Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 21 and up

Evaluating vitamin D's role in sarcoidosis

Official title: Vitamin D Homeostasis in Sarcoidosis

Run by University of Texas Southwestern Medical Center · NCT03621553 · Data updated 2026-11-12

This study is testing if giving vitamin D to people with sarcoidosis who have low levels of it can help reduce their symptoms compared to those who get a placebo.

Quick facts

PhasePhase 4
Study typeInterventional
Ages21 Years and up
SexAll
Enrollment90 (estimated)
SponsorUniversity of Texas Southwestern Medical Center
Academic / other
Locations1 site (Dallas, Texas)
StatusRecruiting
StartedJuly 1, 2010
Main results expectedDecember 2026
Study endsDecember 30, 2026
Registry record updatedSeptember 3, 2026
Trial IDNCT03621553 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients diagnosed with sarcoidosis who are also vitamin D insufficient.

Probably not a fit

Patients with active infections, other inflammatory diseases, or malignancies may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how vitamin D levels affect the severity of sarcoidosis and the impact of vitamin D supplementation in patients who are deficient. Participants with sarcoidosis and low vitamin D will be divided into two groups: one receiving standard vitamin D supplementation and the other receiving a placebo. Additionally, patients with sufficient vitamin D levels will serve as control subjects. The study aims to clarify the relationship between vitamin D status and sarcoidosis inflammation.

Why it matters

Potential benefit: If successful, this study could lead to improved management of sarcoidosis through vitamin D repletion.

How similar studies have gone: Other studies have suggested a potential link between vitamin D levels and inflammatory conditions, but this specific approach is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Stable medical condition defined as no hospitalization or emergency room visit in the previous 3 months
* No evidence of active pulmonary or systemic infection
* No other active inflammatory disease,
* No active malignancy.
* Normal serum ionized calcium level

Exclusion Criteria:

* Hospitalization or emergency room visit in the previous 3 months
* Evidence of active pulmonary or systemic infection
* Evidence of active other inflammatory disease
* Evidence of active malignancy
* Elevated serum ionized calcium level

Where it's running

  • University of Texas Southwestern Medical Center, and Parkland Health and Hospital System
    Dallas, Texas, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Biofortified eggs to boost vitamin D in healthy adults

    Aiming to see if eating eggs enriched with vitamin D3 or its active form can raise vitamin D levels in healthy adults with low vitamin D.

    Recruiting Cornell University · Ithaca, New York · NCT07859280

  • Vitamin D Level at Frozen Embryo Transfer and Pregnancy Outcomes

    This study looks at whether a woman's vitamin D level on the day of frozen embryo transfer affects her chances of pregnancy and delivering a baby.

    Recruiting at 2 sites Fakih IVF Fertility Center · Abu Dhabi and 1 other locations · NCT07681115

  • Two prednisolone tapering plans for people with stable sarcoidosis

    The team will try two different prednisolone tapering plans to see if people with stable sarcoidosis taking 5–10 mg/day can safely cut their dose by at least half.

    Recruiting Royal Brompton & Harefield NHS Foundation Trust · London · NCT07498842

  • Immune cells in lung disease and how they could guide immunotherapy

    This project sees if immune cell profiling from blood can explain why people with lung cancer, sarcoidosis, or COPD respond differently to immunotherapy or develop chronic lung inflammation.

    Recruiting Université Catholique de Louvain · Brussels · NCT07384897

  • Imaging in Inflammatory Heart Diseases linked to autoimmune disorders

    This study tests how well multimodality imaging (CMR, echocardiography, and PET) detects inflammation in people with suspected inflammatory heart or autoimmune rheumatic diseases.

    Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07077304

  • Virtual groups to reduce sarcoidosis-related fatigue

    This project tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can help reduce fatigue and improve anxiety and depression in adults with sarcoidosis compared with a monthly virtual support group.

    Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07073963

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.