Condition

Systemic Sclerosis clinical trials and research

• 46Clinical trials
• 52NIH research projects
• 42Countries

Newest Systemic Sclerosis clinical trials

All recruiting trials (46)

• Test of HBM7020 in healthy adults and adults with autoimmune diseases

  This first-in-human study tests whether HBM7020 is safe and how it acts in the body for people with autoimmune diseases like RA, SLE, Sjögren's, and SSc compared with healthy volunteers.

  Recruiting Phase 1 Otsuka Pharmaceutical Development & Commercialization, Inc. · Brisbane, Queensland · NCT07649265

• Anti-CD19/BCMA universal CAR-T cell therapy for refractory autoimmune diseases

  This will try anti-CD19/BCMA universal CAR-T cell therapy in adults with refractory rheumatoid arthritis, dermatomyositis, systemic lupus, or systemic sclerosis to see if it is safe and can control their disease.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07558850

• Immun4Cure Cohort of Autoimmune Diseases

  A long-term, 500-person database and biobank is being built to study autoimmune diseases like RA, SLE, and scleroderma, plus healthy adults, using deep profiling and regular follow-ups over five years.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07515638

• Nerandomilast for Systemic Sclerosis in Adults

  This study tests whether nerandomilast tablets can help adults with systemic sclerosis compared to a placebo.

  Recruiting at 67 sites Phase 3 Boehringer Ingelheim · Birmingham, Alabama and 247 other locations · NCT07497087

• AZD0120 CD19/BCMA CAR T-cell therapy for systemic sclerosis, inflammatory myopathies, and difficult-to-treat rheumatoid arthritis

  This trial will try a dual-targeting CD19/BCMA CAR T-cell treatment (AZD0120) in adults with systemic sclerosis, idiopathic inflammatory myopathies, or difficult-to-treat rheumatoid arthritis to see if it is safe and well tolerated.

  Recruiting at 5 sites Phase 1/2 AstraZeneca · Tucson, Arizona and 26 other locations · NCT07295847

• Phase 1 safety test of XmAb657 in healthy adults and people with myositis, scleroderma, or Sjögren's

  This study will test whether subcutaneous injections of XmAb657 are safe and well tolerated in healthy adults and people with autoimmune diseases such as idiopathic inflammatory myopathies, systemic sclerosis, or primary Sjögren's syndrome.

  Recruiting Phase 1 Xencor, Inc. · Melbourne · NCT07284797

• Anti-CD19/BCMA U CAR-T cell therapy for relapsed or refractory autoimmune diseases

  This pilot will test whether anti-CD19/BCMA U CAR-T cells can help adults with relapsed or refractory autoimmune diseases such as SLE, systemic sclerosis, Sjögren's syndrome, and rheumatoid arthritis.

  Recruiting Early Phase 1 Changhai Hospital · Shanghai · NCT07246096

• YTS109 cell therapy for relapsed or treatment‑resistant autoimmune diseases

  This will try a single infusion of YTS109 immune cells in adults 18–65 with relapsed or treatment‑resistant autoimmune diseases such as lupus, Sjogren’s, systemic sclerosis, inflammatory myopathies, or ANCA‑associated vasculitis.

  Recruiting at 2 sites Phase 1 China Immunotech (Beijing) Biotechnology Co., Ltd. · Xuzhou, Jiangsu and 1 other locations · NCT07236801

• Off-the-shelf CAR T-cell treatment (ALLO-329) for adults with lupus, inflammatory myopathy, or systemic sclerosis

  This trial tests ALLO-329, an off-the-shelf CAR T-cell therapy, to see if it is safe and helps adults with active SLE (with or without kidney involvement), idiopathic inflammatory myopathy, or systemic sclerosis.

  Recruiting at 17 sites Phase 1 Allogene Therapeutics · Phoenix, Arizona and 17 other locations · NCT07085104

• Imaging in Inflammatory Heart Diseases linked to autoimmune disorders

  This study tests how well multimodality imaging (CMR, echocardiography, and PET) detects inflammation in people with suspected inflammatory heart or autoimmune rheumatic diseases.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07077304

• Nemolizumab for adults with systemic sclerosis

  This trial will test whether nemolizumab can reduce skin thickness in adults with systemic sclerosis over a 52-week treatment period.

  Recruiting at 3 sites Phase 2 Galderma R&D · Ann Arbor, Michigan and 2 other locations · NCT07047690

• Umbilical cord blood CD19-BCMA CAR T cell treatment for refractory lupus nephritis, systemic sclerosis, and Sjögren's with pulmonary hypertension

  This treatment will try umbilical cord blood–derived CD19‑BCMA CAR T cells in people with refractory lupus nephritis, systemic sclerosis, or primary Sjögren's syndrome with pulmonary hypertension who have not responded to standard therapies.

  Recruiting Phase 1/2 Beijing GoBroad Hospital · Beijing, Beijing Municipality · NCT06947473

• CD19-BCMA CAR T cell therapy for difficult-to-treat autoimmune diseases

  This study is testing a new CAR T cell therapy to see if it can help people with tough autoimmune diseases like lupus nephritis, systemic sclerosis, and Sjogren's syndrome who haven't found relief with regular treatments.

  Recruiting Phase 1/2 Beijing GoBroad Hospital · Beijing, China,Beijing · NCT06947460

• Evaluating CTX112 for treating refractory autoimmune diseases in adults

  This study is testing a new CAR T cell treatment called CTX112 to see if it can help adults with tough autoimmune diseases like lupus and scleroderma feel better.

  Recruiting at 16 sites Phase 1 CRISPR Therapeutics · La Jolla, California and 16 other locations · NCT06925542

• Targeted CAR-T therapy for autoimmune diseases

  This study is testing a new CAR-T cell therapy to see if it can help people with autoimmune diseases like lupus, scleroderma, and multiple sclerosis feel better.

  Recruiting Early Phase 1 Nanjing Bioheng Biotech Co., Ltd. · Lianyungang, Jiangus · NCT06775912

• Using engineered natural killer cells to treat immune-mediated diseases

  This study is testing a new type of cell therapy called NKX019 to see if it can safely help people with immune-related diseases like systemic sclerosis and certain types of myopathies.

  Recruiting at 12 sites Phase 1/2 Nkarta, Inc. · Los Angeles, California and 11 other locations · NCT06733935

• Targeted CAR-T therapy for autoimmune diseases

  This study is testing a new type of CAR-T therapy to see if it can help people with active autoimmune diseases feel better and manage their symptoms.

  Recruiting Early Phase 1 Nanjing Bioheng Biotech Co., Ltd. · Bengbu, Anhui · NCT06548607

• Investigating Neutrophil Extracellular Traps in Systemic Sclerosis

  This study is trying to understand how certain immune cells called Neutrophil Extracellular Traps might be linked to the symptoms and complications of Systemic Sclerosis in patients.

  Recruiting CHU de Reims · Reims · NCT06462768

• Combination treatment for autoimmune disorders using specialized cells and chemotherapy

  This study is testing a new combination of specialized cells and chemotherapy to see if it can help people with autoimmune disorders like systemic sclerosis and lupus feel better.

  Recruiting at 2 sites Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas and 1 other locations · NCT06434363

• CAR-T cell therapy for systemic sclerosis treatment

  This study is testing a new CAR-T cell therapy to see if it can help people with early diffuse systemic sclerosis who haven't found relief with other treatments.

  Recruiting Phase 1 RenJi Hospital · Shanghai · NCT06414135

• YTS109 cell injection for autoimmune diseases

  This study is testing if YTS109 cell injections can help people with stubborn autoimmune diseases feel better and improve their health.

  Recruiting China Immunotech (Beijing) Biotechnology Co., Ltd. · Shanghai, Shanghai Municipality · NCT06379646

• Using CAR-T cells to treat autoimmune diseases

  This study is testing a new treatment using modified T cells to see if it can help people with autoimmune diseases by targeting and removing harmful B cells.

  Recruiting Phase 1/2 Miltenyi Biomedicine GmbH · Erlangen, Bavaria · NCT06347718

• Evaluating a new CAR T cell therapy for systemic sclerosis

  This study is testing a new CAR T cell therapy to see if it can help people with systemic sclerosis feel better and manage their symptoms.

  Recruiting at 10 sites Phase 2/3 Cabaletta Bio · New Haven, Connecticut and 9 other locations · NCT06328777

• Nintedanib plus tocilizumab for systemic sclerosis with interstitial lung disease

  This trial will test whether combining nintedanib and tocilizumab helps adults with systemic sclerosis and interstitial lung disease do better than standard treatments over 56 weeks.

  Recruiting Phase 3 National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland · Warsaw, Masovian Voivodeship · NCT06297096

• Understanding hand function issues in systemic sclerosis

  This study looks at how systemic sclerosis affects hand function in patients to see what causes problems and how to better manage them.

  Recruiting UMC Utrecht · Utrecht · NCT06133244

• Cell injection therapy for systemic sclerosis

  This study is testing a new cell injection therapy to see if it can safely help people with systemic sclerosis feel better and reduce skin thickening.

  Recruiting Phase 1/2 Jiangsu Renocell Biotech Company · Nanjing, Jiangsu · NCT06058091

• Exploring how electrical stimulation affects constipation in systemic sclerosis patients

  This study is testing whether a new electrical stimulation treatment can help people with systemic sclerosis who have constipation feel better by improving how their digestive system works.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05989763

• Using Mycophenolate Mofetil for Systemic Sclerosis with Mild Lung Issues

  This study is testing if a medication called mycophenolate mofetil can help people with systemic sclerosis and mild lung problems feel better over 96 weeks.

  Recruiting Phase 2 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec and 2 other locations · NCT05785065

• Cohort of patients with systemic sclerosis at Brest University Hospital

  This study is collecting health information and samples from adults with systemic sclerosis to see how the disease affects their quality of life, pain, and disability over time.

  Recruiting University Hospital, Brest · Brest · NCT05532865

• Analyzing skin cells and immune response in systemic sclerosis

  This study looks at skin and blood samples from people with systemic sclerosis to see how different skin cells and immune cells interact, which could help us understand the disease better and find new treatments.

  Recruiting University Hospital, Lille · Lille · NCT05273138

• Personalized facial rehabilitation for people with systemic sclerosis

  A personalized facial rehabilitation program is being tested to see if it helps adults with facial involvement from systemic sclerosis.

  Recruiting University Hospital, Strasbourg, France · Strasbourg, Bas-Rhin · NCT05177380

• Clopidogrel to prevent systemic sclerosis development

  This study tests if taking clopidogrel can help prevent systemic sclerosis from developing in people who have early signs of the disease.

  Recruiting at 8 sites Phase 2/3 University Hospital, Bordeaux · Bayonne and 10 other locations · NCT05098704

• Using stem cell transplants to treat severe autoimmune diseases in young patients

  This study is testing if using stem cell transplants along with strong medications can help young people with severe autoimmune diseases like lupus and scleroderma feel better when other treatments haven't worked.

  Recruiting Phase 2 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05029336

• Identifying biomarkers in systemic sclerosis and inflammatory myopathies

  This study is trying to find specific markers in the blood and tissues of people with systemic sclerosis and inflammatory myopathies to better understand their diseases and how they progress over time.

  Recruiting University Hospital, Strasbourg, France · Strasbourg, Bas-Rhin · NCT04917705

• Evaluating Itacitinib for treating adults with systemic sclerosis

  This study is testing if a new medication called itacitinib can help adults with systemic sclerosis feel better and reduce skin thickening.

  Recruiting at 43 sites Phase 2 Assistance Publique - Hôpitaux de Paris · Amiens and 45 other locations · NCT04789850

• Registry and biorepository for rheumatic diseases

  This study is collecting samples and health information from adults with rheumatic diseases at Yale clinics to help researchers learn more about these conditions and improve future treatments.

  Recruiting Yale University · New Haven, Connecticut · NCT04402086

• Using fat-derived cells to heal digital ulcers in scleroderma patients

  This study is testing if injections of fat-derived cells can help heal stubborn finger ulcers in people with scleroderma who haven't found relief from other treatments.

  Recruiting Phase 2 University Hospital, Toulouse · Grenoble and 6 other locations · NCT04356755

• Creating a database for patients with immune-mediated inflammatory diseases

  This study is creating a database and biobank for patients with immune-related diseases to see if new information can help improve treatments and understand their conditions better.

  Recruiting University Hospital, Lille · Lille · NCT04334031

• Cohort of patients with systemic sclerosis

  This study is trying to gather information from patients with systemic sclerosis over five years to better understand how the disease develops and find ways to improve treatment.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT04265144

• Gut microbiome changes over six months in adults with systemic sclerosis

  This project will test whether gut bacteria patterns differ over six months between adults with systemic sclerosis and healthy adults matched by age and sex.

  Recruiting Hôpital Européen Marseille · Marseille · NCT04132206

• Registry of patients with connective tissue diseases and lung issues

  This study is collecting health information from patients with connective tissue diseases to see how often they develop lung problems and to understand their treatment over time.

  Recruiting Medical University Innsbruck · Innsbruck · NCT04095351

• High-dose immunoablative therapy with stem cell transplantation for systemic sclerosis

  This study is testing a high-dose treatment followed by stem cell transplantation to see if it can help people with systemic sclerosis feel better and stay healthier.

  Recruiting at 3 sites Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania and 2 other locations · NCT03630211

• Using sodium thiosulfate injections to treat ectopic calcifications and ossifications

  This study is testing whether sodium thiosulfate injections can help reduce pain and improve life for people with rare conditions that cause unwanted calcium buildup in their bodies.

  Recruiting at 11 sites Phase 2 University Hospital, Limoges · Bordeaux and 10 other locations · NCT03582800

• Collection of samples from patients with rheumatic diseases

  This study is collecting samples from people with rheumatic diseases to help researchers learn more about these conditions and improve treatments in the future.

  Recruiting Meir Medical Center · Kfar Saba · NCT03473912

• Biobank for pulmonary hypertension and related conditions

  This study is collecting blood, urine, and stool samples from people with pulmonary hypertension and related conditions to help researchers learn more about the disease and improve treatment options.

  Recruiting Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana · NCT03269630

• Using stem cells to treat digital ulcers in systemic sclerosis

  This study is testing whether injecting stem cells can help people with systemic sclerosis and painful digital ulcers that don't get better with regular treatments.

  Recruiting Phase 1/2 UMC Utrecht · Utrecht · NCT03211793

NIH-funded research (newest 40 of 52)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how a cell protein (SLC9A1) drives skin and lung scarring in systemic sclerosis

  A five-year NIH grant aims to understand how a specific cell protein called SLC9A1 influences scar-forming cells in systemic sclerosis and related lung disease, with the goal of finding possible therapies.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11446161

• From proteins and genes to new treatments for scar-related lung disease

  A large NIH grant is working to map the proteins in the lungs of people with systemic sclerosis to find new targets for drugs that could slow or stop lung fibrosis.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419892

• Cell-level clues to skin scarring in systemic sclerosis and localized scleroderma

  A study at the University of Pittsburgh is looking at how skin cells and their helpers change at the DNA level in adults and children with systemic sclerosis to find new targets to reduce scarring.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419890

• Clinical-Translational Studies in Skin, Lung, and Blood Vessel Problems in Systemic Sclerosis

  A NIH grant supports coordinated efforts to understand and improve health for people with systemic sclerosis and related conditions by sharing resources, data, and pilot projects at MUSC.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419857

• Role of A20 and DREAM in fat cells and skin scarring in systemic sclerosis

  A research project at the University of Michigan looks at how differences in fat tissue and blood vessels relate to skin scarring in systemic sclerosis, with the aim of finding new ways to treat or prevent fibrosis.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11418100

• Vasculopathy in Systemic Sclerosis and Lung Disease in Adults

  A study in adults with systemic sclerosis will look at how blood vessels in the lungs and body relate to the development of lung disease, with the aim of finding new ways to prevent it.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11415664

• Validating New Outcomes to Support Systemic Sclerosis Calcinosis Trials

  A patient-facing look at a study to test reliable ways to measure changes in painful skin calcium deposits from systemic sclerosis to help run future treatments.

  NIH research Yale University · New Haven, United States · NIH-11402752

• Hormonal signals and skin fibrosis in systemic sclerosis

  Researchers are studying how female hormones may drive skin fibrosis in systemic sclerosis and exploring hormone-targeted treatments that could help people with this condition.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11401360

• Functional markers to guide treatment in systemic sclerosis–related lung disease

  A research grant at USC is studying blood biomarkers that show whether medicines are helping people with systemic sclerosis–related interstitial lung disease.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11400497

• Hypoxia-linked NUDT21 and 3'UTR changes drive fibrosis in systemic sclerosis

  A patient-facing study exploring how a gene called NUDT21 and changes in RNA endings may cause skin and lung fibrosis in systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11391972

• Understanding how the DNASE1L3 DNASE1L3 R206C variant drives systemic sclerosis

  A study to figure out how a DNASE1L3 genetic change might cause systemic sclerosis and what that means for patients.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11384423

• Understanding constipation in systemic sclerosis and how autonomic stimulation may help

  A patient-centered look at a study testing whether stimulating the autonomic nervous system can improve constipation in people with systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11381944

• Modulating cleanup of dying cells in scleroderma

  A short program to understand how clearing dying cells affects organ fibrosis in systemic sclerosis and whether guiding this process could help people with the disease.

  NIH research University of Virginia · Charlottesville, United States · NIH-11372208

• IRF7 links immune signals to skin fibrosis in systemic sclerosis

  Researchers are testing whether a key immune regulator, IRF7, drives the fibrotic changes seen in systemic sclerosis and whether targeting this pathway could reduce scarring.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11325823

• Systemic sclerosis-related lung disease: who’s at risk and what blood markers hint at it

  A dedicated research grant asks how to identify which people with systemic sclerosis will develop interstitial lung disease and which blood biomarkers can signal that risk.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11300699

• Pulmonary hypertension risk in systemic sclerosis linked to a DNASE1L3 genetic variant

  A small study is looking at how a specific genetic change in DNASE1L3 might raise the risk of lung blood-vessel problems in people with systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11289756

• Detecting early right-heart changes and future lung high blood pressure in systemic sclerosis

  This project uses advanced heart ultrasound and machine learning to spot early right-heart changes that may predict pulmonary hypertension in people with systemic sclerosis.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11261524

• New treatments for lung scarring in systemic sclerosis

  This project looks for new drug targets and therapies to help people with systemic sclerosis who have scarring in their lungs.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11193264

• How skin cells and their signals change in systemic sclerosis and localized scleroderma

  This project looks at how skin cells and immune cells behave differently in people with systemic sclerosis and localized scleroderma to find biological targets for better treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11193262

• How immune cells drive lung scarring in systemic sclerosis

  Learning how immune signals cause lung scarring in people with systemic sclerosis-associated interstitial lung disease using patient lung tissue to point to better treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11187010

• Small blood vessel damage and lung scarring in systemic sclerosis

  This project looks at whether tiny blood vessel damage in the lungs and body leads to lung scarring in adults with systemic sclerosis.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11177962

• Constipation in systemic sclerosis: nerve and muscle causes

  This project tests whether problems with gut nerves and pelvic floor muscles explain different types of constipation in people with systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11159431

• Investigating the role of specific proteins in pulmonary hypertension linked to systemic sclerosis.

  This study is looking at how certain proteins might play a role in causing pulmonary hypertension in African American women with systemic sclerosis, with the goal of finding new ways to help treat this serious condition.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11142212

• New medicines for lung scarring in scleroderma

  This project is developing a new medicine to help people with lung scarring caused by scleroderma, a condition called SSc-ILD.

  NIH research Eydis Bio, INC. · Durham, United States · NIH-11136500

• Understanding how immune cells behave in a specific lung disease related to scleroderma

  This study is looking at how certain immune cells behave in people with lung problems caused by scleroderma, to better understand what makes these cells act differently and how that might affect lung health.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11087300

• Investigating how a specific protein affects fibrosis in systemic sclerosis

  This study is looking at how a specific protein called IRF7 affects the immune system and scarring in people with systemic sclerosis, with the goal of finding new ways to treat this condition.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11083751

• Understanding how RUNX1 contributes to skin fibrosis in systemic sclerosis.

  This study is looking at how a protein called RUNX1 affects skin thickening in people with systemic sclerosis, a condition that causes hardening of the skin, to help find new ways to treat it and improve patients' lives.

  NIH research Dartmouth College · Hanover, United States · NIH-11070677

• Understanding and improving treatment for systemic sclerosis vasculopathy

  This study is looking at how systemic sclerosis affects blood vessels, especially in the digestive system, to find better ways to monitor and treat patients like you.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11044090

• Measuring skin changes in systemic sclerosis using a new device.

  This study is looking at a new device called Myoton to help doctors get a clearer picture of skin changes in people with systemic sclerosis, so they can make better treatment decisions for you.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11043346

• Improving arm function for patients with systemic sclerosis using telerehabilitation

  This study is testing whether online therapy can help people with systemic sclerosis improve the use of their arms and hands, making it easier for them to get the help they need without having to travel.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11038025

• Understanding how TGF-b3 affects cell changes in systemic sclerosis

  This study is looking at how a protein called TGF-b3 affects certain cells that can cause skin thickening in systemic sclerosis, with the goal of finding new ways to treat the condition and help patients understand what's happening in their bodies.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11033574

• Detecting heart problems early in patients with systemic sclerosis

  This study is looking for better ways to spot pulmonary arterial hypertension (PAH) early in people with systemic sclerosis (SSc) by using new imaging techniques and smart computer tools, so that doctors can help patients sooner and improve their health.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11015054

• Understanding immune cell interactions in systemic sclerosis

  This study is looking at how immune cells and skin cells work together in people with systemic sclerosis to find out what causes skin thickening, with the hope of creating better, personalized treatments to help improve your health.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-11002666

• How estrogen affects immune cells in systemic sclerosis

  This study is looking at how estrogen affects immune cells in people with systemic sclerosis, hoping to find new ways to treat this autoimmune disease by understanding how estrogen influences inflammation and tissue scarring.

  NIH research Dartmouth College · Hanover, United States · NIH-10953977

• Understanding how certain cells change in systemic sclerosis

  This study is looking at how certain cells change in people with systemic sclerosis, a rare autoimmune disease that can cause lung problems, to find new ways to treat the lung issues that come with it.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10950562

• Investigating lung disease in systemic sclerosis to find new treatments

  This study is looking at how lung problems happen in people with systemic sclerosis, hoping to find new ways to help improve lung health by examining proteins and genes related to the disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10929343

• Investigating skin cell changes in systemic sclerosis and localized scleroderma

  This study is looking at how certain skin cells change in people with systemic sclerosis and localized scleroderma, which cause painful skin thickening, to find out what drives these changes and how we might improve treatments for those affected.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10929336

• Exploring new therapies for systemic sclerosis complications

  This study is looking for new treatments for people with systemic sclerosis by exploring the disease's causes and finding helpful markers, so that patients can eventually benefit from better and more targeted therapies.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10929327

• New treatments for lung disease related to systemic sclerosis

  This study is testing a new treatment for people with systemic sclerosis-related lung disease, aiming to help reduce lung inflammation and scarring by targeting a specific protein, and it has shown promising results in early tests.

  NIH research Eydis Bio, INC. · Durham, United States · NIH-10920991

• Understanding how certain cells contribute to lung disease in systemic sclerosis

  This study is looking at how certain genes help turn cells into myofibroblasts, which are important in lung problems for people with systemic sclerosis, to better understand how to treat this condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10910899

Related topics

Quick answers

How many Systemic Sclerosis clinical trials are recruiting right now?

46, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 42 countries. The most sites are in France (15 trials), United States (12 trials), China (11 trials), Australia (4 trials), Germany (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 8, Phase 2: 7, Phase 1: 6, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →