Immune cell patterns in sarcoidosis
Multi-Omic Characterization of Immune Cells in Sarcoidosis
['FUNDING_R21'] · OKLAHOMA MEDICAL RESEARCH FOUNDATION · NIH-11143841
The project uses gene and protein tests on immune cells to find markers that could help diagnose sarcoidosis and predict how it will behave.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA MEDICAL RESEARCH FOUNDATION (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11143841 on ClinicalTrials.gov |
What this research studies
Researchers will collect blood and, when possible, lung or bronchoalveolar lavage samples from people with sarcoidosis to study immune cells. They will apply multiple 'omics' techniques — including genetics, single-cell RNA sequencing, and protein profiling — to capture how immune cells differ between patients. Advanced bioinformatics will combine these data to identify molecular signatures linked to disease severity, organ involvement, and ancestry. The team will compare results to prior genetic findings, with attention to people of African ancestry, to build potential diagnostic or prognostic markers.
Who could benefit from this research
Good fit: Adults with confirmed or suspected sarcoidosis who can provide blood and/or lung samples — including people of African ancestry — are ideal candidates.
Not a fit: People without sarcoidosis or those seeking immediate therapeutic benefit are unlikely to gain direct clinical improvement from participating in this biomarker-focused project.
Why it matters
Potential benefit: If successful, this work could produce blood- or tissue-based markers to improve sarcoidosis diagnosis and predict which patients may develop more severe or organ-specific disease.
How similar studies have performed: Earlier genetic and single-cell studies in sarcoidosis have identified susceptibility genes and immune cell signals, but fully integrated multi-omic biomarkers for diagnosis and prognosis are still largely unproven.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- OKLAHOMA MEDICAL RESEARCH FOUNDATION — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MONTGOMERY, COURTNEY — OKLAHOMA MEDICAL RESEARCH FOUNDATION
- Study coordinator: MONTGOMERY, COURTNEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Besnier-Boeck Disease, Candidate Disease Gene