Evaluating vitamin D's role in sarcoidosis
Official title: Vitamin D Homeostasis in Sarcoidosis
Run by University of Texas Southwestern Medical Center · NCT03621553 · Data updated 2026-11-12
This study is testing if giving vitamin D to people with sarcoidosis who have low levels of it can help reduce their symptoms compared to those who get a placebo.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Status | Recruiting |
| Started | July 1, 2010 |
| Main results expected | December 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | September 3, 2026 |
| Trial ID | NCT03621553 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with sarcoidosis who are also vitamin D insufficient.
✕Probably not a fit
Patients with active infections, other inflammatory diseases, or malignancies may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates how vitamin D levels affect the severity of sarcoidosis and the impact of vitamin D supplementation in patients who are deficient. Participants with sarcoidosis and low vitamin D will be divided into two groups: one receiving standard vitamin D supplementation and the other receiving a placebo. Additionally, patients with sufficient vitamin D levels will serve as control subjects. The study aims to clarify the relationship between vitamin D status and sarcoidosis inflammation.
Why it matters
Potential benefit: If successful, this study could lead to improved management of sarcoidosis through vitamin D repletion.
How similar studies have gone: Other studies have suggested a potential link between vitamin D levels and inflammatory conditions, but this specific approach is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Stable medical condition defined as no hospitalization or emergency room visit in the previous 3 months * No evidence of active pulmonary or systemic infection * No other active inflammatory disease, * No active malignancy. * Normal serum ionized calcium level Exclusion Criteria: * Hospitalization or emergency room visit in the previous 3 months * Evidence of active pulmonary or systemic infection * Evidence of active other inflammatory disease * Evidence of active malignancy * Elevated serum ionized calcium level
Where it's running
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University of Texas Southwestern Medical Center, and Parkland Health and Hospital System
Dallas, Texas, United States Recruiting
Study contacts
- Principal investigator: Connie Hsia, MD — University of Texas Southwestern Medical Center
- Study coordinator: Connie Hsia, MD
- Email: Connie.Hsia@utsouthwestern.edu
- Phone: 2146483426
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Biofortified eggs to boost vitamin D in healthy adults
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Vitamin D Level at Frozen Embryo Transfer and Pregnancy Outcomes
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-
Two prednisolone tapering plans for people with stable sarcoidosis
The team will try two different prednisolone tapering plans to see if people with stable sarcoidosis taking 5–10 mg/day can safely cut their dose by at least half.
-
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This project sees if immune cell profiling from blood can explain why people with lung cancer, sarcoidosis, or COPD respond differently to immunotherapy or develop chronic lung inflammation.
-
Imaging in Inflammatory Heart Diseases linked to autoimmune disorders
This study tests how well multimodality imaging (CMR, echocardiography, and PET) detects inflammation in people with suspected inflammatory heart or autoimmune rheumatic diseases.
-
Virtual groups to reduce sarcoidosis-related fatigue
This project tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can help reduce fatigue and improve anxiety and depression in adults with sarcoidosis compared with a monthly virtual support group.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.