Condition

Tuberculosis clinical trials and research

• 64Clinical trials
• 522NIH research projects
• 2New in 30 days
• 40Countries

Newest Tuberculosis clinical trials

All recruiting trials (64)

• Biomarker Test for Diagnosis and Monitoring of Extrapulmonary Tuberculosis

  This study tests biomarker-based methods to help diagnose extrapulmonary TB and monitor treatment in adults, including people living with HIV, using samples from affected sites in Kenya.

  Recruiting at 2 sites Nagasaki University · Nairobi and 1 other locations · NCT07901387

• Short-Course TB Treatment for Children with Non-Severe Pulmonary TB

  This trial tests two shorter-treatment options for kids with non-severe pulmonary TB to see if they can clear the infection as well as the standard 6-month plan.

  Recruiting at 13 sites Phase 2 Huashan Hospital · Fuzhou, Fujian and 12 other locations · NCT07893444

• Combined oral contraceptive timing with Ganfeborole in healthy women

  This study tests how the contraceptive Microgynon behaves in the body when given alone and with Ganfeborole in healthy women who can’t get pregnant.

  Recruiting Phase 1 GlaxoSmithKline · Madrid · NCT07784894

• Isoniazid inhalation in TB patients: a first-in-human look at local tolerability and body levels

  This early study tests inhaled isoniazid to see how well it tolerates the lungs and how it behaves in the body in adults with tuberculosis.

  Recruiting Phase 1 University Medical Center Groningen · Groningen · NCT07708779

• How the immune system responds to mycobacterial infections

  This study tests how the immune system changes in people with tuberculosis and related mycobacterial infections.

  Recruiting First Affiliated Hospital of Ningbo University · Ningbo · NCT07638670

• Active breathing plus balloon-blowing for children with tuberculosis

  This trial will test whether adding balloon-blowing exercises to the Active Cycle of Breathing Technique helps children aged 8–14 with tuberculosis clear sputum, reduce breathlessness, and walk farther.

  Recruiting Riphah International University · Lahore · NCT07484490

• Reexamining how asymptomatic tuberculosis spreads

  This project will test whether people with asymptomatic tuberculosis—particularly adults living with HIV—can pass TB to their household and close contacts.

  Recruiting Barcelona Institute for Global Health · Manhiça, Maputo Province · NCT07312266

• New TB Diagnostics for Indonesia: Non-sputum Tests at Health Facilities

  This trial tests a package of near point-of-care TB tests and related care changes to see if TB notifications rise in Indonesian health facilities.

  Recruiting Universitas Padjadjaran · Bandung, West Java · NCT07293455

• JDB0131 tablets for drug-resistant pulmonary TB

  This tests two doses of the experimental tablet JDB0131 versus a delamanid-containing regimen in people aged 14–65 with rifampicin-resistant or multidrug-resistant pulmonary tuberculosis over an 8-week treatment period.

  Recruiting at 6 sites Phase 2 WestVac Biopharma Co., Ltd. · Wuhan, Hubei and 6 other locations · NCT07170800

• Measuring TB DNA in blood and urine

  This test checks whether measuring Mycobacterium tuberculosis cell-free DNA in blood and urine can detect active TB in hospitalized patients and distinguish them from people with latent TB or no infection.

  Recruiting Chinese University of Hong Kong · Hong Kong, Hong Kong and 1 other locations · NCT07170735

• EEC skin test to diagnose tuberculosis infection in people aged 3 and older

  This test checks whether the EEC skin test can accurately detect TB infection in people aged 3 and older, compared with existing skin tests and a blood IGRA.

  Recruiting at 7 sites Phase 3 Chengdu CoenBiotech Co., Ltd · Beijing, Beijing Municipality and 7 other locations · NCT07152639

• Sputum-free diagnosis of tuberculosis

  This study will test whether blood, urine, or stool samples can diagnose tuberculosis in adults suspected of TB, including people who cannot produce sputum.

  Recruiting Research Center Borstel · Hamburg · NCT07125274

• Daily rifapentine and isoniazid for TB prevention in children under 13, with and without HIV

  This study tests a 28-day daily course of rifapentine plus isoniazid to prevent tuberculosis in children under 13, including kids with HIV who are on antiretroviral therapy.

  Recruiting at 5 sites Phase 1/2 National Institute of Allergy and Infectious Diseases (NIAID) · Gaborone and 10 other locations · NCT07124559

• Omega-3 supplements added to standard TB treatment in adults with pulmonary TB

  This trial tests whether adding omega-3 EPA and DHA to standard TB therapy for 8 weeks helps kill the bacteria faster and reduce inflammation in adults with new, drug-sensitive pulmonary TB.

  Recruiting Phase 2 North-West University, South Africa · Klerksdorp, North West · NCT07118059

• Coach Mpilo peer support for men with TB and HIV

  We will test whether Coach Mpilo, a peer-support program developed by men, helps men starting TB treatment — including those with HIV — complete TB therapy and achieve better HIV viral suppression.

  Recruiting Arizona State University · East London · NCT07117370

• Window-period preventive treatment to prevent TB infection in children and adolescents.

  This trial will try weekly isoniazid plus rifapentine for 12 weeks to see if it prevents TB infection in household contacts aged 5 to 17 years who are IGRA-negative after recent exposure.

  Recruiting at 5 sites Pontificia Universidad Catolica de Chile · Calama, Antofagasta and 12 other locations · NCT07086820

• C3PO: Predicting tuberculosis recurrence with blood and sputum tests

  This project will test whether new blood and sputum-based tests can identify people who are likely to get tuberculosis again after finishing standard treatment.

  Recruiting at 2 sites University of California, San Francisco · Kampala and 2 other locations · NCT07018076

• Long-term effects of tuberculosis on lung health in Korea

  This study is trying to see how tuberculosis affects lung health and quality of life over time in adults who are being treated for or have had TB in Korea.

  Recruiting Yonsei University · Seoul · NCT06946784

• Tuberculosis treatment pathways and outcomes in France: a national cohort

  This French national cohort follows adults starting tuberculosis treatment to see how sociodemographic, clinical, and biological factors relate to treatment outcomes and relapse over 24 months.

  Recruiting ANRS, Emerging Infectious Diseases · Paris and 1 other locations · NCT06893757

• Improving diagnosis and treatment monitoring for children with tuberculosis

  This study is testing new ways to diagnose and track treatment for tuberculosis in children by using different samples and checking their lung health and quality of life.

  Recruiting Research Center Borstel · Bucharest, BUC · NCT06815588

• Evaluating the safety and effects of alpibectir with ethionamide for tuberculosis treatment

  This study is testing whether a new drug called alpibectir, when combined with ethionamide, is safe and effective for treating people with pulmonary tuberculosis.

  Recruiting Phase 2 TASK Applied Science · Cape Town, Western Cape · NCT06748937

• Screening for tuberculosis in high-risk groups in Barcelona

  This study is trying to find and test people in high-risk groups in Barcelona for tuberculosis to help catch and treat the disease early.

  Recruiting Fundació Institut Germans Trias i Pujol · Badalona · NCT06706596

• Testing a new tuberculosis vaccine with a BCG challenge

  This study is testing a new tuberculosis vaccine to see if it is safe and effective in people who have and haven't had the BCG vaccine before.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT06670755

• Validation of Treatment Decision Algorithms for Childhood Tuberculosis

  This study is testing a new way to help doctors in Zambia and Mozambique make better decisions for screening and treating tuberculosis in children under 15 years old.

  Recruiting at 29 sites University of Zambia · Chingola, Copperbelt and 28 other locations · NCT06593080

• Understanding lung immune responses and microbiome after tuberculosis exposure

  This study looks at how the lungs' immune system and bacteria change in people who have recently been around someone with tuberculosis to help improve future vaccines.

  Recruiting at 3 sites University of Oxford · Oxford, Oxfordshire and 2 other locations · NCT06526689

• Registry to collect data on mycobacterial infections in Austria

  This study is collecting information from patients in Austria with mycobacterial infections to see how their treatment goes and what factors might affect their recovery.

  Recruiting at 3 sites Ludwig Boltzmann Institute for Lung Health · Vienna and 2 other locations · NCT06522347

• Dolutegravir plus lamivudine two-drug HIV treatment for people starting rifampin-based TB therapy

  This will test whether a two-drug HIV regimen (dolutegravir plus lamivudine), given either twice daily or as Dovato in the morning plus extra dolutegravir in the evening, works and is safe for ART‑naïve people with HIV who are receiving rifampin-based tuberculosis treatment compared with standard three‑drug therapy.

  Recruiting at 5 sites Phase 3 Johns Hopkins University · Manaus, Amazonas and 4 other locations · NCT06497465

• Evaluating a new test for diagnosing tuberculosis

  This study is testing a new tuberculosis test to see if it can accurately diagnose both active and latent cases in patients seeking treatment.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT06485895

• Doxycycline added to standard treatment for central nervous system tuberculosis

  This trial tests whether adding doxycycline to standard anti‑TB therapy and corticosteroids helps adults with central nervous system tuberculosis live longer or have less severe neurological disability.

  Recruiting at 5 sites Phase 2 National University Hospital, Singapore · Medan, Medan and 5 other locations · NCT06446245

• Doxycycline added to standard treatment for central nervous system tuberculosis

  This trial tests whether adding doxycycline to standard anti‑TB therapy and corticosteroids helps adults with central nervous system tuberculosis live longer or have less severe neurological disability.

  Recruiting at 5 sites Phase 2 National University Hospital, Singapore · Medan, Medan and 5 other locations · NCT06446245

• Improving tuberculosis case detection in low-resource settings

  This study is testing two different ways to find tuberculosis in healthcare centers in Guinea Bissau and Ethiopia to see which one helps diagnose and treat patients faster.

  Recruiting at 2 sites Aarhus University Hospital · Gonder and 1 other locations · NCT06437184

• Using BaidiZiyin and ShenqiYifei Pills to treat pulmonary tuberculosis

  This study is testing if adding BaidiZiyin and ShenqiYifei pills to standard treatment can help people newly diagnosed with pulmonary tuberculosis feel better and reduce side effects from their medication.

  Recruiting Phase 4 Beijing Chest Hospital · Beijing, Beijing Municipality · NCT06403943

• Cryobiopsy for diagnosing mediastinal conditions in Sweden

  This study is testing a new biopsy method to see if it helps doctors better diagnose lung and chest conditions like cancer and infections in patients.

  Recruiting at 2 sites Region Skane · Lund and 1 other locations · NCT06347939

• Comparing advice on moderate drinking versus abstention for health outcomes

  This study is testing whether giving advice on moderate drinking or complete abstention is better for the health of adults over 50 in Spain.

  Recruiting Clinica Universidad de Navarra, Universidad de Navarra · Pamplona, Navarre · NCT06338215

• Personalized rifampin dosing guided by a urine test

  This trial will test whether a simple urine spectrophotometry test can identify adults and children with low rifampin levels so clinicians can increase doses to reach target blood exposure during treatment for drug‑sensitive pulmonary TB.

  Recruiting Phase 1 University of Virginia · Haydom · NCT06318416

• Shortened treatment for tuberculosis in children

  This study is testing if a shorter 2-month treatment for tuberculosis works just as well and is safe for children under 10 as the usual 4- to 6-month treatment.

  Recruiting at 9 sites Phase 3 Johns Hopkins University · Chennai and 8 other locations · NCT06253715

• Understanding TB Infection Risks in Health Workers

  This study is trying to understand how health workers in Cape Town respond to tuberculosis infections over a year to find better ways to protect them from getting sick.

  Recruiting Beth Israel Deaconess Medical Center · Cape Town · NCT06221488

• Using Atorvastatin to treat Pulmonary Tuberculosis

  This study is testing if adding Atorvastatin, a cholesterol-lowering drug, can help people with pulmonary tuberculosis get better when they start treatment.

  Recruiting at 8 sites Phase 2 Obafemi Awolowo University Teaching Hospital · Zaria, Kaduna State and 7 other locations · NCT06199921

• Shortened treatment options for people with asymptomatic pulmonary TB

  This project tests whether people with bacteriologically confirmed but symptom-free pulmonary tuberculosis can be treated safely with a 17-week standard-drug course or a 13-week high-dose rifapentine plus moxifloxacin course instead of the longer standard regimen.

  Recruiting at 4 sites Phase 4 Huashan Hospital · Beijing, Beijing Municipality and 4 other locations · NCT06153069

• New diagnostic methods for pediatric tuberculosis in Bolivia

  This study is testing a new blood test to see if it can help doctors better diagnose tuberculosis in children in Bolivia.

  Recruiting Tulane University · Santa Cruz · NCT06113861

• Screening for latent tuberculosis in school contacts of active patients

  This study is testing how common tuberculosis infection is among students aged 13 and older who have been in close contact with active tuberculosis patients to improve screening methods in schools.

  Recruiting at 44 sites Huashan Hospital · Zunyi, Guiyang and 43 other locations · NCT06033807

• One-month treatment for latent tuberculosis in school contacts

  This study is testing if a one-month treatment for latent tuberculosis can help protect school-aged kids who have been in close contact with someone who has TB.

  Recruiting at 66 sites Phase 3 Huashan Hospital · Anshun, Guiyang and 65 other locations · NCT06022146

• Evaluating new TB diagnostic tests for children

  This study is testing new, easier ways to diagnose tuberculosis in children under 15 to help them get treated faster and reduce the risk of serious illness.

  Recruiting University of California, San Francisco · Maputo and 2 other locations · NCT05989802

• Evaluating the safety and immune response of MTBVAC in adolescents and adults with and without HIV in South Africa

  This study is testing the MTBVAC vaccine to see if it's safe and effective for adolescents and adults in South Africa, both with and without HIV, by comparing it to the BCG vaccine.

  Recruiting at 10 sites Phase 2 HIV Vaccine Trials Network · Johannesburg, Gauteng and 15 other locations · NCT05947890

• Evaluating new point-of-care tests for tuberculosis diagnosis

  This study is testing new quick tests for tuberculosis to see if they can help find more cases in people who show symptoms or are at risk, especially in countries where TB is common.

  Recruiting at 3 sites University of California, San Francisco · Abuja and 2 other locations · NCT05941052

• Peer-led TB and HIV education and adherence counseling in Uganda

  This trial will test whether peer-led TB education and counseling helps adults with tuberculosis (with or without HIV) stick to treatment and have better health outcomes.

  Recruiting Yale University · Kampala · NCT05917210

• Understanding immune cell behavior in sarcoidosis and tuberculosis

  This study is trying to understand how certain immune cells behave in people with sarcoidosis and tuberculosis to see what causes the ongoing inflammation in these conditions.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05916638

• Improving smoking cessation and HIV/TB treatment outcomes in South Africa

  This study is testing a new program to help people living with HIV and tuberculosis in Cape Town quit smoking to improve their overall health and treatment results.

  Recruiting Massachusetts General Hospital · Rondebosch · NCT05842161

• Examining Latent Tuberculosis Infection in Health-care Workers and Students

  This study looks at how many health care workers and students have Latent Tuberculosis Infection without symptoms and what factors might put them at risk.

  Recruiting Catholic University of the Sacred Heart · Roma · NCT05756582

• Community-based intervention to reduce tuberculosis among people who inject drugs in Vietnam

  This study is testing a new community program to help reduce tuberculosis among people who inject drugs in Hai Phong, Vietnam, by improving access to care and support.

  Recruiting at 2 sites ANRS, Emerging Infectious Diseases · Haiphong and 1 other locations · NCT05655702

• Gene expression profiles in spinal tuberculosis

  This study is trying to see if different gene patterns in spinal tuberculosis can help doctors better understand and treat the disease, especially in people with HIV.

  Recruiting University of Cape Town · Cape Town, Western Cape · NCT05610098

• COVID-19 vaccine immune responses in people being treated for tuberculosis

  This project tests whether people being treated for tuberculosis make the same antibody and T‑cell responses to Pfizer, AstraZeneca, or Janssen COVID‑19 vaccines as healthy adults.

  Recruiting University of Oxford · Mae Ramat, Changwat Tak · NCT05571735

• Comparing the effectiveness of tedizolid and linezolid for treating tuberculosis

  This study is testing if a new drug called tedizolid can work better than an existing drug, linezolid, in helping people with tuberculosis feel better by reducing the bacteria in their lungs.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Paris · NCT05534750

• Using doxycycline to improve lung function in tuberculosis patients

  This study is testing if adding doxycycline to the standard treatment for tuberculosis can help improve lung function and reduce damage in patients with lung infections.

  Recruiting at 3 sites Phase 3 National University Hospital, Singapore · Kota Kinabalu, Sabah and 5 other locations · NCT05473520

• Using cough sounds to identify tuberculosis

  This study is testing a smartphone app that listens to cough sounds to see if it can help identify tuberculosis in people who have been coughing for more than two weeks.

  Recruiting at 2 sites University of Stellenbosch · Cape Town, Western Cape and 1 other locations · NCT05317247

• Evaluating a new tuberculosis vaccine in newborns in Africa

  This study is testing a new tuberculosis vaccine for newborns in Africa to see if it works better than the standard vaccine and is safe for babies who don't have HIV.

  Recruiting Phase 3 Biofabri, S.L · Worcester, Western Cape · NCT04975178

• Improving tuberculosis diagnosis through innovative testing methods

  This study is testing new quick tests for tuberculosis to see if they can help health workers find the disease and drug resistance faster and improve care for patients.

  Recruiting at 16 sites University of California, San Francisco · Tbilisi and 15 other locations · NCT04923958

• High-dose treatment for recurrent tuberculosis

  This study is testing a higher dose of a new treatment for people with recurring tuberculosis to see if it works as well as the standard treatment.

  Recruiting Phase 3 Institute of Tropical Medicine, Belgium · Niamey · NCT04260477

• Understanding Paradoxical Reactions in Tuberculosis Treatment

  This study is trying to understand why some people without HIV have unexpected reactions while being treated for tuberculosis, by following their progress and collecting samples to find clues.

  Recruiting at 3 sites National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 2 other locations · NCT04052022

• Creating a new method to stage tuberculosis

  This study is trying to create a new way to stage tuberculosis by looking at different factors in patients to help improve how the disease is understood and managed.

  Recruiting at 5 sites Fundació Institut Germans Trias i Pujol · Badalona, Barcelona and 4 other locations · NCT03691883

• Understanding how anti-tuberculosis drugs work in children

  This study is trying to see how children's bodies process anti-tuberculosis drugs differently than adults to improve treatment for kids with tuberculosis.

  Recruiting Beijing Children's Hospital · Beijing · NCT03625739

• Improving tuberculosis diagnosis in Swiss children

  This study is testing new blood tests to see if they can better diagnose tuberculosis in children compared to current methods.

  Recruiting at 8 sites University Children's Hospital Basel · Aarau and 7 other locations · NCT03044509

• Long-term study of HIV patients in rural India

  This study looks at how HIV affects people living in rural India over time to see how well different treatments work and to understand the disease better.

  Recruiting Rural Development Trust Hospital · Battalapalli, Andhra Pradesh · NCT02454569

• Understanding the natural history of tuberculosis

  This study is trying to learn more about tuberculosis by collecting samples and monitoring treatment in people with active or latent TB to improve how we understand and treat the disease.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01212003

NIH-funded research (newest 40 of 522)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Coronary disease and immune activation in people with HIV and tuberculosis coinfection

  This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.

  NIH research Emory University · Atlanta, United States · NIH-11618831

• Pulmonary rehabilitation to reduce breathing problems after tuberculosis

  A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11607184

• Pulmonary rehab to reduce breathing troubles after TB

  A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11607183

• Air pollution and tuberculosis spread in Kampala, Uganda

  This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11579144

• Air pollution and TB spread in Ugandan urban slums

  This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11579143

• Air pollution and TB transmission in Kampala’s urban slums

  This project looks at whether air pollution from PM2.5 makes tuberculosis spread more easily from infected people to their neighbors in urban slums of Kampala, Uganda.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11579140

• Transdiagnostic therapy to improve mental health and TB treatment outcomes in India

  A doctor-research team will test a flexible mental health therapy called CETA to help people with tuberculosis who also struggle with depression and unhealthy alcohol use, aiming to improve their TB treatment success.

  NIH research Tufts University Boston · Boston, United States · NIH-11574759

• Nanobody-Based Diagnostics for Tuberculosis

  Aims to develop fast, multi-antigen TB tests using tiny antibody fragments to improve diagnosis for people with suspected TB, including those with HIV.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11572321

• M. tuberculosis phenylalanine production as a new drug target

  A small NIH grant explores whether blocking how tuberculosis bacteria make the amino acid phenylalanine could weaken the bacteria and help existing TB drugs work better.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11571605

• Automated chest X-ray reading for childhood TB (AI tools to help diagnose kids)

  A new AI tool helps doctors read chest X-rays to better detect tuberculosis in children, including those with HIV.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11565145

• Automated chest x-ray reading for childhood tuberculosis

  A pediatric-focused AI tool is being developed to read chest X-rays to help detect and manage tuberculosis in children, including those with HIV.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11565136

• Automated chest X-ray reading for diagnosing childhood TB (AI for kids and HIV)

  A pediatric-focused AI tool is being developed to read chest X-rays and help screen, diagnose, and guide treatment for children with TB, including those living with HIV.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11565120

• Shorter, rifamycin-free TB treatment using BCZD for drug-susceptible TB

  A 12-week, AI-informed drug combination (bedaquiline, clofazimine, pyrazinamide, and delamanid) is being tested against the standard 26-week therapy for adults with drug-susceptible TB to see if it can cure faster with fewer side effects.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11563787

• Shorter TB treatment using four drugs for drug-susceptible TB

  A 12-week, AI-informed drug regimen (bedaquiline, clofazimine, pyrazinamide, delamanid) is being tested against standard therapy for drug-susceptible TB to see if it works faster and safely across adults in Haiti and South Africa.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11563786

• How lung immune cells develop and metabolize to fight tuberculosis

  This project looks at how lung immune cells called alveolar macrophages behave and use energy to influence tuberculosis infection, with the goal of guiding better vaccines and therapies.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11558828

• TACTIC: Finding TB in people who use drugs through their social networks

  This project tests a peer-led recruitment approach to find TB cases among people who use drugs and their close contacts to speed up testing and treatment.

  NIH research Boston Medical Center · Boston, United States · NIH-11553412

• Single-cell view of lung macrophage roles in TB lesions

  A short, patient-friendly look at how different lung macrophages influence tuberculosis outcomes and lesion growth at the infection site.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11549671

• Short-Course TB Prevention for People with HIV: Better Adherence with Facilitated 3HP Delivery

  A trial tests easier, supportive ways to help people with HIV complete a short, weekly TB preventive treatment (3HP).

  NIH research University of California-Irvine · Irvine, United States · NIH-11549398

• Options for Delivering Short-Course TB Preventive Therapy for People with HIV

  A trial tests easier, shorter TB-prevention therapy (3HP) for people living with HIV to see if simplified support helps them complete treatment.

  NIH research University of California-Irvine · Irvine, United States · NIH-11549390

• Diagnostic Innovations for Pediatric Tuberculosis in Bolivia

  Aimed at improving TB diagnosis in children in Bolivia using a CRISPR-based blood test to detect TB DNA in serum.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11533816

• Geographic origins and spread of drug-resistant TB in South Africa: new ways to detect outbreaks early

  This grant supports a physician-scientist in Colorado to study how drug-resistant tuberculosis strains originate and spread, with the goal of spotting outbreaks early so patients and communities can be protected.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11524365

• Understanding how TB bacteria stay in the nose/throat before causing illness

  Researchers are studying how most people clear exposure to TB bacteria without getting sick, and why a small number eventually develop active TB or remain latent.

  NIH research University of Georgia · Athens, United States · NIH-11520349

• Poor bedaquiline response in drug-resistant TB in South Africa

  This project looks at why some people with drug-resistant tuberculosis in South Africa don’t respond well to bedaquiline and what factors predict worse outcomes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11519237

• Identifying biomarkers that predict TB disease risk in children with HIV

  Researchers will study stored samples from young children, including those with HIV, to find biological markers that signal who might develop TB or respond to treatment.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11519036

• Identifying biomarkers to predict tuberculosis risk in kids and HIV patients

  Researchers will study stored samples from young children and people with HIV to find biomarkers that signal who might progress to active TB and how they respond to treatment.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11519035

• Understanding why a lung immune cell fails to stop tuberculosis in early infection

  Researchers are studying a specific lung immune cell type to figure out why it sometimes doesn’t stop tuberculosis early, with the goal of improving vaccines or therapies for TB patients.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11515951

• Understanding lung problems that linger after TB treatment in Peru

  A study following people who were treated for TB in Lima, Peru to see what kinds of long-lasting lung problems they have and what factors put them at risk.

  NIH research Harvard Medical School · Boston, United States · NIH-11511777

• Automated lung sound analysis to help diagnose childhood tuberculosis

  A new AI tool that listens to kids’ lung sounds to help doctors decide if a child may have tuberculosis, aiming to be more accurate without invasive tests.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11509248

• Better detection and prevention of tuberculosis in prisons

  Using portable digital chest x-rays with automated reads, genetic tracking, and modeling to find and prevent tuberculosis among people in high-risk prisons in Brazil.

  NIH research Stanford University · Stanford, United States · NIH-11506639

• Rapid, non-culture based test for TB drug susceptibility using MPT64 biomarker

  A quick, non-culture test using the MPT64 biomarker to tell if tuberculosis bacteria will respond to key drugs, so people with drug-resistant TB can get the right treatment faster.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11503493

• Rapid, non-culture test to guide TB drug choices using the MPT64 biomarker

  A new, fast test uses the MPT64 biomarker to tell which tuberculosis bacteria are susceptible to drugs within 72 hours, directly from patient sputum.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11503491

• Predicting tuberculosis progression in young children with and without HIV

  This project will look for blood markers that show which young children with or without HIV are most likely to develop active tuberculosis so they can get earlier prevention or treatment.

  NIH research University of California-Irvine · Irvine, United States · NIH-11488586

• How TB progresses in young children with and without HIV

  This project looks for blood or other markers that can tell which young children with TB infection, including those living with HIV, are most likely to develop active TB so they can get preventive treatment early.

  NIH research University of California-Irvine · Irvine, United States · NIH-11488584

• Host glutamine metabolism in tuberculosis pathogenesis

  A study tests a drug that blocks host glutamine use to help fight tuberculosis by improving immune cells’ ability to kill the bacteria.

  NIH research Louisiana State Univ A&m Col Baton Rouge · Baton Rouge, United States · NIH-11473312

• Better medication support for people with drug-resistant TB and HIV in South Africa

  This project tries phone-based and in-person support to help people in South Africa with drug-resistant tuberculosis and HIV take their new TB and HIV medicines as prescribed.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11472087

• Better support for taking medicines for people with drug-resistant TB and HIV in South Africa

  This project tries combining mobile phone reminders and counseling to help people in South Africa with drug-resistant tuberculosis and HIV stick to their new medicines.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11472086

• New medicines to target TB bacteria hiding inside cells

  This project is developing new drugs designed to kill both active and hidden tuberculosis bacteria for people with drug-sensitive or drug-resistant TB.

  NIH research Tmliverpool School of Tropical Medicine · Liverpool, United Kingdom · NIH-11470111

• Urine color test to check tuberculosis drug levels in children and adults

  This project uses a simple urine color test to see whether children and adults with TB are getting enough of key TB medicines like rifampin.

  NIH research University of Virginia · Charlottesville, United States · NIH-11468977

• Brazil Tuberculosis (TB) Network for Patients and Contacts

  This project follows people with TB and their close contacts in Brazil to learn what helps with diagnosis, treatment, and prevention.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11468136

• Early lung imaging signs of tuberculosis

  This project builds computer-based CT and chest X-ray tools to spot early lung changes that may signal tuberculosis in people who don't yet have symptoms.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11466425

Related topics

Quick answers

How many Tuberculosis clinical trials are recruiting right now?

64, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 40 countries. The most sites are in South Africa (12 trials), China (9 trials), Uganda (7 trials), Spain (4 trials), Zambia (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 3: 7, Phase 1: 3, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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