Condition

Sarcoidosis clinical trials and research

• 23Clinical trials
• 33NIH research projects
• 11Countries

Newest Sarcoidosis clinical trials

All recruiting trials (23)

• Two prednisolone tapering plans for people with stable sarcoidosis

  The team will try two different prednisolone tapering plans to see if people with stable sarcoidosis taking 5–10 mg/day can safely cut their dose by at least half.

  Recruiting Royal Brompton & Harefield NHS Foundation Trust · London · NCT07498842

• Immune cells in lung disease and how they could guide immunotherapy

  This project sees if immune cell profiling from blood can explain why people with lung cancer, sarcoidosis, or COPD respond differently to immunotherapy or develop chronic lung inflammation.

  Recruiting Université Catholique de Louvain · Brussels · NCT07384897

• Imaging in Inflammatory Heart Diseases linked to autoimmune disorders

  This study tests how well multimodality imaging (CMR, echocardiography, and PET) detects inflammation in people with suspected inflammatory heart or autoimmune rheumatic diseases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07077304

• Virtual groups to reduce sarcoidosis-related fatigue

  This project tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can help reduce fatigue and improve anxiety and depression in adults with sarcoidosis compared with a monthly virtual support group.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07073963

• Counting and classifying inflammatory cells in uveitis with OCT

  This project will try to use high-resolution OCT scans to count and categorize inflammatory cells and proteins in people with anterior uveitis and related eye inflammation.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT07065747

• Comparing yoga and physiotherapy for sarcoidosis treatment

  This study is testing whether yoga or traditional physiotherapy helps people with sarcoidosis improve their lung function and feel better overall.

  Recruiting Saglik Bilimleri Universitesi · Istanbul, Maltepe · NCT06848608

• Investigating the Role of Y Chromosome Mutations in Autoimmune Diseases

  This study is trying to see how changes in the Y chromosome might affect the immune system and contribute to autoimmune diseases like Giant Cell Arteritis and Polymyalgia Rheumatica.

  Recruiting University of Bonn · Bonn, North Rhine-Westphalia · NCT06696027

• Study of heart conditions using advanced imaging techniques

  This study is trying to find out what causes different heart conditions in Hispanic and African American people in the Bronx by using advanced imaging techniques.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT06610019

• Understanding immune responses in sarcoidosis

  This study is trying to understand how the immune system works in people with sarcoidosis to see if it can help create better, personalized treatments for them.

  Recruiting Region Stockholm · Stockholm, Stockholm County · NCT06576505

• Registry for Rare Diseases

  This study is creating a detailed registry to collect information on rare diseases like amyloidosis and sarcoidosis to help improve how they are diagnosed and treated.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires · NCT06573723

• Cryobiopsy for diagnosing mediastinal conditions in Sweden

  This study is testing a new biopsy method to see if it helps doctors better diagnose lung and chest conditions like cancer and infections in patients.

  Recruiting at 2 sites Region Skane · Lund and 1 other locations · NCT06347939

• Registry for people living with sarcoidosis

  This study is collecting health information from people with sarcoidosis to better understand the condition and help future research.

  Recruiting Foundation for Sarcoidosis Research · Chicago, Illinois · NCT06234384

• Understanding immune cell behavior in sarcoidosis and tuberculosis

  This study is trying to understand how certain immune cells behave in people with sarcoidosis and tuberculosis to see what causes the ongoing inflammation in these conditions.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05916638

• Investigating immune cells in sarcoidosis patients

  This study is trying to learn more about immune cells in people with sarcoidosis to understand why some patients have ongoing symptoms while others get better on their own.

  Recruiting Region Stockholm · Stockholm · NCT05751447

• Biobank for interstitial lung diseases

  This study is setting up a collection of health information and samples from patients with interstitial lung diseases to help researchers learn more about the condition and find better treatments.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT05392881

• Using advanced imaging to evaluate small lung biopsy samples

  This study is testing a new imaging method to see if it can improve the quality of small lung biopsy samples taken during bronchoscopy for patients being checked for lung cancer or sarcoidosis.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05171478

• Registry and biorepository for rheumatic diseases

  This study is collecting samples and health information from adults with rheumatic diseases at Yale clinics to help researchers learn more about these conditions and improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT04402086

• Investigating cell-free DNA in cardiac sarcoidosis

  This study is testing if cell-free DNA can help doctors detect active heart inflammation in people with sarcoidosis.

  Recruiting University of Iowa · Iowa City, Iowa and 1 other locations · NCT03858777

• Evaluating vitamin D's role in sarcoidosis

  This study is testing if giving vitamin D to people with sarcoidosis who have low levels of it can help reduce their symptoms compared to those who get a placebo.

  Recruiting Phase 4 University of Texas Southwestern Medical Center · Dallas, Texas · NCT03621553

• Comparing low dose Prednisone and Methotrexate to standard dose Prednisone for cardiac sarcoidosis

  This study is testing whether a low dose of Prednisone combined with Methotrexate can help people with cardiac sarcoidosis just as well as a standard dose of Prednisone, while also making them feel better and reducing side effects.

  Recruiting at 26 sites Phase 3 Ottawa Heart Institute Research Corporation · New Haven, Connecticut and 30 other locations · NCT03593759

• Registry and biobank for arrhythmogenic ventricular cardiomyopathy

  This study is trying to gather information and samples from people with arrhythmogenic ventricular cardiomyopathy and their families to better understand the genetic causes of the condition and improve early diagnosis for those at risk.

  Recruiting at 2 sites Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT03049254

• Using cardiac MRI to detect heart issues in sarcoidosis patients

  This study is testing if a special heart scan can help find hidden heart problems in people with sarcoidosis that might be affecting their health.

  Recruiting Duke University · Durham, North Carolina · NCT01745237

• Observing the natural progression of interstitial lung disease

  This study is collecting data and blood samples from people with interstitial lung disease to see how the condition progresses over time and to better understand its effects.

  Recruiting University of Chicago · Chicago, Illinois · NCT00470327

NIH-funded research (33)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrative metabolomics to improve sarcoidosis diagnosis and prognosis

  A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11496248

• Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism

  Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11451047

• Understanding how inflammation and scarring develop in pulmonary sarcoidosis

  A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11419620

• Peptide-based Diagnostic Test for Sarcoidosis

  A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.

  NIH research Kephera Diagnostics, LLC · Framingham, UNITED STATES · NIH-11417199

• Molecular markers of progressive pulmonary sarcoidosis

  This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.

  NIH research National Jewish Health · Denver, United States · NIH-11396447

• Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis

  A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11392382

• Understanding why sarcoidosis happens and how it affects people using multi-omics

  A multi-omics study aims to uncover why sarcoidosis affects people differently and to find biomarkers that predict disease burden.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11387839

• Predicting future lung health in sarcoidosis

  This project is building tools to predict which people with pulmonary sarcoidosis will have meaningful drops in lung function using routine clinic data and new blood markers.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11378898

• Precision PET attenuation correction for heart PET/MR imaging

  Aimed at improving PET/MR heart imaging by perfecting how PET signals are corrected for tissue, so patients get accurate results in one combined test instead of separate scans.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11378430

• CXCR3 Blockade as a Targeted Therapy for Cardiac Sarcoidosis

  A study to see if blocking CXCR3 can help treat heart involvement in sarcoidosis patients using advanced immune profiling and a mouse model.

  NIH research Stanford University · Stanford, United States · NIH-11372257

• Understanding why sarcoidosis causes immune confusion and damage

  Researchers are studying why sarcoidosis triggers a stubborn immune response, with a focus on how immune cells in the lungs and lymph nodes interact and why some patients develop worse, fibrotic disease.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11302507

• Role of BHLHE40 in CD8 T Cells and Lung Sarcoidosis

  Aims to understand how a specific immune cell type (CD8 T cells) controls lung inflammation and scarring in sarcoidosis patients.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11296236

• Understanding Pulmonary Sarcoidosis with Protein Signatures

  This project aims to find unique protein patterns in people with pulmonary sarcoidosis to help doctors better understand and treat the disease.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11293906

• Finding new ways to diagnose and predict sarcoidosis

  This project aims to discover tiny genetic markers called microRNAs that can help doctors better diagnose sarcoidosis and understand how it might progress.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11271363

• Residential bioaerosol exposure and lung disease in sarcoidosis

  A patient-facing study exploring how the air inside homes might affect lung health for people with sarcoidosis.

  NIH research University of Iowa · Iowa City, United States · NIH-11271247

• Molecular clues behind progressive lung sarcoidosis

  This project looks at proteins and genes in blood and lab granuloma models to find early signs that someone with sarcoidosis will develop worsening lung disease.

  NIH research National Jewish Health · Denver, United States · NIH-11173880

• Investigating how exposure to residential bioaerosols affects lung health in sarcoidosis patients

  This study is looking at how tiny particles in the air at home might affect people with pulmonary sarcoidosis, helping us understand if these particles could make their lung condition worse.

  NIH research University of Iowa · Iowa City, United States · NIH-11160190

• Immune cell patterns in sarcoidosis

  The project uses gene and protein tests on immune cells to find markers that could help diagnose sarcoidosis and predict how it will behave.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11143841

• MRI and PET scans to track treatment response in active cardiac sarcoidosis

  This project uses PET and MRI scans with advanced imaging measures and AI to monitor how people with active cardiac sarcoidosis respond to immune-suppressing treatments.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11141926

• Understanding how certain hormones affect granulomas in sarcoidosis

  This study is looking at how certain hormones might affect immune cells in people with sarcoidosis, a condition that causes inflammation, to find new ways to treat the disease and improve care for patients.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11129915

• Using microRNAs to improve diagnosis and prognosis in sarcoidosis

  This study is looking for tiny molecules in your lung fluid that could help doctors better diagnose and understand sarcoidosis, and if you choose to participate, your samples could help improve care for everyone with this condition.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11124898

• Predicting Lung Changes in Sarcoidosis

  This project aims to create new tools that help doctors understand how lung sarcoidosis might progress for individual patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11078189

• Improving care for Black patients with sarcoidosis

  This study is working to create a program that helps Black individuals with sarcoidosis by listening to their experiences and finding ways to improve their care and support.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11061398

• Understanding how metabolites can help diagnose and track sarcoidosis

  This study is looking at how analyzing certain chemicals in the blood can help doctors better diagnose and track sarcoidosis, especially in African American women who may face more challenges with the disease, so that patients can get the care they need more quickly and accurately.

  NIH research National Jewish Health · Denver, United States · NIH-11049526

• Improving care and understanding of sarcoidosis through collaboration

  This study is all about a conference where experts from different fields come together to share ideas on how to improve care for people with sarcoidosis, so that patients can benefit from better treatments and understanding of their condition.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11000433

• Investigating imaging responses to immune suppressant therapy in cardiac sarcoidosis patients

  This study is looking at how well certain imaging tests can show if patients with cardiac sarcoidosis are responding to their immune-suppressing treatments, with the goal of finding better ways to help them feel better.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10999907

• Understanding immune cells in sarcoidosis

  This study is looking at how the immune system works in people with sarcoidosis to find helpful clues for diagnosing and tracking the disease, especially focusing on those of African ancestry.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-10954075

• Understanding the molecular features of progressive pulmonary sarcoidosis

  This study is looking at the unique proteins and genes in people with sarcoidosis to help find out who might be at risk for their lung condition getting worse, so we can create better ways to predict and manage the disease.

  NIH research National Jewish Health · Denver, United States · NIH-10912435

• Identifying molecular markers for pulmonary sarcoidosis

  This study is looking to find ways to tell if pulmonary sarcoidosis will get worse or stay the same by checking proteins in blood and lung samples, which could help doctors give you the best treatment possible.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10907457

• Investigating immune cells and proteins to understand sarcoidosis severity

  This study is looking at how certain immune cells and proteins in your blood relate to the severity of sarcoidosis and how well your lungs are working, so we can better understand the disease and improve treatment for patients like you.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10897084

• Understanding how medication adherence affects health in sarcoidosis patients

  This study is looking at how well people with sarcoidosis, especially in the African American community, stick to their medication and how that affects their health, with the goal of finding ways to help them manage their treatment better and improve their quality of life.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10888354

• Understanding the immune response in sarcoidosis and the effects of a specific treatment

  This study is looking at how a new type of medicine called JAK inhibitors might help treat sarcoidosis, especially for African Americans who haven't had success with other treatments, by examining skin and blood samples to learn more about the immune system's role in the disease.

  NIH research Yale University · New Haven, United States · NIH-10877021

• Investigating how a hormone system affects granuloma formation in sarcoidosis

  This study is looking at how a system in your body called RAAS affects the growth of granulomas in sarcoidosis, and it hopes to find new ways to help people with this condition by testing if blocking certain parts of this system can reduce granuloma formation.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10744243

Related topics

Quick answers

How many Sarcoidosis clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (13 trials), Sweden (3 trials), United Kingdom (3 trials), France (2 trials), Argentina (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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