Understanding how certain hormones affect granulomas in sarcoidosis
Official title: Redox Regulation of Sarcoidosis Granulomas and Fibrosis
Funded at Ohio State University · NIH-11129915 · Data updated 2026-11-12
This study is looking at how certain hormones might affect immune cells in people with sarcoidosis, a condition that causes inflammation, to find new ways to treat the disease and improve care for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 2, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $236,250 |
| NIH project number | 5R21AI180862-02 |
| Project ID | NIH-11129915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sarcoidosis who are experiencing granuloma formation and related symptoms.
✕Less likely to help
Patients with sarcoidosis who do not have granulomas or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the role of the renin-angiotensin-aldosterone system (RAAS) in the formation of granulomas associated with sarcoidosis, a disease characterized by inflammation and fibrosis. Using a novel ex vivo human granuloma model, researchers will explore how macrophages, a type of immune cell, are influenced by hormones like aldosterone, which may contribute to the disease's progression. The study aims to identify potential therapeutic targets and biomarkers that could lead to better treatment options for patients with sarcoidosis.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and fibrosis in sarcoidosis patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of hormonal regulation in granulomatous diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Crouser, Elliott D — Ohio State University
- Study coordinator: Crouser, Elliott D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.