Molecular clues behind progressive lung sarcoidosis
Molecular Characterization of Progressive Pulmonary Sarcoidosis
This project looks at proteins and genes in blood and lab granuloma models to find early signs that someone with sarcoidosis will develop worsening lung disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-11173880 on NIH RePORTER |
What this research studies
If you join this research, investigators will enroll people with pulmonary sarcoidosis and collect blood samples and clinical information. They will compare immune cells from patients who later have worsening lung disease to those whose disease stays stable. Laboratory models of granulomas will be used alongside blood tests to measure proteins and gene activity. The goal is to find molecular signatures that could help identify higher-risk patients earlier and point to biological pathways behind disease progression.
Who could benefit from this research
Good fit: Adults with pulmonary sarcoidosis who can provide blood samples and follow-up clinical data are the most suitable candidates.
Not a fit: People without pulmonary sarcoidosis, or those unwilling/unable to provide blood samples or attend follow-up visits, are unlikely to receive direct benefit.
Why it matters
Potential benefit: If successful, this work could help identify patients at higher risk of progressive lung sarcoidosis so they can get closer monitoring and earlier treatment.
How similar studies have performed: Prior pilot data identified promising protein and gene patterns, but applying these signatures to predict progressive pulmonary sarcoidosis is relatively new.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Maier, Lisa a — National Jewish Health
- Study coordinator: Maier, Lisa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.