Understanding hip osteoarthritis risk from hip shapes and genetics
Official title: Redefining the Lifelong Natural History of Hip Osteoarthritis in Patients with Morphologic Abnormalities
Funded at Mayo Clinic Rochester · NIH-11424533 · Data updated 2026-11-12
Researchers will look at how the shape of the hip and genetics influence the chances of developing hip OA and needing joint replacement, using AI to study large patient data.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $607,990 |
| NIH project number | 1R01AR088008-01 |
| Project ID | NIH-11424533 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with known hip morphology variations and available genetic and radiographic data.
✕Less likely to help
People without hip morphology concerns or without access to imaging/genetic data may not directly benefit.
What this research studies
This grant aims to connect hip bone shape and genetics to the course of hip OA over time. It uses whole-exome sequencing and deep learning on radiographs to explore how morphology affects OA progression. Advanced AI methods will fill gaps in imaging data to study big groups and identify patterns that precede OA or arthroplasty. The work may guide earlier detection and prevention strategies for people with hip morphology changes.
Why it matters
Potential benefit: If successful, the findings could lead to earlier identification of people at risk for hip OA and inform targeted prevention or treatment strategies.
How similar studies have gone: Prior studies have linked hip morphology and genetics to OA risk, but this project aims to enhance prediction with AI.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Wyles, Cody C — Mayo Clinic Rochester
- Study coordinator: Wyles, Cody C
Related research
Other NIH-funded projects on the same topics.
-
DNMT3A as a Target to Protect Hip Joints in Osteoarthritis
A patient-friendly study aims to see if turning down a specific gene pathway can slow cartilage damage in people with femoroacetabular impingement and early hip OA.
-
Bone-anchored (osseointegrated) prostheses and hip arthritis after above-knee amputation
This project compares bone-anchored (osseointegrated) prostheses with traditional socket prostheses to understand their effects on hip arthritis in people with transfemoral (above-knee) amputations.
-
Impact of bone-anchored prostheses on hip arthritis in amputees
This study is looking at how different types of leg prosthetics, one that connects directly to the bone and another that uses a socket, might affect the health of your hip joint if you've lost a leg, to help find better options for amputees.
-
Understanding how hip muscle problems affect exercise in people with hip osteoarthritis
This study is looking at how problems with hip muscles affect exercise for people with hip osteoarthritis, so we can help create better workout plans that make it easier for you to stay active and feel better.
-
Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.
-
Identifying OA subtypes and early warning signs before joint damage
This grant asks researchers to find early, invisible clues of osteoarthritis subtypes so we can target treatments before joints are damaged.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.