Analyzing cell therapies for osteoarthritis using donated tissues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the cartilage and bone forming potential of cells obtained from tissues of patients undergoing surgeries for polydactyly and hip dislocation. Participants will donate waste tissue from digit amputations and small cartilage samples from the iliac apophysis during hip surgeries. The study will compare the effectiveness of these tissues in producing cartilage both in vitro and in vivo. The research is part of a broader effort to develop innovative cell-based therapies for osteoarthritis and related conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For juvenile/infant donors:

* Parents/guardians being able to provide signed and dated informed consent form.
* Scheduled for one of the following surgical treatments:

Digit amputations due to polydactyly. Surgery to treat dislocated hips.

For biobank/NHSBT donors

* Informed consent via consenting institution.

Exclusion Criteria:

* Parents/guardians not understanding the Patient Information Sheet

Where it's running

• Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
  Oswestry, Shropshrie, United Kingdom Recruiting

Study contacts

• Principal investigator: Karina T Wright, PhD — ISTM, Keele University
• Study coordinator: Karina T Wright, PhD
• Email: karina.wright1@nhs.net
• Phone: +441691404022

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.