Investigating imaging responses to immune suppressant therapy in cardiac sarcoidosis patients
Official title: Advanced multi-parametric 18F-FDG PET and MRI imaging parameters of response to immune suppressant therapy in patients with active cardiac sarcoidosis
Funded at Icahn School of Medicine at Mount Sinai · NIH-10999907 · Data updated 2026-11-12
This study is looking at how well certain imaging tests can show if patients with cardiac sarcoidosis are responding to their immune-suppressing treatments, with the goal of finding better ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $827,356 |
| NIH project number | 1R01HL172363-01A1 |
| Project ID | NIH-10999907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with active cardiac sarcoidosis who are undergoing or considering immune suppressant therapy.
✕Less likely to help
Patients with cardiac sarcoidosis who are not receiving immune suppressant therapy or those with inactive disease may not benefit from this research.
What this research studies
This research focuses on patients with cardiac sarcoidosis, a condition where inflammation affects the heart. It uses advanced imaging techniques, including 18F-FDG PET and MRI, to assess how well patients respond to immune suppressant therapy. By analyzing various imaging parameters, the study aims to establish clear thresholds that indicate treatment effectiveness. This could help optimize therapy strategies and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for patients with cardiac sarcoidosis, potentially improving their heart health and quality of life.
How similar studies have gone: Other research has shown promising results using imaging techniques to assess treatment responses in similar conditions, indicating that this approach has potential for success.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Fayad, Zahi a. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Fayad, Zahi a.
Related research
Other NIH-funded projects on the same topics.
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Advanced imaging to monitor immune-suppressant therapy in active cardiac sarcoidosis
A patient-focused imaging study to see how MRI and PET 18F-FDG can track how well immune-suppressant treatment is working for active cardiac sarcoidosis.
-
Precision PET attenuation correction for heart PET/MR imaging
Aimed at improving PET/MR heart imaging by perfecting how PET signals are corrected for tissue, so patients get accurate results in one combined test instead of separate scans.
-
CXCR3 Blockade as a Targeted Therapy for Cardiac Sarcoidosis
A study to see if blocking CXCR3 can help treat heart involvement in sarcoidosis patients using advanced immune profiling and a mouse model.
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MRI and PET scans to track treatment response in active cardiac sarcoidosis
This project uses PET and MRI scans with advanced imaging measures and AI to monitor how people with active cardiac sarcoidosis respond to immune-suppressing treatments.
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Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
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Predicting Lung Health in Sarcoidosis with Vitamin D Metabolism
Aging individuals with sarcoidosis, especially Black/African American women, may benefit from a clearer plan that uses vitamin D biology to predict and improve lung health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.