Understanding Pulmonary Sarcoidosis with Protein Signatures
Comprehensive Proteomic Classifier for the Molecular Characterization of Pulmonary Sarcoidosis
This project aims to find unique protein patterns in people with pulmonary sarcoidosis to help doctors better understand and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11293906 on NIH RePORTER |
What this research studies
Sarcoidosis is a complex immune disease that can be hard to diagnose and treat, especially when it affects the lungs. Currently, treatments often involve general immune suppression with side effects. Our team is looking for specific protein changes in the lungs and blood that could act as markers for sarcoidosis and help predict if the disease will get worse. By identifying these protein "signatures," we hope to develop new tools for more precise diagnosis and personalized treatment strategies. This could lead to better outcomes and fewer side effects for patients.
Who could benefit from this research
Good fit: This research is relevant for individuals living with pulmonary sarcoidosis, particularly those whose disease progression is uncertain or challenging to manage.
Not a fit: Patients without pulmonary sarcoidosis or those whose disease is already stable and well-understood may not directly benefit from this specific diagnostic tool development.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose pulmonary sarcoidosis more accurately and predict its progression, allowing for more targeted and effective treatments.
How similar studies have performed: While previous work has identified genetic changes related to progressive sarcoidosis, this project focuses on protein changes, which are the direct effectors of cell function, offering a novel approach building on preliminary data.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Bhargava, Maneesh — Ohio State University
- Study coordinator: Bhargava, Maneesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.