Understanding Pulmonary Sarcoidosis with Protein Signatures
Official title: Comprehensive Proteomic Classifier for the Molecular Characterization of Pulmonary Sarcoidosis
Funded at Ohio State University · NIH-11293906 · Data updated 2026-11-12
This project aims to find unique protein patterns in people with pulmonary sarcoidosis to help doctors better understand and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 15, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $517,232 |
| NIH project number | 7R01HL153613-05 |
| Project ID | NIH-11293906 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for individuals living with pulmonary sarcoidosis, particularly those whose disease progression is uncertain or challenging to manage.
✕Less likely to help
Patients without pulmonary sarcoidosis or those whose disease is already stable and well-understood may not directly benefit from this specific diagnostic tool development.
What this research studies
Sarcoidosis is a complex immune disease that can be hard to diagnose and treat, especially when it affects the lungs. Currently, treatments often involve general immune suppression with side effects. Our team is looking for specific protein changes in the lungs and blood that could act as markers for sarcoidosis and help predict if the disease will get worse. By identifying these protein "signatures," we hope to develop new tools for more precise diagnosis and personalized treatment strategies. This could lead to better outcomes and fewer side effects for patients.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose pulmonary sarcoidosis more accurately and predict its progression, allowing for more targeted and effective treatments.
How similar studies have gone: While previous work has identified genetic changes related to progressive sarcoidosis, this project focuses on protein changes, which are the direct effectors of cell function, offering a novel approach building on preliminary data.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Bhargava, Maneesh — Ohio State University
- Study coordinator: Bhargava, Maneesh
Related research
Other NIH-funded projects on the same topics.
-
Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
-
Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
-
Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
-
Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.