Understanding why sarcoidosis happens and how it affects people using multi-omics
Official title: Understanding Sarcoidosis Susceptibility and Disease Burden Through Multi Omics
Funded at Oklahoma Medical Research Foundation · NIH-11387839 · Data updated 2026-11-12
A multi-omics study aims to uncover why sarcoidosis affects people differently and to find biomarkers that predict disease burden.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | August 1, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $741,462 |
| NIH project number | 5R01HL175157-02 |
| Project ID | NIH-11387839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals diagnosed with sarcoidosis, especially those with African ancestry or African American women, may be eligible.
✕Less likely to help
Some participants may not experience direct benefits during the study, but findings could still inform future care.
What this research studies
This project uses genetic, transcriptomic, and other biological data from people with sarcoidosis to understand what drives the disease and its outcomes. Researchers will analyze samples and clinical information to link cellular and molecular signals to organ involvement and severity. The work builds on prior single-cell and genetic studies to identify mechanisms and potential biomarkers that reflect patient-specific disease activity. By integrating diverse data, the team hopes to reveal targets for better diagnosis and personalized care for those with sarcoidosis.
Why it matters
Potential benefit: If successful, patients could receive earlier and more accurate diagnoses and more personalized treatment plans.
How similar studies have gone: Previous studies have identified genetic and transcriptomic factors in sarcoidosis and demonstrated the value of multi-omics approaches for understanding complex diseases.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Montgomery, Courtney — Oklahoma Medical Research Foundation
- Study coordinator: Montgomery, Courtney
Related research
Other NIH-funded projects on the same topics.
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Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
-
Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
-
Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
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Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.