Condition

Myocarditis clinical trials and research

• 23Clinical trials
• 33NIH research projects
• 9Countries

Newest Myocarditis clinical trials

All recruiting trials (23)

• Multimodal Cardiac MRI to See How the Heart Is Working

  This study tests a comprehensive MRI approach to characterize heart structure and tissue in adults with suspected or confirmed cardiovascular disease.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07617844

• Routine versus provisional distal perfusion catheter placement during mechanical circulatory support

  This study tests whether placing a distal perfusion catheter routinely or only provisionally improves limb outcomes in patients needing femoral artery support for mechanical circulatory support.

  Recruiting Samsung Medical Center · Changwon and 5 other locations · NCT07482865

• T1 mapping to characterize heart tissue in common heart diseases

  This project tests whether T1 mapping MRI scans, including dye-free native T1, can define normal and disease-specific heart tissue values for adults with various heart conditions.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality · NCT07354646

• Using a myocarditis panel to guide treatment in children

  This will test whether using a combined viral genome, bacterial serology, and inflammation panel to guide treatment helps children under 18 with myocarditis who have arrhythmias or reduced heart function.

  Recruiting Azienda Ospedaliero, Universitaria Ospedali Riuniti · Ancona, The Marches · NCT07086144

• Imaging in Inflammatory Heart Diseases linked to autoimmune disorders

  This study tests how well multimodality imaging (CMR, echocardiography, and PET) detects inflammation in people with suspected inflammatory heart or autoimmune rheumatic diseases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07077304

• Assessing genetic testing's role in arrhythmic myocarditis

  This study is testing how genetic testing can help people with myocarditis and heart rhythm problems by finding specific gene changes that might affect their condition.

  Recruiting Scientific Institute San Raffaele · Milan, Italy/Milan · NCT06889662

• Predicting Ventricular Tachycardias in Patients After Myocarditis

  This study is trying to see if the amount of scar tissue in the hearts of people who have recovered from myocarditis can help predict their risk of serious heart problems like sudden cardiac death or fast heartbeats.

  Recruiting at 3 sites Centro Medico Teknon · Rozzano, Milan and 2 other locations · NCT06730607

• Evaluating endomyocardial biopsy and tailored treatments for pediatric inflammatory heart disease

  This study is testing how a heart tissue sample and personalized treatments can help kids with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT06591260

• Using advanced imaging to evaluate heart muscle scarring in various heart conditions

  This study is testing a new imaging method to see how heart scarring changes over time in people with certain heart conditions.

  Recruiting University of Edinburgh · Edinburgh, Scotland · NCT06409585

• Colchicine treatment for chronic inflammatory cardiomyopathy

  This study tests if colchicine can help people with chronic inflammatory cardiomyopathy who have heart issues feel better by reducing inflammation in their hearts.

  Recruiting at 10 sites Phase 3 Niguarda Hospital · Naples, Campania and 9 other locations · NCT06158698

• National surveillance of myocarditis and pericarditis after mRNA COVID-19 vaccination

  This study is trying to see how mRNA COVID-19 vaccines might affect heart health by following patients who develop heart inflammation after getting vaccinated.

  Recruiting Cardiology Research UBC · Vancouver, British Columbia · NCT06103123

• Monitoring patients with Premature Ventricular Contractions using implantable loop recorders

  This study is testing how well implantable loop recorders can help track heart rhythms in people with Premature Ventricular Contractions to better understand their condition over a year.

  Recruiting at 6 sites Kansas City Heart Rhythm Research Foundation · Overland Park, Kansas and 5 other locations · NCT06060548

• Evaluating biomarkers for predicting outcomes in myocarditis patients

  This study is trying to find out if certain biological markers can help predict how well patients with myocarditis will do over time.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06010199

• Prognosis prediction for patients with cardiovascular and cerebrovascular diseases using multi-omics

  This study is trying to find out how different biological factors affect people with heart and brain blood vessel diseases to help doctors predict outcomes and personalize treatments for them.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06001073

• Evaluating the safety of endocardial myocardial biopsy procedures

  This study is testing the safety of a heart tissue biopsy procedure for patients with heart issues like myocarditis and cardiomyopathies to see how well it works and what risks it might have.

  Recruiting Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05718128

• Registry for heart inflammation after COVID-19 vaccination

  This study is trying to collect information about heart inflammation cases, like myocarditis and pericarditis, that might happen after COVID-19 vaccination to better understand how it affects patients.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT05046002

• Registry for patients with acute myocarditis

  This study is tracking the health and recovery of patients with acute myocarditis to see how different factors affect their long-term outcomes.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04844151

• Registry for patients with cardiomyopathy and myocarditis

  This study is trying to gather health information from people with cardiomyopathy or myocarditis to better understand these conditions and their genetics.

  Recruiting Imperial College London · London · NCT04612296

• Evaluating endomyocardial biopsy and tailored treatments for inflammatory heart disease

  This study is trying to see if a heart tissue test and personalized treatments can help people with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.

  Recruiting Scientific Institute San Raffaele · Milan, Milano · NCT04521790

• A quick 10-minute heart scan for cardiac diseases

  This study is testing a quick 10-minute heart scan to see if it can help diagnose heart problems better and faster for many patients without needing special dyes.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04464655

• Improving cardiovascular risk stratification with T1 mapping in the general population

  This project will test whether CMR T1/T2 mapping can detect early heart inflammation or fibrosis and help predict cardiovascular risk in adults without known heart disease, including people after COVID-19 infection or vaccination.

  Recruiting Johann Wolfgang Goethe University Hospital · Frankfurt am Main, Hesse · NCT04444128

• Identifying Risk Factors for Heart Toxicity from Immune Checkpoint Inhibitors

  This study is trying to find out what factors might increase the risk of heart problems in people receiving immune checkpoint inhibitors for cancer treatment.

  Recruiting Groupe Hospitalier Pitie-Salpetriere · Paris · NCT04294771

• Registry and biobank for arrhythmogenic ventricular cardiomyopathy

  This study is trying to gather information and samples from people with arrhythmogenic ventricular cardiomyopathy and their families to better understand the genetic causes of the condition and improve early diagnosis for those at risk.

  Recruiting at 2 sites Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT03049254

NIH-funded research (33)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Rapid bedside molecular imaging of heart inflammation with ultrasound

  A fast, point-of-care ultrasound test using special contrast bubbles may help doctors quickly see active heart inflammation in people with chest pain or suspected ACS.

  NIH research University of Virginia · Charlottesville, United States · NIH-11445354

• Muscle-Related Enzyme TRIM55 and Autoimmune Heart Inflammation in Aicardi-Goutieres Syndrome

  A new research project studies how a muscle-specific enzyme called TRIM55 drives autoimmune heart inflammation in a genetic syndrome.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11444135

• Targeted CXCR3 blockade to treat immunotherapy-related heart inflammation

  A targeted drug approach aims to prevent or lessen heart inflammation caused by immune therapies in cancer patients, using CXCR3-blocking strategies.

  NIH research Stanford University · Stanford, United States · NIH-11415616

• Viral tricks that disrupt heart cell connections in myocarditis

  This grant looks at how a common cold virus (adenovirus) may mess with the heart’s electrical signals and could lead to dangerous arrhythmias in people with myocarditis.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11406095

• Immunologic and Antigenic Drivers of Immune Checkpoint Inhibitor–Associated Heart Inflammation

  A doctor-scientist team is studying why cancer patients treated with immune checkpoint drugs sometimes develop dangerous heart inflammation and what immune targets cause it.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11388127

• Understanding how T cells and heart cells talk in a life-threatening heart inflammation from cancer immunotherapy

  A doctor–scientist will study how immune T cells interact with heart cells in people treated for cancer who develop dangerous inflammation from immune checkpoint inhibitors.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11377701

• CXCR6+ T-cells and ICI-related heart inflammation

  A physician-scientist at UC San Francisco is studying how specific heart-damaging immune cells (CXCR6+ T-cells) contribute to dangerous heart inflammation caused by cancer immunotherapy.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11372385

• Understanding why immunotherapy can affect the heart and how to protect it

  Researchers are studying why certain cancer immunotherapies cause dangerous heart inflammation and how to prevent it, with a focus on patients who receive immune-boosting treatments.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11364611

• T-cell markers for heart inflammation caused by cancer immunotherapy

  This project aims to find T cell and blood markers that explain and help predict dangerous heart inflammation in people treated with cancer immune checkpoint drugs.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11325325

• Why Chagas disease causes heart inflammation and scarring

  An immune-based therapy made from a Trypanosoma cruzi protein plus an immune-stimulating adjuvant, sometimes given with benznidazole, aims to reduce heart inflammation and scarring in people with chronic Chagas disease.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11309559

• Mapping how viruses affect the hearts of babies and young children

  Researchers will map which heart cells and molecules change during viral myocarditis to help babies and young children with heart inflammation.

  NIH research Cornell University · Ithaca, United States · NIH-11306051

• Heart inflammation caused by cancer immunotherapy

  Researchers are learning how immune-checkpoint cancer drugs can trigger dangerous heart inflammation so future patients can be protected.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11248804

• Boosting helpful immune cells in heart inflammation with a long noncoding RNA

  A new approach aims to quickly boost regulatory immune cells using a long noncoding RNA to help people with acute myocarditis (heart inflammation).

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11237967

• Why some cancer immunotherapy drugs cause dangerous heart inflammation

  Seeing if blocking a chemical signal that draws T cells into the heart can prevent dangerous heart inflammation in people receiving immune checkpoint inhibitor cancer drugs.

  NIH research Stanford University · Stanford, United States · NIH-11158831

• Understanding Immune Differences in Viral Heart Inflammation Between Children and Adults

  This project looks at how the body's defense system reacts differently to viral heart inflammation in children compared to adults, hoping to find better ways to help patients.

  NIH research University of Florida · Gainesville, United States · NIH-11141258

• Understanding how viruses cause heart inflammation differently in men and women

  This work explores how viruses like coxsackievirus B3 lead to heart inflammation, called myocarditis, and why it affects men more severely than women.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11126669

• How viruses disrupt connections between heart cells in myocarditis

  This project looks at how adenovirus damages the links between heart cells and causes dangerous heart rhythms in people with viral myocarditis.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11120898

• Investigating how mitochondrial vesicles affect heart inflammation caused by a virus.

  This study is looking at how tiny particles from cells might affect heart damage in myocarditis, a serious heart issue often caused by viruses, and it hopes to find new ways to help patients, especially since men seem to be more affected than women.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11109764

• Understanding heart inflammation caused by cancer immunotherapy

  This study is looking at how certain cancer treatments can sometimes cause heart inflammation called myocarditis, and it's for patients who are receiving these immunotherapy drugs; the researchers want to understand how this happens so they can help improve care for those affected.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11082466

• Understanding how myocarditis contributes to heart rhythm disorders

  This study is looking at how immune cells affect a serious heart condition called arrhythmogenic cardiomyopathy (ACM) that can cause sudden heart problems in young people, and it aims to find new ways to prevent this condition by testing different treatments in mice with a specific genetic change.

  NIH research University of Utah · Salt Lake City, United States · NIH-11069180

• Understanding heart inflammation caused by cancer immunotherapy

  This study is looking at how certain cancer treatments can sometimes cause heart inflammation, and it's using mice to help understand why this happens so that doctors can find better ways to protect patients' hearts while they receive these therapies.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11050243

• Understanding heart inflammation caused by cancer immunotherapy

  This study is looking at how a serious heart problem called immune-related myocarditis affects cancer patients who are getting certain treatments, and it aims to understand the immune responses in their bodies so that doctors can find safer ways to help them continue their cancer care without heart issues.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11048143

• Understanding heart inflammation and fibrosis caused by Chagas disease.

  This study is looking at how a long-term infection with a parasite can cause heart problems in people with Chronic Chagasic Cardiomyopathy, and it aims to find better treatments, including a new type of therapy that helps boost the immune system.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11041072

• Mapping the cellular responses in acute viral myocarditis

  This study is looking at how the heart reacts to viral infections in babies and young kids, aiming to find out which cells are involved in the inflammation and how they work, so we can better understand and treat this condition.

  NIH research Cornell University · Ithaca, United States · NIH-11041064

• Understanding how T-cells cause heart inflammation from cancer treatments

  This study is looking into how certain cancer treatments can sometimes cause heart inflammation, and it aims to understand how specific immune cells might be causing this issue, so we can find better ways to protect the heart for patients undergoing these therapies.

  NIH research Stanford University · Stanford, United States · NIH-11007197

• Investigating how TIGIT helps protect the heart during cancer immunotherapy

  This study is looking at how a protein called TIGIT might help protect the heart from damage caused by cancer treatments known as immune checkpoint inhibitors, which can sometimes lead to heart problems in patients.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10995605

• Enhancing regulatory T cells to improve treatment for myocarditis

  This study is looking at how a specific type of RNA can help boost special immune cells that reduce inflammation and help heal the heart in people with myocarditis, a heart condition often caused by viruses, with the hope of finding better treatments for patients.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10993144

• How a virus affects heart cell connections during myocarditis

  This study is exploring how a common virus affects heart muscle cells and disrupts their connections, which is important for keeping your heart working well, with the goal of finding better ways to treat viral myocarditis, a condition that can lead to heart problems.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-10892641

• Creating a 3D heart model to study COVID-19 related heart damage

  This study is looking at how COVID-19 can harm the heart, especially a condition called myocarditis, by using tiny 3D models of human hearts made from stem cells, and it's for anyone interested in understanding how immune cells might be involved in heart problems caused by the virus.

  NIH research Clemson University · Clemson, United States · NIH-10889266

• Investigating how mitochondrial vesicles affect heart inflammation caused by a virus and differences between sexes

  This study is looking at how tiny particles from cells might affect heart damage in myocarditis, especially in men, to help find new ways to treat this heart condition that can be caused by viruses like coxsackievirus B3.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-10874609

• Understanding how certain immune cells contribute to heart inflammation caused by cancer treatments.

  This study is looking at how certain immune cells can cause heart inflammation in people receiving cancer treatment, with the goal of finding ways to keep patients safer during their therapy.

  NIH research Stanford University · Stanford, United States · NIH-10867164

• Understanding heart inflammation after COVID-19 vaccination

  This study is looking at how some people might be more likely to develop myocarditis, a rare heart condition, after getting a COVID-19 vaccine, and it’s inviting kids and adults aged 5 and up who have experienced this condition to help by sharing their genetic information so we can better understand and protect those a

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10734071

• Exploring how trained immunity can prevent viral infections that cause heart and pancreas issues

  This study is exploring how a special treatment can help boost the immune system to better fight off viral infections, like those caused by Coxsackieviruses, which can lead to heart and pancreas issues, and it's aimed at finding ways to protect people from these infections.

  NIH research University of Nebraska Lincoln · Lincoln, United States · NIH-10515667

Related topics

Quick answers

How many Myocarditis clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Italy (6 trials), China (5 trials), Canada (3 trials), France (3 trials), United Kingdom (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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