Understanding immune cells in sarcoidosis
Official title: Multi-Omic Characterization of Immune Cells in Sarcoidosis
Funded at Oklahoma Medical Research Foundation · NIH-10954075 · Data updated 2026-11-12
This study is looking at how the immune system works in people with sarcoidosis to find helpful clues for diagnosing and tracking the disease, especially focusing on those of African ancestry.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $127,875 |
| NIH project number | 1R21HL175092-01 |
| Project ID | NIH-10954075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with sarcoidosis, especially those of African descent.
✕Less likely to help
Patients with sarcoidosis who do not have a genetic or immune component to their disease may not benefit from this research.
What this research studies
This research investigates the complex immune responses in patients with sarcoidosis, a disease characterized by the formation of granulomas in various organs. By utilizing advanced techniques in genomics and bioinformatics, the team aims to identify genetic and immune markers that could help in diagnosing and predicting the disease's progression. The study will analyze immune cells from patients to uncover the underlying mechanisms of the disease and how they vary among individuals, particularly those of African ancestry. This multi-omic approach combines data from different biological layers to provide a comprehensive view of the disease.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and personalized treatment strategies for patients with sarcoidosis.
How similar studies have gone: Previous research has shown promise in using multi-omic approaches to understand complex diseases, indicating potential success for this innovative method.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Montgomery, Courtney — Oklahoma Medical Research Foundation
- Study coordinator: Montgomery, Courtney
Related research
Other NIH-funded projects on the same topics.
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Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
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Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
-
Understanding how inflammation and scarring develop in pulmonary sarcoidosis
A doctor-scientist is studying why some people with sarcoidosis develop dangerous lung scarring and how to prevent it.
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Peptide-based Diagnostic Test for Sarcoidosis
A new test using peptide-based ELISA is being developed to diagnose sarcoidosis, potentially reducing the need for invasive lung biopsies.
-
Molecular markers of progressive pulmonary sarcoidosis
This grant looks at proteins and genes in people with sarcoidosis to find early signs that the disease will worsen from the lungs.
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Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.