Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis

Who could benefit from this research

What this research studies

This project will use advanced PET and MRI imaging to monitor heart inflammation and damage in people with active cardiac sarcoidosis who are receiving immune-suppressant therapy. Researchers will compare multiple imaging markers over time to identify which ones best reflect treatment response. The goal is to establish practical imaging thresholds that help clinicians decide whether a patient’s therapy is working. Participants will undergo repeat imaging studies and safety monitoring as part of standard care coordination.

Why it matters

Where this research is happening

• Icahn School of Medicine at Mount Sinai
  New York, United States Active

Researchers

• Principal investigator: Fayad, Zahi a. — Icahn School of Medicine at Mount Sinai
• Study coordinator: Fayad, Zahi a.

Related research

Other NIH-funded projects on the same topics.

• Precision PET attenuation correction for heart PET/MR imaging

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  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11378430

• CXCR3 Blockade as a Targeted Therapy for Cardiac Sarcoidosis

  A study to see if blocking CXCR3 can help treat heart involvement in sarcoidosis patients using advanced immune profiling and a mouse model.

  NIH research Stanford University · Stanford, United States · NIH-11372257

• MRI and PET scans to track treatment response in active cardiac sarcoidosis

  This project uses PET and MRI scans with advanced imaging measures and AI to monitor how people with active cardiac sarcoidosis respond to immune-suppressing treatments.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11141926

• Investigating imaging responses to immune suppressant therapy in cardiac sarcoidosis patients

  This study is looking at how well certain imaging tests can show if patients with cardiac sarcoidosis are responding to their immune-suppressing treatments, with the goal of finding better ways to help them feel better.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10999907

• Integrative metabolomics to improve sarcoidosis diagnosis and prognosis

  A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11496248

• Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism

  Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11451047

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.