Analyzing cell therapies for osteoarthritis using donated tissues
Investigating the Potential for Musculoskeletal Tissues and Cells Isolated From Juvenile Patients in the Development of Novel Therapies for Cartilage and Bone Injury and Osteoarthritis
Keele University · NCT06167928
This study is testing whether cells from donated tissues of patients with polydactyly and hip dislocation can help create new cartilage for people with osteoarthritis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 325 (estimated) |
| Sex | All |
| Sponsor | Keele University (other) |
| Locations | 1 site (Oswestry, Shropshrie) |
| Trial ID | NCT06167928 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the cartilage and bone forming potential of cells obtained from tissues of patients undergoing surgeries for polydactyly and hip dislocation. Participants will donate waste tissue from digit amputations and small cartilage samples from the iliac apophysis during hip surgeries. The study will compare the effectiveness of these tissues in producing cartilage both in vitro and in vivo. The research is part of a broader effort to develop innovative cell-based therapies for osteoarthritis and related conditions.
Who should consider this trial
Good fit: Ideal candidates include infants and juveniles scheduled for digit amputations due to polydactyly or surgeries for dislocated hips.
Not a fit: Patients who do not require surgery or are unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cell therapies for osteoarthritis, enhancing patient outcomes and quality of life.
How similar studies have performed: While there have been successful studies using autologous chondrocyte implantation, this approach using allogeneic tissues is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For juvenile/infant donors: * Parents/guardians being able to provide signed and dated informed consent form. * Scheduled for one of the following surgical treatments: Digit amputations due to polydactyly. Surgery to treat dislocated hips. For biobank/NHSBT donors * Informed consent via consenting institution. Exclusion Criteria: * Parents/guardians not understanding the Patient Information Sheet
Where this trial is running
Oswestry, Shropshrie
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust — Oswestry, Shropshrie, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Karina T Wright, PhD — ISTM, Keele University
- Study coordinator: Karina T Wright, PhD
- Email: karina.wright1@nhs.net
- Phone: +441691404022
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Osteoarthritis, Cell therapy, Musculoskeletal, Allogeneic