Identifying molecular markers for pulmonary sarcoidosis
Official title: Comprehensive Proteomic Classifier for the Molecular Characterization of Pulmonary Sarcoidosis
Funded at University of Minnesota · NIH-10907457 · Data updated 2026-11-12
This study is looking to find ways to tell if pulmonary sarcoidosis will get worse or stay the same by checking proteins in blood and lung samples, which could help doctors give you the best treatment possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 15, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $690,310 |
| NIH project number | 5R01HL153613-04 |
| Project ID | NIH-10907457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary sarcoidosis, particularly those experiencing symptoms of progressive disease.
✕Less likely to help
Patients with sarcoidosis who are asymptomatic or have already received definitive treatment may not benefit from this research.
What this research studies
This research aims to develop predictive models that can classify pulmonary sarcoidosis into progressive and non-progressive forms. By analyzing proteins in blood and lung samples, the team seeks to identify biomarkers that can help in diagnosing and determining the best treatment strategies for patients. The study involves a multidisciplinary approach, combining expertise in proteomics, immunology, and bioinformatics to understand the disease better. Ultimately, the goal is to improve patient outcomes by providing more targeted and effective treatment options.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and personalized treatment plans for patients with pulmonary sarcoidosis.
How similar studies have gone: Previous research has shown promise in using proteomic approaches to identify biomarkers in other diseases, suggesting potential success for this novel approach in sarcoidosis.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Bhargava, Maneesh — University of Minnesota
- Study coordinator: Bhargava, Maneesh
Related research
Other NIH-funded projects on the same topics.
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Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
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Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
-
Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
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Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
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Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.