Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
Official title: Integrative Metabolomics of Sarcoidosis Diagnosis and Progression
Funded at University of California Los Angeles · NIH-11496248 · Data updated 2026-11-12
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $695,935 |
| NIH project number | 7R01HL173239-02 |
| Project ID | NIH-11496248 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals suspected of having sarcoidosis or with a confirmed diagnosis, including African American women and other diverse groups, who are able to provide blood samples and follow-up data.
✕Less likely to help
Patients whose disease is not sarcoidosis or who cannot participate in follow-up blood testing may not benefit.
What this research studies
This project will analyze patient blood samples to identify metabolite patterns linked to sarcoidosis and its progression. By comparing diverse groups, including African American women, researchers hope to find signatures that distinguish patients from healthy individuals and indicate who is at higher risk of worse outcomes. The study builds on preliminary metabolomics data and uses multiple metabolic markers to develop a clearer picture of the disease. If successful, these biomarkers could lead to earlier diagnosis and more tailored treatment decisions for patients.
Why it matters
Potential benefit: If successful, patients could receive faster, more accurate diagnosis and better-informed treatment plans based on their biomarker profile.
How similar studies have gone: Previous metabolomics studies showed detectable differences between sarcoidosis patients and controls, supporting the potential approach but further validation is needed.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Liao, Shu-Yi — University of California Los Angeles
- Study coordinator: Liao, Shu-Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.