Molecular markers of progressive pulmonary sarcoidosis
Official title: Molecular Characterization of Progressive Pulmonary Sarcoidosis
Funded at National Jewish Health · NIH-11396447 · Data updated 2026-11-12
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $767,210 |
| NIH project number | 5R01HL162955-04 |
| Project ID | NIH-11396447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sarcoidosis who may be at risk for progressive pulmonary disease and who consent to blood draws and study participation.
✕Less likely to help
Patients with sarcoidosis whose disease is stable or who do not provide samples may not directly benefit.
What this research studies
People with sarcoidosis can progress to serious lung problems, and this project plans to study blood and lab models to identify molecular clues that predict progression. By comparing those whose disease worsens with those whose lung involvement stays stable, researchers hope to find signatures that flag higher risk early. The team will use patient samples and lab models to map pathways involved in granuloma formation and progression. If successful, the work could lead to earlier monitoring and targeted approaches for people at risk.
Why it matters
Potential benefit: If the findings are confirmed, clinicians could identify high-risk patients sooner and tailor follow-up and treatment to prevent respiratory decline.
How similar studies have gone: Pilot data from the team suggested relevant protein and transcriptional pathways, supporting further investigation in a larger cohort.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Maier, Lisa a — National Jewish Health
- Study coordinator: Maier, Lisa a
Related research
Other NIH-funded projects on the same topics.
-
Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
-
Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
-
Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
-
Understanding why sarcoidosis happens and how it affects people using multi-omics
A multi-omics study aims to uncover why sarcoidosis affects people differently and to find biomarkers that predict disease burden.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.