Predicting future lung health in sarcoidosis
Official title: Development of Clinical Prediction Models for Pulmonary Outcomes in Sarcoidosis
Funded at University of California, San Francisco · NIH-11378898 · Data updated 2026-11-12
This project is building tools to predict which people with pulmonary sarcoidosis will have meaningful drops in lung function using routine clinic data and new blood markers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $128,372 |
| NIH project number | 3R01HL157533-04S1 |
| Project ID | NIH-11378898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with pulmonary sarcoidosis who receive regular lung function testing and can provide blood samples are the most suitable candidates for this work.
✕Less likely to help
People without lung involvement from sarcoidosis, those not receiving lung function monitoring, or those without available blood samples are unlikely to gain direct benefit from the prediction tools.
What this research studies
From your perspective, researchers will use your clinic records and standard lab tests to build models that forecast meaningful declines in lung function over time. First they will create a prediction tool that relies only on data commonly available in pulmonary clinics so results can be used right away. Next they will test whether adding blood protein and RNA markers tied to interferon inflammation improves those predictions. They will use time-to-event statistics and performance metrics to pick the most useful risk model for clinical use.
Why it matters
Potential benefit: If successful, these tools could help doctors identify people at higher risk of lung decline so care and monitoring can be personalized.
How similar studies have gone: Prior research has linked interferon-related blood proteins and RNA to lung outcomes, but combining these markers into validated clinical prediction models is relatively new.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Koth, Laura L — University of California, San Francisco
- Study coordinator: Koth, Laura L
Related research
Other NIH-funded projects on the same topics.
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Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
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Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
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Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
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Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
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Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
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Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.