Understanding immune responses in sarcoidosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the immunological mechanisms underlying sarcoidosis, an inflammatory disease that can affect various organs, particularly the lungs and lymph nodes. By analyzing peripheral blood, bronchoscopy samples, and gut microbiome data, the study seeks to identify genetic and immune factors that contribute to the variability in disease progression and treatment response among patients. The research will also include healthy controls to better understand the differences in immune responses. The findings could provide insights into personalized treatment approaches for sarcoidosis patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Suspicion of sarcoidosis
* Swedish speaking
* Able to understand and approve of study protocol
* No contraindications for planned interventions
* For inclusion of healthy controls they need to be healthy and the same criteria as listed above for patients.

Exclusion Criteria:

* No suspicion of sarcoidosis
* Not Swedish-speaking
* Not able to understand study protocol
* Not approving of study protocol
* Contraindications for planned interventions

Where it's running

• Karolinska University Hospital
  Stockholm, Stockholm County, Sweden Recruiting

Study contacts

• Principal investigator: Susanna M Kullberg, MD — Karolinska University Hospital
• Study coordinator: Susanna M Kullberg, MD
• Email: susanna.kullberg@regionstockholm.se
• Phone: 070-2715639

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Two prednisolone tapering plans for people with stable sarcoidosis

  The team will try two different prednisolone tapering plans to see if people with stable sarcoidosis taking 5–10 mg/day can safely cut their dose by at least half.

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• Immune cells in lung disease and how they could guide immunotherapy

  This project sees if immune cell profiling from blood can explain why people with lung cancer, sarcoidosis, or COPD respond differently to immunotherapy or develop chronic lung inflammation.

  Recruiting Université Catholique de Louvain · Brussels · NCT07384897

• Imaging in Inflammatory Heart Diseases linked to autoimmune disorders

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  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07077304

• Virtual groups to reduce sarcoidosis-related fatigue

  This project tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can help reduce fatigue and improve anxiety and depression in adults with sarcoidosis compared with a monthly virtual support group.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07073963

• Counting and classifying inflammatory cells in uveitis with OCT

  This project will try to use high-resolution OCT scans to count and categorize inflammatory cells and proteins in people with anterior uveitis and related eye inflammation.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT07065747

• Comparing yoga and physiotherapy for sarcoidosis treatment

  This study is testing whether yoga or traditional physiotherapy helps people with sarcoidosis improve their lung function and feel better overall.

  Recruiting Saglik Bilimleri Universitesi · Istanbul, Maltepe · NCT06848608

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.