Understanding the immune response in sarcoidosis and the effects of a specific treatment
Official title: Delineation of the immunobiology of sarcoidosis and characterization of the effects of Janus kinase inhibition
Funded at Yale University · NIH-10877021 · Data updated 2026-11-12
This study is looking at how a new type of medicine called JAK inhibitors might help treat sarcoidosis, especially for African Americans who haven't had success with other treatments, by examining skin and blood samples to learn more about the immune system's role in the disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $172,260 |
| NIH project number | 5K08AI159229-04 |
| Project ID | NIH-10877021 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with sarcoidosis, particularly those who have not responded well to existing treatments.
✕Less likely to help
Patients with sarcoidosis who are already responding well to current therapies may not benefit from this research.
What this research studies
This research investigates sarcoidosis, an inflammatory condition that leads to the formation of granulomas in various tissues, particularly affecting African Americans. The study aims to explore how Janus kinase (JAK) inhibitors can be used to treat sarcoidosis, especially in cases where other treatments have failed. By analyzing skin biopsies and blood samples from patients, researchers will create a detailed map of the immune signals involved in granuloma formation. This approach combines advanced techniques like single-cell RNA sequencing to better understand the disease and improve treatment options.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for sarcoidosis, improving patient outcomes and quality of life.
How similar studies have gone: Previous research has shown promise in using JAK inhibitors for treating other inflammatory conditions, suggesting potential success in this novel application for sarcoidosis.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Damsky, William — Yale University
- Study coordinator: Damsky, William
Related research
Other NIH-funded projects on the same topics.
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Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
-
Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
-
Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
-
Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.