Predicting Lung Changes in Sarcoidosis
Official title: Development of Clinical Prediction Models for Pulmonary Outcomes in Sarcoidosis
Funded at University of California, San Francisco · NIH-11078189 · Data updated 2026-11-12
This project aims to create new tools that help doctors understand how lung sarcoidosis might progress for individual patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $994,512 |
| NIH project number | 5R01HL157533-04 |
| Project ID | NIH-11078189 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for patients diagnosed with pulmonary sarcoidosis, especially those interested in how their disease might progress.
✕Less likely to help
Patients without pulmonary sarcoidosis or those whose sarcoidosis affects other organs without lung involvement may not directly benefit from these specific prediction tools.
What this research studies
Living with sarcoidosis can be challenging because it's hard to know if your condition will improve, stay the same, or worsen over time. This project seeks to develop better ways to predict how lung function might change in people with sarcoidosis, which can help doctors create more personalized care plans. Researchers will use existing clinical information and blood tests to build a prediction tool, and then see if adding new blood markers related to inflammation makes these predictions even more accurate. The goal is to provide doctors with practical tools they can use right away to improve long-term care for patients.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more personalized treatment plans for people with pulmonary sarcoidosis, potentially preventing severe lung problems.
How similar studies have gone: Preliminary data has shown that certain blood markers can predict future declines in lung function, providing a foundation for this new model development.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Koth, Laura L — University of California, San Francisco
- Study coordinator: Koth, Laura L
Related research
Other NIH-funded projects on the same topics.
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Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
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Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
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Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
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Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
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Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
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Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.