Investigating how a hormone system affects granuloma formation in sarcoidosis
Official title: Role of Renin-Angiotensin-Aldosterone System during sarcoidosis granuloma formation
Funded at Ohio State University · NIH-10744243 · Data updated 2026-11-12
This study is looking at how a system in your body called RAAS affects the growth of granulomas in sarcoidosis, and it hopes to find new ways to help people with this condition by testing if blocking certain parts of this system can reduce granuloma formation.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | November 18, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $236,250 |
| NIH project number | 5R21AI168804-02 |
| Project ID | NIH-10744243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sarcoidosis who are experiencing granuloma formation.
✕Less likely to help
Patients with sarcoidosis who do not have granuloma formation may not benefit from this research.
What this research studies
This research explores the role of the renin-angiotensin-aldosterone system (RAAS) in the formation of granulomas in sarcoidosis, a disease characterized by inflammation and granuloma development. Using a novel in vitro human granuloma model, the study aims to understand how macrophages, influenced by RAAS, contribute to this process. The researchers will examine the effects of inhibiting certain pathways within RAAS to see if it can reduce granuloma formation, potentially leading to new treatment strategies for patients with sarcoidosis.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets and biomarkers for treating sarcoidosis.
How similar studies have gone: Previous research has indicated a link between the RAAS system and granuloma formation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Crouser, Elliott D — Ohio State University
- Study coordinator: Crouser, Elliott D
Related research
Other NIH-funded projects on the same topics.
-
Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
-
Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
-
Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
-
Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.