Condition

Idiopathic Inflammatory Myopathies clinical trials and research

• 15Clinical trials
• 5NIH research projects
• 13Countries

Newest Idiopathic Inflammatory Myopathies clinical trials

All recruiting trials (15)

• MTS109 treatment for refractory autoimmune diseases

  This trial tests whether MTS109 (an mRNA-LNP given by subcutaneous injection) is safe and tolerable in adults with moderate to severe autoimmune diseases that have not responded to standard treatments.

  Recruiting Early Phase 1 Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT07526350

• AZD0120 CD19/BCMA CAR T-cell therapy for systemic sclerosis, inflammatory myopathies, and difficult-to-treat rheumatoid arthritis

  This trial will try a dual-targeting CD19/BCMA CAR T-cell treatment (AZD0120) in adults with systemic sclerosis, idiopathic inflammatory myopathies, or difficult-to-treat rheumatoid arthritis to see if it is safe and well tolerated.

  Recruiting at 5 sites Phase 1/2 AstraZeneca · Tucson, Arizona and 26 other locations · NCT07295847

• Phase 1 safety test of XmAb657 in healthy adults and people with myositis, scleroderma, or Sjögren's

  This study will test whether subcutaneous injections of XmAb657 are safe and well tolerated in healthy adults and people with autoimmune diseases such as idiopathic inflammatory myopathies, systemic sclerosis, or primary Sjögren's syndrome.

  Recruiting Phase 1 Xencor, Inc. · Melbourne · NCT07284797

• Imaging in Inflammatory Heart Diseases linked to autoimmune disorders

  This study tests how well multimodality imaging (CMR, echocardiography, and PET) detects inflammation in people with suspected inflammatory heart or autoimmune rheumatic diseases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07077304

• BAFF‑R CAR T‑cell treatment for refractory neuroimmune diseases

  This trial will try personalized BAFF‑R CAR T cells to reduce disease activity in people with hard‑to‑treat conditions such as CIDP, NMOSD, myasthenia gravis, and inflammatory myopathies.

  Recruiting Phase 1/2 Tianjin Medical University General Hospital · Tianjin, Tianjin Municipality · NCT07022197

• Investigating AZD5492 for treating systemic lupus erythematosus and inflammatory myopathies

  This study is testing a new medication called AZD5492 to see if it can safely help adults with systemic lupus erythematosus and inflammatory myopathies feel better.

  Recruiting at 33 sites Phase 1 AstraZeneca · Anniston, Alabama and 37 other locations · NCT06916806

• Using engineered natural killer cells to treat immune-mediated diseases

  This study is testing a new type of cell therapy called NKX019 to see if it can safely help people with immune-related diseases like systemic sclerosis and certain types of myopathies.

  Recruiting at 12 sites Phase 1/2 Nkarta, Inc. · Los Angeles, California and 11 other locations · NCT06733935

• Investigating the Role of Y Chromosome Mutations in Autoimmune Diseases

  This study is trying to see how changes in the Y chromosome might affect the immune system and contribute to autoimmune diseases like Giant Cell Arteritis and Polymyalgia Rheumatica.

  Recruiting University of Bonn · Bonn, North Rhine-Westphalia · NCT06696027

• Targeted CAR-T therapy for autoimmune diseases

  This study is testing a new type of CAR-T therapy to see if it can help people with active autoimmune diseases feel better and manage their symptoms.

  Recruiting Early Phase 1 Nanjing Bioheng Biotech Co., Ltd. · Bengbu, Anhui · NCT06548607

• Identifying biomarkers for autoimmune diseases affecting the nervous system

  This study is trying to find specific markers in the blood of people with autoimmune diseases affecting the nervous system, like Multiple Sclerosis, to help with early diagnosis and better treatment options.

  Recruiting Tongji Hospital · Wuhan · NCT06502015

• Combination therapy for sporadic inclusion body myositis

  This study is testing a new combination treatment with Pozelimab and Cemdisiran to see if it can help people with sporadic inclusion body myositis feel better.

  Recruiting at 2 sites Early Phase 1 Austin Neuromuscular Center · Austin, Texas and 1 other locations · NCT06479863

• Exploring a new drug for rare immune-related inflammatory diseases

  This study is testing a new drug called Filgotinib to see if it can help people with rare immune-related inflammatory diseases feel better and reduce their symptoms.

  Recruiting at 6 sites Phase 2 UMC Utrecht · Amsterdam and 5 other locations · NCT06285539

• Collection of data and samples from adults with suspected inflammatory myopathy

  This study is collecting health information and samples from adults who might have inflammatory myopathy to help improve understanding and treatment of the condition.

  Recruiting University Hospital, Brest · Brest · NCT04792931

• Using CT103A cells to treat autoimmune diseases of the nervous system

  This study is testing if a new treatment using CT103A cells can help people with certain autoimmune diseases affecting the nervous system feel better.

  Recruiting Early Phase 1 Tongji Hospital · Wuhan, Hubei · NCT04561557

• Optimizing treatment for idiopathic inflammatory myopathies

  This study is testing whether a combination of two treatments or just one can help people with idiopathic inflammatory myopathies feel better when they first start their treatment.

  Recruiting University of Sao Paulo · São Paulo · NCT03092180

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immunophenotypes in inflammatory myopathies and linked lung disease

  A physician-scientist at Vanderbilt is pursuing how immune cells and gene activity differ in Idiopathic Inflammatory Myopathies to find clues for better treatments.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11372793

• Understanding Immune Differences in Muscle Inflammation

  This project aims to understand the unique immune system features in people with idiopathic inflammatory myopathies to find better ways to help them.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11112549

• Exploring how specific genetic elements contribute to autoimmune muscle diseases.

  This study is looking at how certain genetic elements might cause muscle inflammation in people with autoimmune diseases that affect their muscles, and it hopes to find new ways to treat these conditions more effectively and with fewer side effects.

  NIH research University of Washington · Seattle, United States · NIH-11053538

• How high-density lipoprotein function is affected in patients with inflammatory muscle diseases

  This study is looking at how a type of good cholesterol called HDL, which usually helps keep your blood vessels healthy, doesn't work properly in people with idiopathic inflammatory myopathies (IIM), and it aims to find out why this happens and how it might lead to heart problems, so we can discover new ways to help.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10908701

• Investigating immune profiles in inflammatory muscle diseases

  This study is looking at how the immune system affects muscle inflammation in people with idiopathic inflammatory myopathies (IIM) to find new ways to help improve treatment and care for patients like you.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10877796

Related topics

Quick answers

How many Idiopathic Inflammatory Myopathies clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in China (6 trials), United States (4 trials), France (3 trials), Germany (3 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 4, Phase 1/2: 3, Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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