Understanding immune cell behavior in sarcoidosis and tuberculosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the role of monocytes and macrophages in the formation and maintenance of granulomas in patients with sarcoidosis and tuberculosis. By comparing these two conditions, the study will define a systemic signature of immune cells using blood samples and tissue analysis through advanced techniques such as multi-parameter spectral flow cytometry and RNA sequencing. The research seeks to identify the factors contributing to chronic immune cell overactivation, which may provide insights into the pathophysiology of granulomatous diseases.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Male and female \> 18 years old
2. Diagnosis of sarcoidosis and of tuberculosis
3. Affiliated to medical insurance

Exclusion criteria:

1. HIV infection
2. pregnant or breastfeeding woman
3. Patient under legal protection, guardianship or curators
4. Absence of signed consent" Secondary exclusion criteria Other causes of granulomatosis ultimately identified as sarcoidosis or tuberculosis

Where it's running

• Hôpital Bichat
  Paris, France Recruiting

Study contacts

• Principal investigator: Karim SACRE, MD-PhD, PU-PH — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Karim Sacre, MD-PhD, PU-PH
• Email: karim.sacre@aphp.fr
• Phone: 0140256019

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.