Condition

Hypertrophic Cardiomyopathy clinical trials and research

• 21Clinical trials
• 39NIH research projects
• 13Countries

Newest Hypertrophic Cardiomyopathy clinical trials

All recruiting trials (21)

• Mavacamten for symptomatic obstructive hypertrophic cardiomyopathy in Chinese adults

  This project will test how well mavacamten works for Chinese adults with symptomatic obstructive hypertrophic cardiomyopathy when used in everyday clinical care.

  Recruiting at 10 sites Bristol-Myers Squibb · Beijing, Beijing Municipality and 14 other locations · NCT07361289

• Long-term safety of HRS-1893 for people with hypertrophic cardiomyopathy

  This study tests the long-term safety of the oral drug HRS-1893 in people with hypertrophic cardiomyopathy who previously received HRS-1893.

  Recruiting Phase 2 Shandong Suncadia Medicine Co., Ltd. · Beijing, Beijing Municipality · NCT07021963

• Study of heart conditions using advanced imaging techniques

  This study is trying to find out what causes different heart conditions in Hispanic and African American people in the Bronx by using advanced imaging techniques.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT06610019

• Registry for Rare Diseases

  This study is creating a detailed registry to collect information on rare diseases like amyloidosis and sarcoidosis to help improve how they are diagnosed and treated.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires · NCT06573723

• Comparing inspiratory muscle training and Baduanjin exercises for heart health

  This study tests whether breathing exercises or a special exercise program can help people with hypertrophic cardiomyopathy improve their lung function, exercise ability, and overall quality of life.

  Recruiting Istanbul University - Cerrahpasa · Istanbul · NCT06490250

• Using advanced imaging to evaluate heart muscle scarring in various heart conditions

  This study is testing a new imaging method to see how heart scarring changes over time in people with certain heart conditions.

  Recruiting University of Edinburgh · Edinburgh, Scotland · NCT06409585

• Registry for Hypertrophic Cardiomyopathy in Taiwan

  This study is trying to gather information about hypertrophic cardiomyopathy and related diseases in adults in Taiwan to improve how they are diagnosed and treated.

  Recruiting Far Eastern Memorial Hospital · New Taipei City · NCT06381778

• Registry for patients with Hypertrophic Cardiomyopathy in Austria

  This study is gathering information from patients with Hypertrophic Cardiomyopathy in Austria to see how their symptoms and genetics can help improve understanding and treatment of the condition.

  Recruiting at 14 sites Medical University of Graz · Linz, Linz and 14 other locations · NCT06368518

• Monitoring the effects of mavacamten during pregnancy and breastfeeding

  This study is testing how safe the heart medication mavacamten is for mothers and their babies during pregnancy and breastfeeding.

  Recruiting Bristol-Myers Squibb · Wilmington, North Carolina · NCT05939700

• Program to understand and treat Hypertrophic Cardiomyopathy in Egypt

  This study is trying to understand Hypertrophic Cardiomyopathy in Egypt by looking at how common it is, how it affects people, and finding better treatment options for patients and their families.

  Recruiting Magdi Yacoub Heart Foundation · Aswān · NCT05884892

• Evaluating the safety of TN-201 in adults with a specific heart condition

  This study is testing a new gene therapy called TN-201 to see if it is safe for adults with a specific heart condition related to MYBPC3 mutations.

  Recruiting at 5 sites Phase 1/2 Tenaya Therapeutics · La Jolla, California and 9 other locations · NCT05836259

• Evaluating exercise training for patients with hypertrophic cardiomyopathy

  This study is testing if a moderate exercise program can help people with hypertrophic cardiomyopathy feel better and improve their heart function compared to just their usual activities.

  Recruiting University of California, San Francisco · San Francisco, California · NCT05818605

• Observing the causes and progression of cardiomyopathy

  This study is trying to understand what causes cardiomyopathy and how it gets worse by collecting DNA, blood samples, and health information from people with the condition or those at risk.

  Recruiting at 2 sites Imperial College London · London and 1 other locations · NCT05750147

• Hypertrophic Cardiomyopathy Registry, Biobank, and Imaging Data Repository

  This project tests whether collecting genetic, imaging, and clinical data from people with hypertrophic cardiomyopathy can help predict outcomes and better understand the disease.

  Recruiting at 15 sites Montreal Heart Institute · Edmonton, Alberta and 16 other locations · NCT05100420

• New imaging protocol for heart conditions

  This study is testing a new imaging method for heart conditions to see if it can improve diagnosis and treatment for over 10,000 patients with heart issues.

  Recruiting Fatebenefratelli Hospital · Benevento · NCT05081115

• A quick 10-minute heart scan for cardiac diseases

  This study is testing a quick 10-minute heart scan to see if it can help diagnose heart problems better and faster for many patients without needing special dyes.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04464655

• Improving decisions for defibrillator implantation in hypertrophic cardiomyopathy

  This study is trying to create a better way to decide if people with hypertrophic cardiomyopathy should get a defibrillator to prevent sudden cardiac death by using new tests and information.

  Recruiting Assistance Publique - Hôpitaux de Paris · Boulogne-Billancourt, Hauts-de-Seine · NCT03846297

• Evaluating heart involvement in patients with Fabry disease

  This study looks at patients with Fabry disease to see what factors might lead to heart problems like arrhythmias and heart failure.

  Recruiting Wuerzburg University Hospital · Würzburg, Bavaria · NCT03362164

• Collecting biological samples and imaging data to study heart health and disease

  This study is collecting health information and samples from people with heart conditions and healthy volunteers to learn more about heart health and disease.

  Recruiting National Heart Centre Singapore · Singapore, Singapore · NCT02804269

• Analyzing genetic mutations in pediatric cardiomyopathy

  This study is trying to learn more about the genetic causes of heart problems in children with cardiomyopathy to help improve diagnosis and treatment options for them.

  Recruiting Indiana University · Indianapolis, Indiana · NCT02432092

• Observing patients with hypertrophic cardiomyopathy in France

  This study is tracking patients with hypertrophic cardiomyopathy in France to see how their health changes over time and to improve treatment for the condition.

  Recruiting French Cardiology Society · Paris · NCT01091480

NIH-funded research (39)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• SGLT inhibitors for non-obstructive hypertrophic cardiomyopathy

  A testing of a diabetes drug class (SGLT2 inhibitors) to help people with non-obstructive hypertrophic cardiomyopathy feel better and reduce heart-related problems.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11412600

• Using big biobanks to understand rare gene changes in hypertrophic cardiomyopathy

  A large study will look at genetic data and health information from many people to better understand how rare gene changes influence hypertrophic cardiomyopathy and its risks.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11411152

• Understanding heart disease in hypertrophic cardiomyopathy through heart tissue and blood analysis

  Researchers are studying people with hypertrophic cardiomyopathy to see how genes and signaling in heart tissue and blood relate to disease progression and risk of serious heart problems.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11395391

• Myosin binding protein C variants and heart disease

  A doctor-scientist at the University of Michigan is studying how certain genetic changes in a heart protein (MYBPC3) cause hypertrophic cardiomyopathy and whether fixing the protein or its interactions could help people with this condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11377477

• MEK inhibitor for severe infantile heart failure in Noonan and related RASopathies

  A 12-month, multi-site trial tests whether the medicine trametinib can help infants with life-threatening heart failure due to Noonan syndrome and related genetic conditions.

  NIH research New England Research Institutes, INC. · Wilmington, UNITED STATES · NIH-11351068

• MEK inhibitor shows promise for serious infant heart disease in Noonan/RASopathies

  A multi-site study tests whether the drug trametinib can help infants with severe heart muscle thickening caused by Noonan syndrome and related RASopathies.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11349726

• Boosting heart cell energy in hypertrophic cardiomyopathy

  New approaches to improve mitochondrial energy in heart cells for people with hypertrophic cardiomyopathy.

  NIH research Boston Medical Center · Boston, United States · NIH-11323876

• High-Intensity Ultrasound to Shrink the Septum in Hypertrophic Cardiomyopathy

  A new, less invasive ultrasound-based treatment is being developed to reduce the thickened heart septum in people with obstructive hypertrophic cardiomyopathy.

  NIH research University of Washington · Seattle, United States · NIH-11307669

• How exercise heart MRI could explain heart failure in hypertrophic cardiomyopathy

  Using exercise cardiac MRI, researchers will look at why people with hypertrophic cardiomyopathy develop heart failure and how treatments like the drug mavacamten compare with surgery.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11291323

• Gene changes in protein quality control that influence hypertrophic cardiomyopathy

  This project looks at whether common genetic variants in protein-quality-control genes change disease severity in people with hypertrophic cardiomyopathy.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11245770

• How MYBPC3 gene changes lead to thickened heart muscle (hypertrophic cardiomyopathy)

  This project looks at how specific changes in the MYBPC3 gene disturb heart muscle proteins in people with hypertrophic cardiomyopathy to point toward better treatments.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11193969

• How mechanical stress interacts with MYBPC3 gene changes in hypertrophic cardiomyopathy

  Looks at whether extra mechanical stress on the heart makes people with MYBPC3 gene changes develop or keep hypertrophic cardiomyopathy, using tiny lab-grown human heart tissues.

  NIH research Washington University · Saint Louis, United States · NIH-11166519

• SGLT2 inhibitor treatment for non-obstructive hypertrophic cardiomyopathy

  This project will try giving an SGLT2 diabetes medicine to people with non-obstructive hypertrophic cardiomyopathy to see if it is safe and helps symptoms and heart energy.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11161492

• Using large biobanks to find rare genetic changes in hypertrophic cardiomyopathy

  This project uses genetic and health data from big biobanks to find rare DNA changes that explain who gets hypertrophic cardiomyopathy and when.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11158971

• Understanding the causes of hypertrophic cardiomyopathy in children and adolescents

  This study is looking at how changes in a specific gene related to hypertrophic cardiomyopathy (HCM) affect the heart, using special lab models to better understand the disease in young people, with the hope of finding new treatments to help those with HCM live healthier lives.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11110171

• Using heart tissue and blood to predict dangerous events in hypertrophic cardiomyopathy

  This project looks at RNA patterns in heart tissue and blood from people with hypertrophic cardiomyopathy to find signals that predict dangerous events like arrhythmias, heart failure, or sudden death.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11089337

• Investigating how specific mutations affect heart function in hypertrophic cardiomyopathy.

  This study is looking at how certain genetic changes in heart proteins affect a key enzyme that helps your heart work properly, with the goal of finding better treatments for people with hypertrophic cardiomyopathy (HCM).

  NIH research University of Arizona · Tucson, United States · NIH-11064966

• Improving heart function in patients with hypertrophic cardiomyopathy

  This study is looking at ways to improve how heart cells produce energy in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle is too thick, to help slow down or even reverse the problems it causes.

  NIH research Boston Medical Center · Boston, United States · NIH-11063988

• Understanding heart muscle changes in hypertrophic cardiomyopathy to predict serious heart events

  This study is looking at hypertrophic cardiomyopathy (HCM), a heart condition that can cause serious problems, to find out how it affects people and to help doctors better predict who might be at risk for complications, so they can provide better care over time.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11063799

• Using ultrasound to treat obstructive hypertrophic cardiomyopathy

  This study is testing a new, less invasive treatment for people with obstructive hypertrophic cardiomyopathy (oHCM) that uses ultrasound to help reduce heart muscle blockage, making it a safer option than traditional surgery.

  NIH research Coridea, LLC · New York, United States · NIH-11063380

• Understanding exercise intolerance in patients with non-obstructive hypertrophic cardiomyopathy

  This study is looking at how exercise affects people with non-obstructive hypertrophic cardiomyopathy (HCM) and aims to find out if exercise training can help improve heart function and make it easier for them to be active, ultimately enhancing their quality of life.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11045757

• Using high-intensity ultrasound to treat heart obstruction in hypertrophic cardiomyopathy

  This study is testing a new, less invasive ultrasound treatment for people with obstructive hypertrophic cardiomyopathy (HCM) to help reduce heart muscle thickness and improve heart function.

  NIH research University of Washington · Seattle, United States · NIH-11038040

• Investigating genetic factors in heart disease caused by MYH7 variants

  This study is looking at how certain changes in a gene called MYH7 can affect people with hypertrophic cardiomyopathy (HCM), helping to explain why some patients have different symptoms and providing useful information for them and their doctors.

  NIH research University of Washington · Seattle, United States · NIH-11032231

• Improving screening for hypertrophic cardiomyopathy using advanced technology

  This study is working on a new way to help doctors quickly and accurately spot hypertrophic cardiomyopathy (HCM) using smart technology and wearable devices, making it easier for everyone to get checked for this heart condition.

  NIH research Yale University · New Haven, United States · NIH-11031296

• Understanding heart failure in patients with hypertrophic cardiomyopathy through advanced imaging techniques.

  This study is looking at how heart failure happens in people with hypertrophic cardiomyopathy (HCM) and how a new medication called mavacamten might help, using special heart scans to understand their condition better.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11029028

• Understanding how myosin mutations cause heart disease

  This study is looking at how certain changes in a heart protein can cause thickening of the heart muscle in people with hypertrophic cardiomyopathy (HCM), and it aims to find better, personalized treatments for those affected by this condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11013826

• Investigating genetic factors that influence hypertrophic cardiomyopathy

  This study is looking at how certain genes related to heart muscle health might influence the symptoms and severity of hypertrophic cardiomyopathy (HCM), and it invites patients to share their genetic samples to help uncover these connections.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11001241

• Investigating the role of serotonin-2B receptors in heart disease

  This study is looking at how certain receptors in the heart might play a role in a serious heart condition called hypertrophic cardiomyopathy (HCM), which can be dangerous for young adults, and it aims to find new ways to help reduce heart scarring and improve heart health.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11001126

• Investigating a new treatment for heart disease caused by thickened heart muscle.

  This study is looking at a new treatment using a special version of a heart-related protein called CNP to see if it can help people with hypertrophic cardiomyopathy (HCM) by reducing heart muscle thickening and improving their condition.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11000261

• Understanding rare genetic variants in hypertrophic cardiomyopathy

  This study is looking at how certain genes might influence hypertrophic cardiomyopathy (HCM), a heart condition, by collecting and analyzing genetic information from different groups of people to better understand what causes the disease and how it affects individuals.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10999711

• Investigating SGLT2 inhibitors for treating hypertrophic cardiomyopathy

  This study is looking at whether a diabetes medication called SGLT2 inhibitors can help people with non-obstructive hypertrophic cardiomyopathy (HCM) feel better and improve their heart function, giving them more treatment options for their condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10923375

• Exploring how mechanical stress affects heart disease linked to specific genetic mutations.

  This study is looking at how extra strain on the heart affects people with a common inherited heart condition called Hypertrophic Cardiomyopathy (HCM), especially those with specific genetic changes, to help find better treatments that fit each person's needs.

  NIH research Washington University · Saint Louis, United States · NIH-10914885

• Understanding genetic changes in a heart protein linked to hypertrophic cardiomyopathy

  This study is looking at how certain changes in a gene related to heart muscle can affect people with hypertrophic cardiomyopathy (HCM), which can cause serious heart issues, to help find better ways to understand and treat the condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10913579

• Using machine learning to better detect hypertrophic cardiomyopathy from health records

  This study is working on using advanced computer technology to help find people who might have hypertrophic cardiomyopathy, a heart condition that often runs in families, even if they haven't been diagnosed yet, so they can get the care they need sooner.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10910166

• Understanding the different ways hypertrophic cardiomyopathy affects patients

  This study is looking into why some people with hypertrophic cardiomyopathy (HCM) have more severe symptoms than others, using genetic and health information to help improve how we diagnose and manage this heart condition.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10903810

• Understanding how certain genetic changes in a heart protein cause hypertrophic cardiomyopathy

  This study is looking into how certain genetic changes in a heart protein might cause hypertrophic cardiomyopathy (HCM) and whether new treatments can help fix these issues, so it's especially for people with HCM who want to understand more about their condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10896913

• Understanding how specific mutations in a heart protein cause genetic heart disease

  This study is looking at how changes in a gene important for heart muscle work can cause familial hypertrophic cardiomyopathy (HCM), and it aims to understand these changes better to help find new treatments for people with this condition.

  NIH research University of Washington · Seattle, United States · NIH-10885119

• Using ultrasound to treat obstructive hypertrophic cardiomyopathy

  This study is testing a new, less invasive ultrasound treatment for people with obstructive hypertrophic cardiomyopathy (oHCM) to help reduce heart blockage safely, especially for those who can't have traditional surgery.

  NIH research Coridea, LLC · New York, United States · NIH-10834827

• A new method to treat heart muscle thickening in patients who can't have surgery

  This study is exploring a new, safer way to treat hypertrophic cardiomyopathy (HCM) by using a gentle technique to help reduce the thickened heart muscle, so patients can feel better without needing major surgery.

  NIH research University of Texas Arlington · Arlington, United States · NIH-10514872

Related topics

Quick answers

How many Hypertrophic Cardiomyopathy clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (5 trials), China (2 trials), France (2 trials), United Kingdom (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →