Understanding immune responses in sarcoidosis
Immunologiska Mekanismer Vid Sarkoidos
This study is trying to understand how the immune system works in people with sarcoidosis to see if it can help create better, personalized treatments for them.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Region Stockholm Government |
| Locations | 1 site (Stockholm, Stockholm County) |
| Trial ID | NCT06576505 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the immunological mechanisms underlying sarcoidosis, an inflammatory disease that can affect various organs, particularly the lungs and lymph nodes. By analyzing peripheral blood, bronchoscopy samples, and gut microbiome data, the study seeks to identify genetic and immune factors that contribute to the variability in disease progression and treatment response among patients. The research will also include healthy controls to better understand the differences in immune responses. The findings could provide insights into personalized treatment approaches for sarcoidosis patients.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals suspected of having sarcoidosis who are Swedish-speaking and able to understand and approve the study protocol.
Not a fit: Patients who do not have a suspicion of sarcoidosis or are not Swedish-speaking may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective, personalized treatment strategies for patients with sarcoidosis.
How similar studies have performed: While the role of the gut microbiome in sarcoidosis is not well established, similar studies in other inflammatory diseases have shown promising results, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Suspicion of sarcoidosis * Swedish speaking * Able to understand and approve of study protocol * No contraindications for planned interventions * For inclusion of healthy controls they need to be healthy and the same criteria as listed above for patients. Exclusion Criteria: * No suspicion of sarcoidosis * Not Swedish-speaking * Not able to understand study protocol * Not approving of study protocol * Contraindications for planned interventions
Where this trial is running
Stockholm, Stockholm County
- Karolinska University Hospital — Stockholm, Stockholm County, Sweden (Recruiting)
Study contacts
- Principal investigator: Susanna M Kullberg, MD — Karolinska University Hospital
- Study coordinator: Susanna M Kullberg, MD
- Email: susanna.kullberg@regionstockholm.se
- Phone: 070-2715639
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.