Understanding the molecular features of progressive pulmonary sarcoidosis
Official title: Molecular Characterization of Progressive Pulmonary Sarcoidosis
Funded at National Jewish Health · NIH-10912435 · Data updated 2026-11-12
This study is looking at the unique proteins and genes in people with sarcoidosis to help find out who might be at risk for their lung condition getting worse, so we can create better ways to predict and manage the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $772,729 |
| NIH project number | 5R01HL162955-02 |
| Project ID | NIH-10912435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sarcoidosis, particularly those experiencing pulmonary symptoms.
✕Less likely to help
Patients with sarcoidosis who do not have pulmonary involvement or those with non-progressive forms of the disease may not benefit from this research.
What this research studies
This research investigates the molecular characteristics of progressive pulmonary sarcoidosis, a condition affecting the lungs in patients with sarcoidosis. By enrolling patients with sarcoidosis, the study aims to identify specific proteins and genes that could indicate a higher risk of disease progression. The research will utilize laboratory models and analyze blood samples to uncover biological pathways involved in the disease. The ultimate goal is to develop clinical tools for early prediction and management of progressive sarcoidosis.
Why it matters
Potential benefit: If successful, this research could lead to earlier identification and treatment of patients at risk for severe lung complications from sarcoidosis.
How similar studies have gone: While there have been studies on sarcoidosis, this research aims to explore novel molecular pathways that have not been extensively investigated, making it a potentially groundbreaking approach.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Maier, Lisa a — National Jewish Health
- Study coordinator: Maier, Lisa a
Related research
Other NIH-funded projects on the same topics.
-
Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
-
Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
-
Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
-
Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.