Predicting future lung health in sarcoidosis
Development of Clinical Prediction Models for Pulmonary Outcomes in Sarcoidosis
This project is building tools to predict which people with pulmonary sarcoidosis will have meaningful drops in lung function using routine clinic data and new blood markers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11378898 on NIH RePORTER |
What this research studies
From your perspective, researchers will use your clinic records and standard lab tests to build models that forecast meaningful declines in lung function over time. First they will create a prediction tool that relies only on data commonly available in pulmonary clinics so results can be used right away. Next they will test whether adding blood protein and RNA markers tied to interferon inflammation improves those predictions. They will use time-to-event statistics and performance metrics to pick the most useful risk model for clinical use.
Who could benefit from this research
Good fit: Adults with pulmonary sarcoidosis who receive regular lung function testing and can provide blood samples are the most suitable candidates for this work.
Not a fit: People without lung involvement from sarcoidosis, those not receiving lung function monitoring, or those without available blood samples are unlikely to gain direct benefit from the prediction tools.
Why it matters
Potential benefit: If successful, these tools could help doctors identify people at higher risk of lung decline so care and monitoring can be personalized.
How similar studies have performed: Prior research has linked interferon-related blood proteins and RNA to lung outcomes, but combining these markers into validated clinical prediction models is relatively new.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Koth, Laura L — University of California, San Francisco
- Study coordinator: Koth, Laura L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.