Less likely to help
Individuals without OA risk or early disease markers may not gain direct benefits from these biomarker discoveries.
What this research studies
This project uses metabolomic profiling to search for biomarker patterns in blood plasma and synovial fluid that reflect early osteoarthritis. By analyzing small molecules produced by joint cells, researchers hope to identify a panel that could indicate disease before it progresses. The goal is to create biomarkers that clinicians can use to detect OA early and guide treatment decisions. The work combines advanced lab analysis with patient-relevant outcomes to move toward earlier and more precise care for OA.
Why it matters
Potential benefit: If successful, patients could get earlier diagnosis and more targeted interventions to slow or prevent OA progression.
How similar studies have gone: Previous OA biomarker studies have identified candidate markers, but none are FDA-approved, making this an area of ongoing development.
Where this research is happening
-
Montana State University - Bozeman
Bozeman, United States Active
Researchers
- Principal investigator: June, Ronald Kent — Montana State University - Bozeman
- Study coordinator: June, Ronald Kent
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.