Condition

Systemic Lupus Erythematosus clinical trials and research

• 116Clinical trials
• 48NIH research projects
• 1New in 30 days
• 52Countries

Newest Systemic Lupus Erythematosus clinical trials

All recruiting trials (116)

• Effects of anifrolumab on arterial inflammation in SLE patients

  This study tests whether anifrolumab can reduce blood vessel inflammation in people with active systemic lupus erythematosus.

  Recruiting University of Cambridge · Cambridge, Cambridgeshire · NCT07913919

• Home urine testing for people with lupus

  Participants with lupus will try weekly home urine tests in addition to usual care to see if this helps monitor kidney health over a year.

  Recruiting NYU Langone Health · New York, New York · NCT07823478

• CR-402 treatment for refractory autoimmune disease

  This study tests CRT-402, a CD19-targeted CAR-T therapy, in adults with active, treatment-resistant autoimmune diseases like SLE, systemic sclerosis, and inflammatory myopathy to see if it is safe and capable of helping control disease.

  Recruiting Phase 1/2 Myeloid Therapeutics · Nedlands, Western Australia · NCT07778446

• ATG-201 in adults with autoimmune diseases

  This early, open-label study tests ATG-201 in adults with autoimmune diseases to see if it is safe and tolerable, and to get initial clues about how the body handles the drug and its effects.

  Recruiting Phase 1 Antengene Corporation · Bengbu, Anhui and 21 other locations · NCT07732309

• Biomarker tests in adults with lupus to see how kidney disease changes over time

  Researchers will follow adults with lupus to see if blood and urine biomarkers can predict kidney involvement, flares, and treatment responses during routine care.

  Recruiting Oslo University Hospital · Oslo, Oslo · NCT07666711

• Sirolimus added to standard therapy for adults with SLE-associated immune thrombocytopenia

  This trial tests whether adding sirolimus to usual treatment helps adults with SLE-related immune thrombocytopenia see their platelet counts improve.

  Recruiting Phase 2/3 Chinese SLE Treatment And Research Group · Beijing, Beijing Municipality · NCT07657793

• Test of HBM7020 in healthy adults and adults with autoimmune diseases

  This first-in-human study tests whether HBM7020 is safe and how it acts in the body for people with autoimmune diseases like RA, SLE, Sjögren's, and SSc compared with healthy volunteers.

  Recruiting Phase 1 Otsuka Pharmaceutical Development & Commercialization, Inc. · Brisbane, Queensland · NCT07649265

• Reduced vaccine response to GSK Shingrix in people with SLE

  This study tests whether people with systemic lupus erythematosus (SLE) have a different antibody response to the shingles vaccine Shingrix compared with similar people without autoimmune disease.

  Recruiting Seoul National University Hospital · Seoul · NCT07636044

• Subcutaneous anifrolumab in children with systemic lupus erythematosus

  This study tests whether subcutaneous anifrolumab is safe and how it behaves in the body for kids with moderate to severe SLE already on standard care.

  Recruiting at 2 sites Phase 2 AstraZeneca · Nedlands and 38 other locations · NCT07630714

• In vivo CAR-T therapy Arnovie101 for B cell–mediated autoimmune diseases

  This open-label, single-arm study tests Arnovie101, an mRNA-LNP-based in vivo CAR-T therapy, in adults with relapsed or refractory SLE or AIHA to see if it is safe and how the body handles it.

  Recruiting Early Phase 1 Circunited BioPharma (Shenzhen) Co., Ltd. · Beijing, Beijing Municipality · NCT07629596

• ABBV-519 in adults with SLE or RA: safety and how the drug moves through the body after IV and subcutaneous doses

  This early study tests how ABBV-519 behaves in the body and its safety for adults with SLE or RA after single escalating doses.

  Recruiting at 15 sites Phase 1 AbbVie · Anniston, Alabama and 14 other locations · NCT07607964

• Mosunetuzumab for people with systemic lupus erythematosus

  This study tests mosunetuzumab in people with systemic lupus erythematosus, with or without active lupus nephritis.

  Recruiting at 24 sites Phase 2 Hoffmann-La Roche · CABA, Buenos Aires and 23 other locations · NCT07598396

• FT819 in Lupus Nephritis: a targeted cell therapy trial for moderate-to-severe LN

  This trial tests whether FT819, a donor-derived CAR T cell therapy, can help people with difficult-to-treat lupus nephritis who have not responded to other medicines.

  Recruiting at 12 sites Phase 2 Fate Therapeutics · Beverly Hills, California and 11 other locations · NCT07570862

• Anti-CD19/BCMA universal CAR-T cell therapy for refractory autoimmune diseases

  This will try anti-CD19/BCMA universal CAR-T cell therapy in adults with refractory rheumatoid arthritis, dermatomyositis, systemic lupus, or systemic sclerosis to see if it is safe and can control their disease.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07558850

• MTS109 treatment for refractory autoimmune diseases

  This trial tests whether MTS109 (an mRNA-LNP given by subcutaneous injection) is safe and tolerable in adults with moderate to severe autoimmune diseases that have not responded to standard treatments.

  Recruiting Early Phase 1 Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT07526350

• Immun4Cure Cohort of Autoimmune Diseases

  A long-term, 500-person database and biobank is being built to study autoimmune diseases like RA, SLE, and scleroderma, plus healthy adults, using deep profiling and regular follow-ups over five years.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07515638

• E6742 for adults with active systemic lupus erythematosus

  This trial tests whether different doses of E6742 help adults with active systemic lupus erythematosus reduce disease activity while on a low dose of oral steroids by Week 24.

  Recruiting at 46 sites Phase 2 Eisai Inc. · Bengbu, Anhui and 53 other locations · NCT07515014

• TQH3906 in Systemic Lupus Erythematosus (Phase 2)

  This study tests whether TQH3906 capsules are safe and helpful for people with systemic lupus erythematosus.

  Recruiting at 2 sites Phase 2 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Bengbu, Anhui and 34 other locations · NCT07509892

• Weekly subcutaneous anifrolumab added to antimalarial for people with lupus who are immunosuppressant- and biologic-naïve

  This trial tests whether once-weekly 120 mg subcutaneous anifrolumab plus antimalarial (with or without steroids) helps adults with lupus who have not used immunosuppressants or biologics reach remission and come off long-term steroids.

  Recruiting at 50 sites Phase 3 AstraZeneca · Anniston, Alabama and 107 other locations · NCT07430306

• Different doses of BI 3000202 for adults with lupus

  We are testing whether different doses of BI 3000202 can help adults with systemic lupus erythematosus (lupus).

  Recruiting at 87 sites Phase 2 Boehringer Ingelheim · Beverly Hills, California and 138 other locations · NCT07409181

• Phase 3 MIL62 treatment for systemic lupus erythematosus

  This study will test whether MIL62 is more effective and safe than placebo for adults with active systemic lupus erythematosus.

  Recruiting Phase 3 Beijing Mabworks Biotech Co., Ltd. · Beijing · NCT07405970

• CD19 CAR-T (PTOC1) therapy for refractory systemic lupus erythematosus

  This study will try a fast-made CD19 CAR-T cell treatment called PTOC1 in people aged 5 and older whose lupus has not improved with high-dose steroids and multiple immunosuppressive drugs.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Chongqing · NCT07403097

• TREX1 gene changes in adults with lupus who have skin symptoms

  This study will test whether TREX1 gene variants are linked to skin problems in adults with systemic lupus erythematosus.

  Recruiting South Valley University · Qina, South Valley · NCT07397728

• GSK5926371 for B-cell driven autoimmune rheumatic diseases

  This trial will test whether the experimental drug GSK5926371 is safe and well tolerated in adults with B-cell-driven autoimmune rheumatic diseases such as lupus and rheumatoid arthritis.

  Recruiting at 19 sites Phase 1 GlaxoSmithKline · Buenos Aires and 18 other locations · NCT07371468

• MK-1045 for people with lupus or rheumatoid arthritis

  This research tests the experimental medicine MK-1045 to see if it is safe and tolerable in adults with lupus or rheumatoid arthritis.

  Recruiting at 20 sites Phase 1 Merck Sharp & Dohme LLC · Southport, Queensland and 20 other locations · NCT07363590

• Ultra-fast autologous CD19 CAR-T therapy for refractory SLE

  This trial will try ultra-fast autologous CD19 CAR-T cells to see if they can control disease in adults with refractory systemic lupus erythematosus.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Nanjing, Jiangsu · NCT07331467

• Testing a single subcutaneous injection of LBL-047 in healthy adults and people with systemic lupus erythematosus

  This will test whether a single under-the-skin injection of LBL-047 is safe and shows early benefit for healthy adults and adults with mild to moderate systemic lupus erythematosus.

  Recruiting at 11 sites Phase 1 Nanjing Leads Biolabs Co.,Ltd · Bengbu, Anhui and 11 other locations · NCT07323173

• Ultra-fast BCMA/CD70 CAR-T therapy for refractory lupus

  This trial will test ultra-fast BCMA/CD70 CAR-T cell therapy in adults with systemic lupus erythematosus that has not responded to standard treatments.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Nanjing, Jiangsu · NCT07318259

• SHR-2173 for adults with systemic lupus erythematosus

  This trial will try an injectable drug called SHR-2173 to help adults with active systemic lupus erythematosus.

  Recruiting at 2 sites Phase 2 Guangdong Hengrui Pharmaceutical Co., Ltd · Beijing, Beijing Municipality and 1 other locations · NCT07299422

• LY4298445 in healthy adults and people with lupus or rheumatoid arthritis

  This trial will test whether LY4298445 is safe and well tolerated in healthy adults and in people with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA).

  Recruiting at 2 sites Phase 1 Eli Lilly and Company · Brisbane and 9 other locations · NCT07276958

• Ferroptosis in Lupus: Can selenium help?

  This study tests whether iron-dependent cell death (ferroptosis) plays a role in lupus and whether selenium compounds can reduce ferroptosis in people with systemic lupus erythematosus.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT07260942

• Characterization of Autoreactive B Cells in Autoimmune Diseases and Immune Deficiencies

  Researchers are testing to see how autoreactive B cells behave in people with autoimmune diseases or immune deficiencies to better understand how these cells may contribute to disease.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07251179

• Anti-CD19/BCMA U CAR-T cell therapy for relapsed or refractory autoimmune diseases

  This pilot will test whether anti-CD19/BCMA U CAR-T cells can help adults with relapsed or refractory autoimmune diseases such as SLE, systemic sclerosis, Sjögren's syndrome, and rheumatoid arthritis.

  Recruiting Early Phase 1 Changhai Hospital · Shanghai · NCT07246096

• YTS109 cell therapy for relapsed or refractory autoimmune diseases

  This will try a single infusion of YTS109 immune cells to see if they are safe and help adults 18–65 with relapsed or refractory lupus (including lupus nephritis), Sjogren's syndrome, inflammatory myopathy, or ANCA‑associated vasculitis.

  Recruiting Phase 1 China Immunotech (Beijing) Biotechnology Co., Ltd. · Bengbu · NCT07236762

• Ultra-fast autologous CD19 CAR-T therapy for refractory systemic lupus erythematosus

  This trial will try ultra-fast autologous CD19 CAR-T cell therapy in people aged 5 and older with moderate-to-severe SLE that has not responded to high-dose steroids and multiple immunosuppressants.

  Recruiting Phase 1 The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT07233642

• Alnuctamab treatment for refractory SLE

  This trial will test whether the experimental T-cell engager alnuctamab is safe and helps adults 18–60 with moderate-to-severe SLE that has not responded to standard treatments.

  Recruiting Phase 1 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07219563

• Real-world use of anifrolumab for active systemic lupus erythematosus

  This project will see if anifrolumab helps adults with active systemic lupus erythematosus when given in routine clinical care.

  Recruiting University of Pisa · Pisa · NCT07215754

• Surovatamig injections for adults with rheumatoid arthritis or lupus

  This study will try giving subcutaneous surovatamig to adults with rheumatoid arthritis or lupus to see if it is safe and how the body processes it.

  Recruiting at 26 sites Phase 1 AstraZeneca · Birmingham, Alabama and 34 other locations · NCT07201558

• Creating Health online course for people with rheumatological conditions

  This project will test whether an online course about diet and self-care helps adults with rheumatoid arthritis, Sjogren's syndrome, lupus, mixed connective tissue disease, or psoriatic arthritis reduce fatigue and improve quality of life.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07180537

• UB-VV410 for adults with active, treatment-refractory systemic lupus and lupus nephritis

  This trial will test whether UB-VV410 is safe and how it acts in adults with active, treatment-refractory systemic lupus erythematosus, including those with lupus nephritis.

  Recruiting Phase 1 Nanjing IASO Biotechnology Co., Ltd. · Nanjing · NCT07109986

• ONT01 for Lupus Nephritis and Systemic Lupus Erythematosus

  We will test whether ONT01 is safe and helps adults with lupus nephritis or active SLE when added to standard medicines like mycophenolate.

  Recruiting Early Phase 1 Hospital for Special Surgery, New York · New York, New York · NCT07107659

• Grouping people with SLE by antibodies, genes, and biomarkers to better understand causes and guide treatment

  This project will see if dividing people with SLE into subgroups by autoantibodies, genetics, or other biomarkers helps explain and predict their risk of blood vessel disease and organ complications.

  Recruiting Region Stockholm · Stockholm · NCT07102030

• Telitacicept versus cyclophosphamide for lupus-related interstitial lung disease

  This trial will test whether telitacicept works better than cyclophosphamide to treat early interstitial lung disease in adults with lupus.

  Recruiting Phase 4 Tongji Hospital · Wuhan, Hubei · NCT07077486

• Imaging in Inflammatory Heart Diseases linked to autoimmune disorders

  This study tests how well multimodality imaging (CMR, echocardiography, and PET) detects inflammation in people with suspected inflammatory heart or autoimmune rheumatic diseases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07077304

• Anifrolumab Pregnancy Study in women with lupus

  This study looks at pregnancy outcomes in women with moderate to severe SLE who took anifrolumab during pregnancy and compares them to similar women who did not take the drug.

  Recruiting AstraZeneca · Cary, North Carolina · NCT07049653

• Budoprutug infusion for adults with active, seropositive lupus

  This trial will try one IV infusion of budoprutug to see if it is safe and how it affects B cells and symptoms in adults 18–65 with active, seropositive lupus who haven't responded to standard treatments.

  Recruiting at 18 sites Phase 1 Climb Bio, Inc. · Allen, Texas and 17 other locations · NCT07011043

• Long-term outcomes for adults with lupus at Peking University People's Hospital

  This project will follow adults with lupus at Peking University People's Hospital for up to 10 years to see how disease activity, organ involvement, achievement of Lupus Low Disease Activity State (LLDAS), and survival change over time.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT07005479

• Follow-up care for new cases of polyarthritis in children and young adults

  This program will try standardized medical follow-up for children and young adults (≤50) with new-onset JIA, RA, psoriatic/seronegative/undifferentiated arthritis, SLE, or diffuse systemic sclerosis who are treatment-naïve or treated ≤3 months to see if more patients reach disease control or remission.

  Recruiting Université Catholique de Louvain · Brussels · NCT07000916

• Anifrolumab and risk of cancers and serious infections in SLE

  This project will see if adults with moderate-to-severe SLE who start anifrolumab have different rates of cancers and serious infections than similar patients receiving standard care.

  Recruiting at 4 sites AstraZeneca · Copenhagen and 3 other locations · NCT07000110

• Transcutaneous vagus nerve stimulation for muscular pain and fatigue in SLE

  This trial tests whether applying gentle skin stimulation over the neck or ear to activate the vagus nerve can reduce musculoskeletal pain and fatigue in people with systemic lupus erythematosus.

  Recruiting Phase 2 Northwell Health · Manhasset, New York · NCT06987565

• Intravenous ABBV-319 for adults with SLE or Sjögren's disease

  This trial will test whether two IV doses of ABBV-319 given 21 days apart are safe, reach expected blood levels, and might help adults with SLE or Sjögren's disease.

  Recruiting at 9 sites Phase 1 AbbVie · Avon Park, Florida and 10 other locations · NCT06977724

• CAR T-cell therapy for autoimmune diseases

  This study is testing a new CAR T-cell therapy to see if it can help people with tough autoimmune diseases like lupus and systemic sclerosis feel better.

  Recruiting Phase 1 Institute of Hematology & Blood Diseases Hospital, China · Tianjin · NCT06941129

• BCMA/CD70 CAR-T therapy for treating severe lupus in children

  This study is testing a new CAR-T cell therapy to see if it can help children and young adults with severe lupus who haven't responded well to other treatments.

  Recruiting Phase 1 The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT06934447

• Checking HLA antibody results in people with lupus

  This project will test how often people with lupus have false-positive anti-HLA antibody results and try lab methods to rule out those false positives.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06921239

• UCAR T-cell therapy for patients with systemic lupus erythematosus

  This study is testing a new type of CAR T-cell therapy to see if it can help people with tough cases of systemic lupus erythematosus feel better.

  Recruiting Early Phase 1 Zhejiang University · Hangzhou, Zhejiang · NCT06920433

• Testing CPTX2309 in healthy adults

  This study is testing a new drug called CPTX2309 in healthy adults to see if it is safe and how their bodies react to it.

  Recruiting at 2 sites Phase 1 Capstan Therapeutics · Herston, Queensland and 2 other locations · NCT06917742

• Investigating AZD5492 for treating systemic lupus erythematosus and inflammatory myopathies

  This study is testing a new medication called AZD5492 to see if it can safely help adults with systemic lupus erythematosus and inflammatory myopathies feel better.

  Recruiting at 33 sites Phase 1 AstraZeneca · Anniston, Alabama and 37 other locations · NCT06916806

• GNC-038 tetra-specific antibody injection for adults with moderate-to-severe systemic lupus erythematosus

  This study will test whether GNC-038, a tetra-specific antibody injection, is safe and can reduce disease activity in adults with moderate-to-severe systemic lupus erythematosus.

  Recruiting Phase 1 Sichuan Baili Pharmaceutical Co., Ltd. · Shanghai, Shanghai Municipality · NCT06857214

• CorEvitas SLE medication safety and effectiveness registry

  This registry collects health and treatment information from adults with lupus to see how commonly used SLE medicines work and how safe they are.

  Recruiting CorEvitas · Waltham, Massachusetts · NCT06804057

• Evaluating HN2301 for treating difficult cases of systemic lupus erythematosus

  This study is testing if HN2301 injections can help adults with tough cases of lupus who haven't improved with regular treatments.

  Recruiting Phase 1 Shenzhen MagicRNA Biotechnology Co., Ltd · Hefei, Anhui · NCT06801119

• Monitoring pregnancy and infant outcomes after anifrolumab exposure

  This program collects health information to see if exposure to the lupus medicine anifrolumab affects pregnant people or their babies.

  Recruiting AstraZeneca · Södertälje · NCT06795893

• BCMA-CD19 CAR-T therapy for autoimmune diseases

  This study is testing a new CAR-T cell therapy to see if it can help adults with tough autoimmune diseases feel better and improve their health.

  Recruiting Phase 2 Peking University People's Hospital · Beijing, Beijing Municipality · NCT06794008

• Identifying biomarkers for early diagnosis of inflammatory rheumatic diseases

  This study is trying to find specific markers in the body that can help doctors diagnose inflammatory rheumatic diseases like Ankylosing Spondylitis, Rheumatoid Arthritis, and Systemic Lupus Erythematosus earlier and more accurately.

  Recruiting Universidade Nova de Lisboa · Lisbon · NCT06778343

• Cell therapy using UC-MSCs for patients with lupus

  This study is testing if a new treatment using stem cells from umbilical cords can help adults with lupus feel better and improve their kidney health.

  Recruiting Phase 1 LiveKidney.Bio · Charleston, South Carolina · NCT06737380

• Using CAR-T cells to treat moderate to severe lupus

  This study is testing if a new type of CAR-T cell therapy can help people with moderate to severe lupus feel better and manage their symptoms.

  Recruiting Early Phase 1 Zhejiang University · Hangzhou, Zhejiang · NCT06711146

• Zamtocabtagene Autologous CAR-T for Autoimmune Diseases

  This early-phase study tests whether a patient’s own CAR-T cells (zamto-cel) can be safely given after standard therapy to people with lupus or systemic sclerosis.

  Recruiting Phase 1 Miltenyi Biomedicine GmbH · Milwaukee, Wisconsin · NCT06708845

• Using CD19 Universal CAR T Cells to Treat Severe Systemic Lupus Erythematosus

  This study is testing if a new type of CAR T cell treatment can help children with severe lupus who haven't responded to other therapies.

  Recruiting Phase 1 The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT06691152

• Registry to investigate maternal and infant outcomes in users of anifrolumab during pregnancy

  This study is looking to see how using the drug anifrolumab during pregnancy affects mothers and their babies, specifically for those with systemic lupus erythematosus.

  Recruiting AstraZeneca · Wilmington, North Carolina · NCT06659029

• Evaluating the safety and tolerability of HC022 in healthy individuals

  This study is testing a new drug called HC022 in healthy people to see if it's safe and how their bodies handle it before it’s used in patients with lupus.

  Recruiting at 2 sites Phase 1 HC Biopharma Inc. · Beijing and 2 other locations · NCT06657703

• Evaluating Dapirolizumab Pegol for Active Systemic Lupus Erythematosus

  This study is testing if adding a new treatment called dapirolizumab pegol can help people aged 16 and older with active lupus feel better while they are already on standard medications.

  Recruiting at 238 sites Phase 3 UCB Pharma · Avondale, Arizona and 244 other locations · NCT06617325

• Using engineered immune cells to treat difficult autoimmune diseases

  This study is testing if a new type of immune cell treatment can help people with tough autoimmune diseases that haven't responded to other therapies.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06614270

• Investigating outcomes in mothers and infants using Anifrolumab

  This study is testing whether Anifrolumab, a medication for lupus, shows up in breast milk and affects breastfeeding mothers and their infants.

  Recruiting Phase 4 AstraZeneca · Las Vegas, Nevada · NCT06594068

• Investigating the role of platelets in autoimmune diseases

  This study looks at how activated platelets interact with immune cells in people with autoimmune diseases like lupus and scleroderma to see how these interactions might affect their condition.

  Recruiting University Hospital, Strasbourg, France · Strasbourg, France · NCT06593041

• Evaluating the safety and efficacy of Rituximab combined with AB-101 for autoimmune diseases

  This study is testing if combining a new treatment called AB-101 with rituximab can safely help adults with certain autoimmune diseases feel better.

  Recruiting Phase 1 IRIS Research and Development, LLC · Plantation, Florida · NCT06581562

• Testing GSK4527363 in healthy individuals and those with systemic lupus erythematosus

  This study is testing a new drug called GSK4527363 in healthy people and those with systemic lupus erythematosus to see how safe it is and how it works in the body.

  Recruiting at 25 sites Phase 1 GlaxoSmithKline · Scottsdale, Arizona and 27 other locations · NCT06576271

• Testing inebilizumab and subcutaneous blinatumomab in adults with active, treatment‑resistant lupus or refractory rheumatoid arthritis

  This trial tests inebilizumab for adults with active, treatment‑resistant lupus with nephritis and tests subcutaneous blinatumomab for adults with active, treatment‑resistant lupus (with or without nephritis) and for adults with active refractory rheumatoid arthritis.

  Recruiting at 48 sites Phase 2 Amgen · Scottsdale, Arizona and 57 other locations · NCT06570798

• Long-term follow-up of patients with systemic lupus erythematosus at Brest CHRU

  This study follows patients with systemic lupus erythematosus to see how their condition changes over time and to gather information that can help improve treatment and understanding of the disease.

  Recruiting University Hospital, Brest · Brest · NCT06551389

• IMC-002 and IMM0306S for active systemic lupus erythematosus

  This study tests IMC-002 and IMM0306S to see if they help adults with active lupus while they continue their usual medications.

  Recruiting Phase 1/2 ImmuneOnco Biopharmaceuticals (Shanghai) Inc. · Beijing · NCT06535412

• Reversing autoimmunity in lupus using cell therapy

  This study is testing a new cell therapy to see if it can help young people with lupus who haven't responded to other treatments.

  Recruiting Phase 1 Seattle Children's Hospital · Seattle, Washington · NCT06465147

• Investigating Neutrophil Extracellular Traps in Systemic Sclerosis

  This study is trying to understand how certain immune cells called Neutrophil Extracellular Traps might be linked to the symptoms and complications of Systemic Sclerosis in patients.

  Recruiting CHU de Reims · Reims · NCT06462768

• Improving communication and medication adherence in lupus patients

  This study is testing a new program to help doctors and Black patients with lupus communicate better about their medications to see if it improves how well they stick to their treatment plans.

  Recruiting Duke University · Durham, North Carolina · NCT06458075

• Combination treatment for autoimmune disorders using specialized cells and chemotherapy

  This study is testing a new combination of specialized cells and chemotherapy to see if it can help people with autoimmune disorders like systemic sclerosis and lupus feel better.

  Recruiting at 2 sites Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas and 1 other locations · NCT06434363

• CAR-T cell therapy targeting specific markers in autoimmune diseases

  This study is testing a new CAR-T cell therapy to see if it can help people with tough autoimmune diseases like lupus and Sjogren's syndrome feel better.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06428188

• Treatment of active systemic lupus erythematosus with A-319

  This study is testing a new treatment called A-319 to see if it can help people with active lupus by targeting harmful cells in their immune system.

  Recruiting at 2 sites Phase 1 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei and 1 other locations · NCT06400537

• Using telitacicept to prevent flares in lupus patients

  This study is testing if a new medication called telitacicept can help people with lupus stay stable and avoid flare-ups.

  Recruiting RenJi Hospital · Shanghai · NCT06394063

• YTS109 cell injection for autoimmune diseases

  This study is testing if YTS109 cell injections can help people with stubborn autoimmune diseases feel better and improve their health.

  Recruiting China Immunotech (Beijing) Biotechnology Co., Ltd. · Shanghai, Shanghai Municipality · NCT06379646

• Recording brain activity in patients with lupus

  This study tests how brain activity in lupus patients relates to thinking problems by using a special cap to record their brain waves while they do simple tasks.

  Recruiting Northwell Health · Manhasset, New York · NCT06378736

• Investigating the effects of chlordecone exposure on systemic lupus erythematosus in Martinique

  This study is trying to see if exposure to a pesticide called chlordecone affects how systemic lupus erythematosus (SLE) progresses in patients from Martinique.

  Recruiting University Hospital Center of Martinique · Fort-de-France · NCT06365359

• CAR-T cell therapy for severe systemic lupus erythematosus

  This study is testing a new CAR-T cell therapy to see if it can help people with severe lupus who haven't found relief from other treatments.

  Recruiting Phase 1 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan · NCT06349343

• Using CAR-T cells to treat autoimmune diseases

  This study is testing a new treatment using modified T cells to see if it can help people with autoimmune diseases by targeting and removing harmful B cells.

  Recruiting Phase 1/2 Miltenyi Biomedicine GmbH · Erlangen, Bavaria · NCT06347718

• BAFF-targeted CAR-T (LMY-920) for adults with refractory lupus

  This will try autologous BAFF-targeting CAR-T cells (LMY-920) in adults with refractory systemic lupus to see if the treatment is safe and lowers disease activity.

  Recruiting Phase 1 Luminary Therapeutics · Columbus, Ohio · NCT06340750

• Long-term safety evaluation of ianalumab for systemic lupus erythematosus

  This study is testing the long-term safety of a medication called ianalumab in people with systemic lupus erythematosus who have already tried other treatments.

  Recruiting at 129 sites Phase 3 Novartis · Anniston, Alabama and 166 other locations · NCT06133972

• Evaluating CABA-201 for treating active systemic lupus erythematosus

  This study is testing a new cell therapy called CABA-201 to see if it can help people with active lupus and kidney issues feel better and protect their organs.

  Recruiting at 20 sites Phase 1/2 Cabaletta Bio · Orange, California and 22 other locations · NCT06121297

• CD19 CAR-T therapy for active systemic lupus erythematosus

  This study is testing a new type of treatment using CD19 CAR-T cells to see if it can help people with active systemic lupus erythematosus who aren't getting enough relief from current medications.

  Recruiting Phase 1/2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06106906

• Using CD19 Universal CAR-γδT Cells to treat active systemic lupus erythematosus

  This study is testing a new type of immune cell treatment to see if it can help people with severe systemic lupus erythematosus who aren't doing well with current therapies.

  Recruiting Phase 1/2 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06106893

• Assessing how patient feedback affects treatment adjustments for autoimmune diseases

  This study is testing if regular feedback from patients with autoimmune diseases like gout and rheumatoid arthritis can help doctors make better treatment decisions and improve patient care.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT05927688

• Evaluating Immune Cell Receptors in Lupus Patients

  This study is testing how certain immune cell receptors behave in people with lupus to see if they are linked to active or inactive stages of the disease.

  Recruiting University Hospital, Tours · Tours · NCT05859191

• Intravenous anifrolumab for children with moderate to severe systemic lupus erythematosus

  This study will try intravenous anifrolumab in children with moderate to severe SLE to see if it is safe and helps control their disease while they remain on standard treatment.

  Recruiting at 84 sites Phase 3 AstraZeneca · Phoenix, Arizona and 102 other locations · NCT05835310

• Stopping Hydroxychloroquine in Elderly Patients with Lupus

  This study is testing if older adults with stable lupus can safely stop taking hydroxychloroquine without making their condition worse.

  Recruiting at 11 sites Phase 3 NYU Langone Health · Los Angeles, California and 11 other locations · NCT05799378

• Treating systemic lupus erythematosus with a target approach

  This study is testing if a new treatment approach that focuses on closely managing lupus can help patients feel better compared to the usual care they receive.

  Recruiting at 13 sites Heinrich-Heine University, Duesseldorf · Freiburg im Breisgau, Baden-Wurttemberg and 13 other locations · NCT05714930

• Evaluating immune system aging in lupus patients

  This study is testing how aging affects the immune system in people with lupus compared to healthy individuals to better understand their health outcomes.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT05698173

• Evaluating the safety of a herpes zoster vaccine in lupus patients

  This study is testing if a herpes zoster vaccine is safe for people with lupus and if it helps their immune system respond well.

  Recruiting at 2 sites Phase 4 NYU Langone Health · New York, New York and 1 other locations · NCT05559671

• Anifrolumab's effect on blood vessel health in lupus patients

  This study is testing if the drug anifrolumab can help improve blood vessel health and reduce inflammation in people with lupus.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05440422

• Using stem cell transplants to treat severe autoimmune diseases in young patients

  This study is testing if using stem cell transplants along with strong medications can help young people with severe autoimmune diseases like lupus and scleroderma feel better when other treatments haven't worked.

  Recruiting Phase 2 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05029336

• Evaluating treatment outcomes for pregnant women with systemic lupus erythematosus

  This study is testing how different treatments for systemic lupus erythematosus during pregnancy can affect the health of both mothers and their babies.

  Recruiting Phase 1 Qilu Hospital of Shandong University · Jinan, Shandong · NCT04976465

• Developing a way to measure treatment effects in children with rheumatologic conditions

  This study is trying to find a better way to measure how well treatments work for kids with certain rheumatologic conditions like Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, and Fibromyalgia.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT04833465

• Educational tool for melanoma patients with autoimmune diseases

  This study is testing a new educational tool to help melanoma patients with autoimmune diseases understand their treatment options better and see how easy it is for them to use.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04751396

• Registry and biorepository for rheumatic diseases

  This study is collecting samples and health information from adults with rheumatic diseases at Yale clinics to help researchers learn more about these conditions and improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT04402086

• Multidisciplinary consultation for patients with systemic lupus erythematosus

  This study is trying to see how a team of specialists can help people with lupus by closely checking their health and gathering information to improve treatment.

  Recruiting University Hospital, Brest · Brest · NCT04320680

• Using nivolumab to treat patients with autoimmune disorders and advanced cancer

  This study is testing if nivolumab can safely help people with autoimmune disorders who also have advanced cancer by looking at how well it works and what side effects it might cause.

  Recruiting at 40 sites Phase 1 National Cancer Institute (NCI) · Birmingham, Alabama and 51 other locations · NCT03816345

• Registry for pregnant women with autoimmune diseases

  This study is trying to learn more about how autoimmune diseases affect pregnant women and their babies to help improve their health during and after pregnancy.

  Recruiting Duke University · Durham, North Carolina · NCT03276923

• Validation of the Lupus Low Disease Activity State in the Asia Pacific Region

  This study is testing if keeping lupus patients in a low disease activity state can help them avoid serious health problems over time.

  Recruiting at 19 sites Monash University · Adelaide, South Australia and 19 other locations · NCT03138941

• Understanding systemic lupus erythematosus in the Gullah population

  This study is trying to learn more about systemic lupus erythematosus in the Gullah community to better understand how genetics and the environment affect this disease.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT00756769

• Registry for patients with lupus at Duke University

  This study is collecting information and blood samples from people with lupus at Duke University to see how the disease changes over time and improve care for patients.

  Recruiting Duke University · Durham, North Carolina · NCT00512694

• Predicting pregnancy outcomes in women with lupus and antiphospholipid syndrome

  This study is trying to see if certain proteins can help predict pregnancy outcomes for women with lupus and antiphospholipid syndrome.

  Recruiting at 4 sites Hospital for Special Surgery, New York · Chicago, Illinois and 9 other locations · NCT00198068

• Evaluating the natural history of systemic lupus erythematosus

  This study looks at how systemic lupus erythematosus (SLE) changes over time in patients and their families to see what factors might make someone more likely to develop the disease.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001372

NIH-funded research (newest 40 of 48)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immunostimulatory short non-coding RNAs and lupus

  A study in people with lupus looks at tiny RNA pieces that may spark inflammation, to understand if they drive disease activity.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11497703

• Antiviral factors that limit HIV in people with SLE

  Researchers at Howard University are studying how immune factors in people with lupus may help limit HIV infection.

  NIH research Howard University · Washington, United States · NIH-11470887

• Mechanistic clues about lupus from immune disorders

  This grant looks at why certain immune disorders in people with genetic immune problems lead to lupus-like symptoms, by studying patients and mouse models.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11449228

• Subjective thinking challenges in adults with lupus as they age

  This grant aims to understand how lupus-related cognitive problems affect adults, especially older adults, and tests a real-time method to track daily fluctuations in those symptoms.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-11442899

• Mitochondrial targets of antibodies in lupus (SLE)

  A Johns Hopkins-led study will identify which mitochondrial membrane proteins are targeted by autoantibodies in lupus patients to understand how these immune attacks fuel the disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11440181

• Influenza, Hydroxychloroquine, and the Windows of Self-Peptide Presentation in Lupus

  A doctor-researcher is studying how flu infection and the lupus medication hydroxychloroquine change the way the immune system shows self-parts to trigger or prevent lupus flares in kids.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11438703

• Thinking and brain changes in childhood lupus

  This project uses brain scans and cognitive tests to learn why children with lupus sometimes have trouble with thinking and school.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11415453

• Pregnancy, lupus, and heart health in women with lupus

  This study looks at how managing lupus during pregnancy can affect blood pressure and heart health for women with the disease.

  NIH research Emory University · Atlanta, United States · NIH-11415013

• Brain immune cells and cognitive trouble in lupus

  A study in lupus patients and mouse models looks at how brain macrophages may be linked to thinking problems.

  NIH research Northwestern University · Chicago, United States · NIH-11391085

• New targeted pill for systemic lupus to slow flare activity

  A patient-friendly look at a new oral drug that aims to block a cell process involved in lupus flares to help people with the disease feel better.

  NIH research Trethera Corporation · Sherman Oaks, United States · NIH-11387894

• How follicular T cells influence lupus and what this means for you

  Researchers are studying how a type of immune cell called follicular helper T cells affect lupus, with the goal of finding new ways to limit organ damage.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11387106

• Understanding and preventing life-threatening lung bleeding in lupus patients

  A new NIH grant is exploring why some lupus patients develop dangerous lung bleeding and how we might predict and prevent it.

  NIH research University of Florida · Gainesville, United States · NIH-11385326

• Understanding spinal signals in lupus-related chronic pain

  Aims to understand how a protein called YTHDF2 and its pathway in the spinal cord contribute to chronic pain in people with lupus.

  NIH research Northern California Health Services and Research Foundation · Sacramento, United States · NIH-11361372

• Virtual Mind-Body Resiliency for SARDs (AAV and SLE)

  A patient-facing program will test a virtual group-based mind-body approach to help people with ANCA-associated vasculitis and lupus cope with stress and improve well-being.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11357846

• Immune-based blood tests to guide lupus care

  A patient-friendly blood test approach is being developed to spot early lupus flares and guide treatment before damage happens.

  NIH research Progentec Diagnostics, INC. · Oklahoma City, UNITED STATES · NIH-11325429

• Three-part immune engager to help natural killer cells remove lupus-causing B cells

  A new three-part immune molecule aims to help natural killer cells better find and remove the B cells that drive lupus in people with systemic lupus erythematosus.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11318917

• In vivo engineered CD19/CD138 CAR-T cells for lupus (autoimmune disease)

  Aims to create a one-step, in-body CAR-T therapy to help people with systemic lupus erythematosus by targeting B cells and autoantibody production.

  NIH research Mucommune, LLC · Morrisville, UNITED STATES · NIH-11316654

• Better communication and medication support for people with lupus

  This project trains clinicians and uses pharmacy refill records plus patient-reported barriers to help Black people with lupus take their medicines more reliably.

  NIH research Duke University · Durham, United States · NIH-11310777

• How the Pfizer COVID-19 vaccine affects people with lupus or scleroderma

  This project looks at immune responses to the Pfizer (BNT162b2) COVID-19 vaccine in people with lupus or scleroderma to understand why some have weaker protection.

  NIH research Stanford University · Stanford, United States · NIH-11262193

• Oxidized fat byproducts linked to high blood pressure and lupus

  This project looks at whether blocking harmful oxidized fat molecules called isolevuglandins can lower blood pressure and reduce autoimmune activity in people with hypertension and systemic lupus erythematosus.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11212830

• Brain causes of thinking and mood problems in childhood lupus

  This project uses different brain scans and measures to find why children and teens with lupus have trouble with thinking, memory, or mood.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11173802

• Understanding lupus risk across diverse populations to improve early diagnosis

  A team will combine genetic data from many populations to improve how we predict who is at risk for lupus and how early it can be diagnosed.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11160721

• Improving blood tests to better manage lupus disease activity

  This study is working on new blood tests to help people with lupus better understand their disease and catch flare-ups earlier, so they can get treatment sooner and avoid serious health issues.

  NIH research Progentec Diagnostics, INC. · Oklahoma City, UNITED STATES · NIH-11124845

• Understanding cardiovascular health in children and adults with lupus

  This study is looking at how childhood lupus can impact heart health by checking blood pressure at night, and it aims to find better ways to spot and treat heart risks for kids with this condition.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11094482

• New treatment approach for systemic lupus erythematosus using engineered immune cells

  This study is testing a new treatment that helps your immune system better fight against systemic lupus erythematosus (SLE) by targeting the cells that cause problems, with the hope of making your treatment more effective and reducing flare-ups.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11089846

• Investigating the role of specific proteins in Systemic Lupus Erythematosus

  This study is looking at how certain proteins in your body might be affecting your immune system if you have lupus, by checking for changes in these proteins that could make your symptoms worse, and it hopes to find new ways to help manage the disease.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11077839

• Understanding how the immune system mistakenly attacks DNA in lupus

  This study is looking at how a specific enzyme called DNASE1L3 affects the immune system in people with lupus, to better understand why some patients produce antibodies that attack their own DNA and how this can impact their health.

  NIH research New York University School of Medicine · New York, United States · NIH-11061817

• Why lupus can cause brain and mood problems, using clues from frontotemporal dementia

  This work looks at genes and immune signals that might cause brain and mental health problems in adults with lupus.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11052362

• Understanding how the COVID-19 vaccine works in patients with lupus and scleroderma

  This study is looking at how well the COVID-19 vaccine works for people with lupus and scleroderma, two autoimmune diseases, to see how their immune systems respond and to ensure the vaccine is safe for them.

  NIH research Stanford University · Stanford, United States · NIH-11047679

• Exploring a new treatment for systemic lupus erythematosus using bacterial DNA

  This study is looking at a new treatment for lupus that uses tiny pieces of bacterial DNA to help your immune system work better and reduce side effects from current medications.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-10998519

• Understanding early signs of autoimmune diseases like Sjögren's and lupus

  This study is looking at people who have early signs of autoimmune diseases like Sjögren's and lupus to find helpful markers that can lead to quicker diagnoses and better treatments before the diseases fully develop.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-10998323

• Understanding cognitive issues in children with lupus

  This study is looking at how childhood-onset systemic lupus erythematosus (cSLE) affects kids' thinking and learning, using special brain imaging tools to understand what’s happening in their brains, so we can find better ways to help them.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10987200

• Investigating if Epstein-Barr Virus causes Systemic Lupus Erythematosus

  This study is looking at whether the Epstein-Barr virus might be linked to Systemic Lupus Erythematosus by comparing blood samples from military personnel who develop lupus with those who don’t, to see if there are any differences that could help us understand how lupus might start.

  NIH research Cincinnati VA Medical Center Research · Cincinnati, United States · NIH-10951532

• Investigating the role of isolevuglandins in high blood pressure and lupus

  This study is looking at how certain molecules from fat breakdown might play a role in high blood pressure and lupus, and it's testing ways to block these molecules to help improve health for people with these conditions.

  NIH research Veterans Health Administration · Nashville, United States · NIH-10948077

• Improving communication and medication adherence for Black patients with lupus

  This study is all about helping Black patients with lupus feel more comfortable talking to their doctors so they can stick to their medications better, by training healthcare providers in better communication and understanding the specific challenges these patients face.

  NIH research Duke University · Durham, United States · NIH-10934355

• Improving medication adherence in adolescents with lupus using personalized feedback

  This study is looking to help teenagers with lupus take their medicine regularly by creating a digital tool that shows them how their medication works in their body, making it easier for them to understand why it's important to stick to their treatment plan.

  NIH research Duke University · Durham, United States · NIH-10928505

• Improving health outcomes for lupus patients by addressing social factors

  This study is looking at how social factors affect the health of people with lupus, especially among different racial and ethnic groups, and aims to create a helpful tool that combines social support with medical care to improve health outcomes for patients.

  NIH research Polygon Health Analytics LLC · Chalfont, United States · NIH-10921463

• Exploring how older adults with lupus can engage in digital physical activity programs

  This study is looking at how active older adults with lupus are and what might help or hinder them from exercising, so we can create a digital program that makes it easier for them to stay active and healthy.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-10919876

• Understanding how X chromosome inactivation affects autoimmune disease in women

  This study is looking at how the X chromosome might play a role in lupus, a disease that mostly affects women, by checking how certain genes work in immune cells called B cells, to help us understand why more women get this condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10914657

• Understanding the causes of systemic lupus erythematosus through genetic studies across different ancestries

  This study is looking into the genetic reasons behind systemic lupus erythematosus (SLE), a condition that mainly affects young women, to help find better ways to diagnose it early and understand who might be at risk.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10887632

Related topics

Quick answers

How many Systemic Lupus Erythematosus clinical trials are recruiting right now?

116, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 52 countries. The most sites are in China (47 trials), United States (44 trials), France (22 trials), Spain (13 trials), Japan (12 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 35, Phase 2: 12, Phase 1/2: 8, Early Phase 1: 6. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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