Herbal combination (Boswellia, turmeric, grape extract) for hip or knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, placebo-controlled crossover trial in which adults with clinically diagnosed hip or knee osteoarthritis will take the active herbal supplement for four weeks and a matching placebo for four weeks, one after the other. Participants will complete validated symptom questionnaires and three performance-based physical tests six times in total and will provide a urine sample for safety or compliance checks. Eligible participants must have moderate pain (NRS ≥4) and functional impairment (Lequesne Index ≥7); people with autoimmune disease, recent steroid injections, severe joint damage, pregnancy, or abnormal liver/kidney function are excluded. The primary comparison is symptom change between the supplement and placebo periods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥ 18
* Diagnosis of osteoarthritis in knee or hip
* Numerical Rating Scale (NRS) ≥ 4 during the most painful movement in the last 24 hours
* Lequesne's Functional Index (LFI) score ≥ 7
* Ambulant patient

Exclusion Criteria:

* Pregnant and breastfeeding
* Autoimmune disease such as rheumatoid arthritis, gout, lupus
* Joint trauma, joint injury, joint infection, meniscus tear, complete loss of articular cartilage
* Expectation of surgery
* History of the viscous or corticosteroids injections into affected joints or oral corticosteroids within last 12 months
* Allergy to one of the intervention's ingredients or NSAIDs
* Peptic ulceration and upper gastrointestinal haemorrhage
* High alcohol intake, inability to abstain from alcohol, substance abuse, history of addiction
* Tumor, cancer
* Abnormal renal or/and hepatic functions or altered blood chemistry
* Use of concomitant medication able to interfere with the interventions

Where it's running

• Middlesex Univeristy London
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Patrycja Brodka Pedrp, MSc
• Email: p.x.brodkapedro@mdx.ac.uk
• Phone: 020-8411-2721

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.