Counting and classifying inflammatory cells in uveitis with OCT
Official title: Objective Grading of Intraocular Inflammation in Uveitis Using Optical Coherence Tomography
Run by Oregon Health and Science University · NCT07065747 · Data updated 2026-11-12
This project will try to use high-resolution OCT scans to count and categorize inflammatory cells and proteins in people with anterior uveitis and related eye inflammation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 5 Years to 85 Years |
| Sex | All |
| Enrollment | 125 (estimated) |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Status | Recruiting |
| Started | September 1, 2024 |
| Main results expected | September 2026 |
| Study ends | December 2026 |
| Registry record updated | July 17, 2025 |
| Trial ID | NCT07065747 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with active intraocular inflammation from the listed causes (e.g., HLA-B27 uveitis, JIA-associated uveitis, HSV, Birdshot, Behcet, sarcoidosis), individuals with PVD and floaters, or healthy volunteers without prior uveitis or eye surgery.
✕Probably not a fit
People who cannot give informed consent, cannot maintain steady fixation for OCT imaging, cannot attend required visits, or who are pregnant or breastfeeding are not suitable and would likely not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project uses high-resolution optical coherence tomography (OCT) scans to detect and quantify inflammatory cells and proteins in eyes with anterior uveitis and related conditions. Participants include eyes with active inflammation from causes such as HLA-B27-associated uveitis, JIA, HSV, Birdshot, Behcet, sarcoidosis, a posterior vitreous detachment group with floaters, and healthy control eyes. Imaging from these groups will be compared to develop an unbiased, standardized method for counting and classifying cellular and protein findings on OCT. The study excludes people who cannot give consent, maintain stable fixation for imaging, commit to required visits, or who are pregnant or breastfeeding.
Why it matters
Potential benefit: If successful, this could provide an objective, noninvasive way to monitor eye inflammation and guide treatment decisions more precisely.
How similar studies have gone: Prior research has shown OCT can visualize inflammatory cells and vitreous changes, but standardized, automated counting and classification methods remain exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade. 2. Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD). 3. Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery. Exclusion Criteria: 1. Inability to give informed consent. 2. Inability to maintain stable fixation for OCT imaging. 3. Inability to commit to required visits to complete the study. 4. Pregnancy and breastfeeding.
Where it's running
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Casey Eye Institute - Oregon Health & Science University
Portland, Oregon, United States Recruiting
Study contacts
- Principal investigator: Yan Li, PhD — Oregon Health and Science University
- Study coordinator: Humberto Martinez, COT, MBA
- Email: martinhu@ohsu.edu
- Phone: 503-494-7712
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.